Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients
SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus-2), cause of COVID-19 (Coronavirus Disease of 2019), represents a significant risk to people living with pre-existing conditions associated with exacerbated inflammatory responses and consequent dysfunctional immunity. In this paper, we have...
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| creator | Frasca, Daniela Reidy, Lisa Cray, Carolyn Diaz, Alain Romero, Maria Kahl, Kristin Blomberg, Bonnie B |
| description | SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus-2), cause of COVID-19 (Coronavirus Disease of 2019), represents a significant risk to people living with pre-existing conditions associated with exacerbated inflammatory responses and consequent dysfunctional immunity. In this paper, we have evaluated the influence of obesity, a condition associated with chronic systemic inflammation, on the secretion of SARS-CoV-2-specific IgG antibodies in the blood of COVID-19 patients. Our hypothesis is that obesity is associated with reduced amounts of specific IgG antibodies. Results have confirmed our hypothesis and have shown that SARS-CoV-2 IgG antibodies are negatively associated with Body Mass Index (BMI) in COVID-19 obese patients, as expected based on the known influence of obesity on humoral immunity. Antibodies in COVID-19 obese patients are also negatively associated with serum levels of pro-inflammatory and metabolic markers of inflammaging and pulmonary inflammation, such as SAA (serum amyloid A protein), CRP (C-reactive protein), and ferritin, but positively associated with NEFA (nonesterified fatty acids). These results altogether could help to identify an inflammatory signature with strong predictive value for immune dysfunction. Inflammatory markers identified may subsequently be targeted to improve humoral immunity in individuals with obesity and in individuals with other chronic inflammatory conditions. |
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In this paper, we have evaluated the influence of obesity, a condition associated with chronic systemic inflammation, on the secretion of SARS-CoV-2-specific IgG antibodies in the blood of COVID-19 patients. Our hypothesis is that obesity is associated with reduced amounts of specific IgG antibodies. Results have confirmed our hypothesis and have shown that SARS-CoV-2 IgG antibodies are negatively associated with Body Mass Index (BMI) in COVID-19 obese patients, as expected based on the known influence of obesity on humoral immunity. Antibodies in COVID-19 obese patients are also negatively associated with serum levels of pro-inflammatory and metabolic markers of inflammaging and pulmonary inflammation, such as SAA (serum amyloid A protein), CRP (C-reactive protein), and ferritin, but positively associated with NEFA (nonesterified fatty acids). These results altogether could help to identify an inflammatory signature with strong predictive value for immune dysfunction. Inflammatory markers identified may subsequently be targeted to improve humoral immunity in individuals with obesity and in individuals with other chronic inflammatory conditions.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0245424</identifier><identifier>PMID: 33760825</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Antibodies ; Antibodies - blood ; Antibodies - immunology ; Antibodies, Viral - blood ; Antibodies, Viral - immunology ; Arteriosclerosis ; Atherosclerosis ; Biology and Life Sciences ; Biomarkers - blood ; Body Mass Index ; Cancer ; Complications and side effects ; Corona ; Coronavirus Infections - virology ; Coronaviruses ; COVID-19 ; COVID-19 - blood ; COVID-19 - epidemiology ; COVID-19 - immunology ; Data analysis ; Diabetes mellitus ; Editing ; Enzyme-linked immunosorbent assay ; Female ; Funding ; Glycoproteins ; Humans ; Immunity, Humoral - immunology ; Immunoglobulin A - blood ; Immunoglobulin A - immunology ; Immunoglobulin G ; Immunoglobulin G - blood ; Immunoglobulin G - immunology ; Immunoglobulin M ; Immunology ; Inflammatory bowel diseases ; Intestine ; Laboratories ; Male ; Medicine ; Medicine and Health Sciences ; Methodology ; Microbiology ; Middle Aged ; Neutralizing ; Obesity ; Obesity - complications ; Obesity - metabolism ; Obesity - virology ; Pandemics ; Pathology ; Physiological aspects ; Research and Analysis Methods ; Respiratory diseases ; Respiratory tract ; Respiratory tract diseases ; Risk analysis ; Risk factors ; SARS-CoV-2 - immunology ; SARS-CoV-2 - pathogenicity ; Serum levels ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Spike glycoprotein ; Viral antibodies ; Viral diseases ; Viruses</subject><ispartof>PloS one, 2021-03, Vol.16 (3), p.e0245424-e0245424</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Frasca et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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In this