Is there an association between intravenous immunoglobulin resistance and coronary artery lesion in Kawasaki disease?-Current evidence based on a meta-analysis
Coronary artery lesion (CAL) caused by Kawasaki disease (KD) is a leading cause of acquired heart disease in children. Initial treatment of intravenous immunoglobulin (IVIG) can reduce the incidence of CAL. Although most of the current studies have shown a certain correlation between CAL and IVIG re...
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| description | Coronary artery lesion (CAL) caused by Kawasaki disease (KD) is a leading cause of acquired heart disease in children. Initial treatment of intravenous immunoglobulin (IVIG) can reduce the incidence of CAL. Although most of the current studies have shown a certain correlation between CAL and IVIG resistance, the conclusions are not completely consistent. Thus, we performed this meta-analysis to evaluate the association between IVIG resistance and CAL in KD.
PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, and China National Knowledge Infrastructure through April 21, 2020 were searched to detect relevant studies. Data analysis was performed with STATA 15.1.
A total of 53 relevant studies were eligible to this analysis, including 30312 KD patients, of which 4750 were IVIG resistance and 25562 were responders. There was a significant difference found between IVIG resistance and IVIG response groups in the incidence of CAL (P < 0.001, odds ratio (OR), 3.89; 95% confidence interval (CI) (3.18, 4.75)). The heterogeneity test results showed that the I2 value was 74.8%. The meta-regression analysis showed that the study regions might be the sources of heterogeneity. The subgroup analysis suggested that the incidence of CAL in the IVIG resistance group was still higher than that in the IVIG response group under different regions, IVIG resistance diagnostic criteria, CAL diagnostic criteria, and study types. Meanwhile, the sensitivity analysis did not find any significant impact from every single study.
This is the first meta-analysis to reveal the incidence of CAL was associated with IVIG resistance in KD patients. Further well-designed studies with uniform criteria are needed to evaluate the incidence of CAL in IVIG resistant patients. |
| doi_str_mv | 10.1371/journal.pone.0248812 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_2505324603</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_ef50ed5a8123430bbc66ec88d234476c</doaj_id><sourcerecordid>2505324603</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-df3f8c5e4f00f970a01d026fd075200718abca7648e83068b2944ac760fdace63</originalsourceid><addsrcrecordid>eNptUk1v1DAQjRCIlsI_QGCJC5csjp3YzoUKrfhYUYkLnK2JPdl6SexiJ1v11_BXcdht1SJOtmfePM-beUXxsqKrisvq3S7M0cOwugoeV5TVSlXsUXFatZyVglH--N79pHiW0o7ShishnhYnnEtRt6o9LX5vEpkuMSIBTyClYBxMLnjS4XSN6InzU4Q9-jAn4sZx9mE7hG4enCcRk0sTeLMUW2JCDB7iDYE4YT6GnA4LAfkK15DgpyPWJYSE5-V6jhH9RHDvLC4EXQ5bkuFARpyghCztJtM_L570MCR8cTzPih-fPn5ffykvvn3erD9clKZhYiptz3tlGqx7SvtWUqCVpUz0lsqGUSorBZ2BLFqh4lSojrV1DUYK2lswKPhZ8frAezWEpI-zTZo1eWasFpRnxOaAsAF2-iq6MWvVAZz-Gwhxq7NwZwbU2DcUbQN5I7zmtOuMEGiUsvlZS2Ey1_vjb3M3ojW4DHl4QPow492l3oa9lm3LpaozwdsjQQy_ZkyTHl0yOAzgMW9q6VswKSvJMvTNP9D_q6sPKBNDShH7u2Yqqhe_3VbpxW_66Ldc9uq-kLuiW4PxP0Pa19o</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2505324603</pqid></control><display><type>article</type><title>Is there an association between intravenous immunoglobulin resistance and coronary artery lesion in Kawasaki disease?-Current evidence based on a meta-analysis</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Zheng, Xiaolan ; Li, Jinhui ; Yue, Peng ; Liu, Lei ; Li, Jiawen ; Zhou, Kaiyu ; Hua, Yimin ; Li, Yifei</creator><creatorcontrib>Zheng, Xiaolan ; Li, Jinhui ; Yue, Peng ; Liu, Lei ; Li, Jiawen ; Zhou, Kaiyu ; Hua, Yimin ; Li, Yifei</creatorcontrib><description>Coronary artery lesion (CAL) caused by Kawasaki disease (KD) is a leading cause of acquired heart disease in children. Initial treatment of intravenous immunoglobulin (IVIG) can reduce the incidence of CAL. Although most of the current studies have shown a certain correlation between CAL and IVIG resistance, the conclusions are not completely consistent. Thus, we performed this meta-analysis to evaluate the association between IVIG resistance and CAL in KD.
PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, and China National Knowledge Infrastructure through April 21, 2020 were searched to detect relevant studies. Data analysis was performed with STATA 15.1.
A total of 53 relevant studies were eligible to this analysis, including 30312 KD patients, of which 4750 were IVIG resistance and 25562 were responders. There was a significant difference found between IVIG resistance and IVIG response groups in the incidence of CAL (P < 0.001, odds ratio (OR), 3.89; 95% confidence interval (CI) (3.18, 4.75)). The heterogeneity test results showed that the I2 value was 74.8%. The meta-regression analysis showed that the study regions might be the sources of heterogeneity. The subgroup analysis suggested that the incidence of CAL in the IVIG resistance group was still higher than that in the IVIG response group under different regions, IVIG resistance diagnostic criteria, CAL diagnostic criteria, and study types. Meanwhile, the sensitivity analysis did not find any significant impact from every single study.
This is the first meta-analysis to reveal the incidence of CAL was associated with IVIG resistance in KD patients. Further well-designed studies with uniform criteria are needed to evaluate the incidence of CAL in IVIG resistant patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0248812</identifier><identifier>PMID: 33764989</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Bias ; Biology and Life Sciences ; Birth defects ; Children ; Computer programs ; Congenital defects ; Coronary artery ; Coronary vessels ; Data analysis ; Diseases ; Etiology ; Immunoglobulins ; Intravenous administration ; Kawasaki disease ; Laboratories ; Medical ethics ; Medicine and Health Sciences ; Meta-analysis ; Methodology ; Methods ; Mucocutaneous lymph node syndrome ; Pediatrics ; Physical Sciences ; Research and Analysis Methods ; Science Policy ; Sensitivity analysis ; Software ; Vasculitis ; Veins & arteries ; Womens health</subject><ispartof>PloS one, 2021-03, Vol.16 (3), p.e0248812-e0248812</ispartof><rights>2021 Zheng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Zheng et al 2021 Zheng et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-df3f8c5e4f00f970a01d026fd075200718abca7648e83068b2944ac760fdace63</citedby><cites>FETCH-LOGICAL-c526t-df3f8c5e4f00f970a01d026fd075200718abca7648e83068b2944ac760fdace63</cites><orcidid>0000-0002-3096-4287</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993784/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993784/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33764989$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Xiaolan</creatorcontrib><creatorcontrib>Li, Jinhui</creatorcontrib><creatorcontrib>Yue, Peng</creatorcontrib><creatorcontrib>Liu, Lei</creatorcontrib><creatorcontrib>Li, Jiawen</creatorcontrib><creatorcontrib>Zhou, Kaiyu</creatorcontrib><creatorcontrib>Hua, Yimin</creatorcontrib><creatorcontrib>Li, Yifei</creatorcontrib><title>Is there an association between intravenous immunoglobulin resistance and coronary artery lesion in Kawasaki disease?-Current evidence based on a meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Coronary artery lesion (CAL) caused by Kawasaki disease (KD) is a leading cause of acquired heart disease in children. Initial treatment of intravenous immunoglobulin (IVIG) can reduce the incidence of CAL. Although most of the current studies have shown a certain correlation between CAL and IVIG resistance, the conclusions are not completely consistent. Thus, we performed this meta-analysis to evaluate the association between IVIG resistance and CAL in KD.
PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, and China National Knowledge Infrastructure through April 21, 2020 were searched to detect relevant studies. Data analysis was performed with STATA 15.1.
A total of 53 relevant studies were eligible to this analysis, including 30312 KD patients, of which 4750 were IVIG resistance and 25562 were responders. There was a significant difference found between IVIG resistance and IVIG response groups in the incidence of CAL (P < 0.001, odds ratio (OR), 3.89; 95% confidence interval (CI) (3.18, 4.75)). The heterogeneity test results showed that the I2 value was 74.8%. The meta-regression analysis showed that the study regions might be the sources of heterogeneity. The subgroup analysis suggested that the incidence of CAL in the IVIG resistance group was still higher than that in the IVIG response group under different regions, IVIG resistance diagnostic criteria, CAL diagnostic criteria, and study types. Meanwhile, the sensitivity analysis did not find any significant impact from every single study.