paper, we have evaluated the influence of obesity, a condition associated with chronic systemic inflammation, on the secretion of SARS-CoV-2-specific IgG antibodies in the blood of COVID-19 patients. Our hypothesis is that obesity is associated with reduced amounts of specific IgG antibodies. Results have confirmed our hypothesis and have shown that SARS-CoV-2 IgG antibodies are negatively associated with Body Mass Index (BMI) in COVID-19 obese patients, as expected based on the known influence of obesity on humoral immunity. Antibodies in COVID-19 obese patients are also negatively associated with serum levels of pro-inflammatory and metabolic markers of inflammaging and pulmonary inflammation, such as SAA (serum amyloid A protein), CRP (C-reactive protein), and ferritin, but positively associated with NEFA (nonesterified fatty acids). These results altogether could help to identify an inflammatory signature with strong predictive value for immune dysfunction. Inflammatory markers identified may subsequently be targeted to improve humoral immunity in individuals with obesity and in individuals with other chronic inflammatory conditions.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies</subject><subject>Antibodies - blood</subject><subject>Antibodies - immunology</subject><subject>Antibodies, Viral - blood</subject><subject>Antibodies, Viral - immunology</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers - blood</subject><subject>Body Mass Index</subject><subject>Cancer</subject><subject>Complications and side effects</subject><subject>Corona</subject><subject>Coronavirus Infections - virology</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - blood</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 - immunology</subject><subject>Data analysis</subject><subject>Diabetes mellitus</subject><subject>Editing</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Female</subject><subject>Funding</subject><subject>Glycoproteins</subject><subject>Humans</subject><subject>Immunity, Humoral - 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In this paper, we have evaluated the influence of obesity, a condition associated with chronic systemic inflammation, on the secretion of SARS-CoV-2-specific IgG antibodies in the blood of COVID-19 patients. Our hypothesis is that obesity is associated with reduced amounts of specific IgG antibodies. Results have confirmed our hypothesis and have shown that SARS-CoV-2 IgG antibodies are negatively associated with Body Mass Index (BMI) in COVID-19 obese patients, as expected based on the known influence of obesity on humoral immunity. Antibodies in COVID-19 obese patients are also negatively associated with serum levels of pro-inflammatory and metabolic markers of inflammaging and pulmonary inflammation, such as SAA (serum amyloid A protein), CRP (C-reactive protein), and ferritin, but positively associated with NEFA (nonesterified fatty acids). These results altogether could help to identify an inflammatory signature with strong predictive value for immune dysfunction. Inflammatory markers identified may subsequently be targeted to improve humoral immunity in individuals with obesity and in individuals with other chronic inflammatory conditions.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33760825</pmid><doi>10.1371/journal.pone.0245424</doi><tpages>e0245424</tpages><orcidid>https://orcid.org/0000-0002-9816-6679</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Open Access: PubMed Central; MEDLINE; Public Library of Science; Directory of Open Access Journals; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Adult Aged Antibodies Antibodies - blood Antibodies - immunology Antibodies, Viral - blood Antibodies, Viral - immunology Arteriosclerosis Atherosclerosis Biology and Life Sciences Biomarkers - blood Body Mass Index Cancer Complications and side effects Corona Coronavirus Infections - virology Coronaviruses COVID-19 COVID-19 - blood COVID-19 - epidemiology COVID-19 - immunology Data analysis Diabetes mellitus Editing Enzyme-linked immunosorbent assay Female Funding Glycoproteins Humans Immunity, Humoral - immunology Immunoglobulin A - blood Immunoglobulin A - immunology Immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulin M Immunology Inflammatory bowel diseases Intestine Laboratories Male Medicine Medicine and Health Sciences Methodology Microbiology Middle Aged Neutralizing Obesity Obesity - complications Obesity - metabolism Obesity - virology Pandemics Pathology Physiological aspects Research and Analysis Methods Respiratory diseases Respiratory tract Respiratory tract diseases Risk analysis Risk factors SARS-CoV-2 - immunology SARS-CoV-2 - pathogenicity Serum levels Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein Viral antibodies Viral diseases Viruses |
| title | Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients |
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