This is the first meta-analysis to reveal the incidence of CAL was associated with IVIG resistance in KD patients. Further well-designed studies with uniform criteria are needed to evaluate the incidence of CAL in IVIG resistant patients.</description><subject>Bias</subject><subject>Biology and Life Sciences</subject><subject>Birth defects</subject><subject>Children</subject><subject>Computer programs</subject><subject>Congenital defects</subject><subject>Coronary artery</subject><subject>Coronary vessels</subject><subject>Data analysis</subject><subject>Diseases</subject><subject>Etiology</subject><subject>Immunoglobulins</subject><subject>Intravenous administration</subject><subject>Kawasaki disease</subject><subject>Laboratories</subject><subject>Medical ethics</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Methodology</subject><subject>Methods</subject><subject>Mucocutaneous lymph node syndrome</subject><subject>Pediatrics</subject><subject>Physical Sciences</subject><subject>Research and Analysis Methods</subject><subject>Science 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there an association between intravenous immunoglobulin resistance and coronary artery lesion in Kawasaki disease?-Current evidence based on a meta-analysis</title><author>Zheng, Xiaolan ; Li, Jinhui ; Yue, Peng ; Liu, Lei ; Li, Jiawen ; Zhou, Kaiyu ; Hua, Yimin ; Li, Yifei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-df3f8c5e4f00f970a01d026fd075200718abca7648e83068b2944ac760fdace63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bias</topic><topic>Biology and Life Sciences</topic><topic>Birth defects</topic><topic>Children</topic><topic>Computer programs</topic><topic>Congenital defects</topic><topic>Coronary artery</topic><topic>Coronary vessels</topic><topic>Data analysis</topic><topic>Diseases</topic><topic>Etiology</topic><topic>Immunoglobulins</topic><topic>Intravenous administration</topic><topic>Kawasaki disease</topic><topic>Laboratories</topic><topic>Medical ethics</topic><topic>Medicine and Health Sciences</topic><topic>Meta-analysis</topic><topic>Methodology</topic><topic>Methods</topic><topic>Mucocutaneous lymph node syndrome</topic><topic>Pediatrics</topic><topic>Physical Sciences</topic><topic>Research and Analysis Methods</topic><topic>Science Policy</topic><topic>Sensitivity analysis</topic><topic>Software</topic><topic>Vasculitis</topic><topic>Veins & arteries</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Xiaolan</creatorcontrib><creatorcontrib>Li, Jinhui</creatorcontrib><creatorcontrib>Yue, Peng</creatorcontrib><creatorcontrib>Liu, Lei</creatorcontrib><creatorcontrib>Li, Jiawen</creatorcontrib><creatorcontrib>Zhou, Kaiyu</creatorcontrib><creatorcontrib>Hua, Yimin</creatorcontrib><creatorcontrib>Li, 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One</addtitle><date>2021-03-25</date><risdate>2021</risdate><volume>16</volume><issue>3</issue><spage>e0248812</spage><epage>e0248812</epage><pages>e0248812-e0248812</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Coronary artery lesion (CAL) caused by Kawasaki disease (KD) is a leading cause of acquired heart disease in children. Initial treatment of intravenous immunoglobulin (IVIG) can reduce the incidence of CAL. Although most of the current studies have shown a certain correlation between CAL and IVIG resistance, the conclusions are not completely consistent. Thus, we performed this meta-analysis to evaluate the association between IVIG resistance and CAL in KD.
PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, and China National Knowledge Infrastructure through April 21, 2020 were searched to detect relevant studies. Data analysis was performed with STATA 15.1.
A total of 53 relevant studies were eligible to this analysis, including 30312 KD patients, of which 4750 were IVIG resistance and 25562 were responders. There was a significant difference found between IVIG resistance and IVIG response groups in the incidence of CAL (P < 0.001, odds ratio (OR), 3.89; 95% confidence interval (CI) (3.18, 4.75)). The heterogeneity test results showed that the I2 value was 74.8%. The meta-regression analysis showed that the study regions might be the sources of heterogeneity. The subgroup analysis suggested that the incidence of CAL in the IVIG resistance group was still higher than that in the IVIG response group under different regions, IVIG resistance diagnostic criteria, CAL diagnostic criteria, and study types. Meanwhile, the sensitivity analysis did not find any significant impact from every single study.
This is the first meta-analysis to reveal the incidence of CAL was associated with IVIG resistance in KD patients. Further well-designed studies with uniform criteria are needed to evaluate the incidence of CAL in IVIG resistant patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33764989</pmid><doi>10.1371/journal.pone.0248812</doi><orcidid>https://orcid.org/0000-0002-3096-4287</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Bias Biology and Life Sciences Birth defects Children Computer programs Congenital defects Coronary artery Coronary vessels Data analysis Diseases Etiology Immunoglobulins Intravenous administration Kawasaki disease Laboratories Medical ethics Medicine and Health Sciences Meta-analysis Methodology Methods Mucocutaneous lymph node syndrome Pediatrics Physical Sciences Research and Analysis Methods Science Policy Sensitivity analysis Software Vasculitis Veins & arteries Womens health |
| title | Is there an association between intravenous immunoglobulin resistance and coronary artery lesion in Kawasaki disease?-Current evidence based on a meta-analysis |
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