Etiological and epidemiological characteristics of severe acute respiratory infection caused by multiple viruses and Mycoplasma pneumoniae in adult patients in Jinshan, Shanghai: A pilot hospital-based surveillance study
Severe acute respiratory infection (SARI) results in a tremendous disease burden worldwide. Available research on active surveillance among hospitalized adult patients suffering from SARI in China is limited. This pilot study aimed to identify associated etiologies and describe the demographic, epid...
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| Veröffentlicht in: | PloS one 2021-03, Vol.16 (3), p.e0248750-e0248750 |
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| creator | Li, Jian Song, Can-Lei Wang, Tang Ye, Yu-Long Du, Jian-Ru Li, Shu-Hua Zhu, Jian-Min |
| description | Severe acute respiratory infection (SARI) results in a tremendous disease burden worldwide. Available research on active surveillance among hospitalized adult patients suffering from SARI in China is limited. This pilot study aimed to identify associated etiologies and describe the demographic, epidemiological and clinical profiles of hospitalized SARI patients aged over 16 years in Jinshan, Shanghai.
Active surveillance was conducted at 1 sentinel hospital in Jinshan district, Shanghai, from April 2017 to March 2018. Hospitalized SARI patients aged over 16 years old were enrolled, and nasopharyngeal swabs were collected within 24 hours of admission and tested for multiple respiratory viruses (including 18 common viruses) and Mycoplasma pneumoniae with real-time polymerase chain reaction. Demographic, epidemiological and clinical information was obtained from case report forms.
In total, 397 SARI patients were enrolled; the median age was 68 years, and 194 (48.9%) patients were male. A total of 278 (70.0%) patients had at least one underlying chronic medical condition. The most frequent symptoms were cough (99.2%) and sputum production (88.4%). The median duration of hospitalization was 10 days. A total of 250 infection patients (63.0%) were positive for at least one pathogen, of whom 198 (49.9%) were positive for a single pathogen and 52 (13.1%) were positive for multiple pathogens. The pathogens identified most frequently were M. pneumoniae (23.9%, 95/397), followed by adenovirus (AdV) (11.6%, 46/397), influenza virus A/H3N2 (Flu A/H3N2) (11.1%, 44/397), human rhinovirus (HRhV) (8.1%, 32/397), influenza virus B/Yamagata (Flu B/Yamagata) (6.3%, 25/397), pandemic influenza virus A/H1N1 (Flu A/pH1N1) (4.0%, 16/397), parainfluenza virus (PIV) type 1 (2.0%, 8/397), human coronavirus (HCoV) type NL63 (2.0%, 8/397), HCoV 229E (1.5%, 6/397), HCoV HKU1 (1.5%, 6/397), PIV 3 (1.5%, 6/397), human metapneumovirus (HMPV) (1.5%, 6/397), PIV 4 (1.3%, 5/397), HCoV OC43 (1.0%, 4/397), influenza virus B/Victoria (Flu B/Victoria) (0.5%, 2/397), respiratory syncytial virus (RSV) type B (0.5%, 2/397), and human bocavirus (HBoV) (0.3%, 1/397). The seasonality of pathogen-confirmed SARI patients had a bimodal distribution, with the first peak in the summer and the second peak in the winter. Statistically significant differences were observed with respect to the rates of dyspnea, radiographically diagnosed pneumonia and the presence of at least one comorbidity in patients who we |
| doi_str_mv | 10.1371/journal.pone.0248750 |
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Active surveillance was conducted at 1 sentinel hospital in Jinshan district, Shanghai, from April 2017 to March 2018. Hospitalized SARI patients aged over 16 years old were enrolled, and nasopharyngeal swabs were collected within 24 hours of admission and tested for multiple respiratory viruses (including 18 common viruses) and Mycoplasma pneumoniae with real-time polymerase chain reaction. Demographic, epidemiological and clinical information was obtained from case report forms.
In total, 397 SARI patients were enrolled; the median age was 68 years, and 194 (48.9%) patients were male. A total of 278 (70.0%) patients had at least one underlying chronic medical condition. The most frequent symptoms were cough (99.2%) and sputum production (88.4%). The median duration of hospitalization was 10 days. A total of 250 infection patients (63.0%) were positive for at least one pathogen, of whom 198 (49.9%) were positive for a single pathogen and 52 (13.1%) were positive for multiple pathogens. The pathogens identified most frequently were M. pneumoniae (23.9%, 95/397), followed by adenovirus (AdV) (11.6%, 46/397), influenza virus A/H3N2 (Flu A/H3N2) (11.1%, 44/397), human rhinovirus (HRhV) (8.1%, 32/397), influenza virus B/Yamagata (Flu B/Yamagata) (6.3%, 25/397), pandemic influenza virus A/H1N1 (Flu A/pH1N1) (4.0%, 16/397), parainfluenza virus (PIV) type 1 (2.0%, 8/397), human coronavirus (HCoV) type NL63 (2.0%, 8/397), HCoV 229E (1.5%, 6/397), HCoV HKU1 (1.5%, 6/397), PIV 3 (1.5%, 6/397), human metapneumovirus (HMPV) (1.5%, 6/397), PIV 4 (1.3%, 5/397), HCoV OC43 (1.0%, 4/397), influenza virus B/Victoria (Flu B/Victoria) (0.5%, 2/397), respiratory syncytial virus (RSV) type B (0.5%, 2/397), and human bocavirus (HBoV) (0.3%, 1/397). The seasonality of pathogen-confirmed SARI patients had a bimodal distribution, with the first peak in the summer and the second peak in the winter. Statistically significant differences were observed with respect to the rates of dyspnea, radiographically diagnosed pneumonia and the presence of at least one comorbidity in patients who were infected with only M. pneumoniae, AdV, HRhV, Flu A/H3N2, Flu A /pH1N1 or Flu B/Yamagata. The differences in the positivity rates of the above 6 pathogens among the different age groups were nonsignificant.
M. pneumoniae, AdV and Flu A/H3N2 were the main pathogens detected in hospitalized SARI patients aged over 16 years old in Jinshan district, Shanghai. Our findings highlight the importance of sustained multipathogen surveillance among SARI patients in sentinel hospitals, which can provide useful information on SARI etiologies, epidemiology, and clinical characteristics.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0248750</identifier><identifier>PMID: 33750952</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Adults ; Age ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents - therapeutic use ; Bacterial infections ; Biology and Life Sciences ; Children ; China ; Coronaviruses ; Cough ; Cough - etiology ; Data collection ; Demographic aspects ; Disease prevention ; Distribution ; DNA Viruses - isolation & purification ; Epidemics ; Epidemiology ; Etiology ; Female ; Fever ; Genetic aspects ; Glucocorticoids - therapeutic use ; Health aspects ; Hospitalization ; Hospitals ; Humans ; Infants ; Infections ; Infectious diseases ; Influenza ; Male ; Medicine and Health Sciences ; Microbiology ; Middle Aged ; Mycoplasma pneumoniae ; Mycoplasma pneumoniae - isolation & purification ; Nasopharynx - microbiology ; Nasopharynx - virology ; Pathogens ; Pilot Projects ; Pneumonia ; Prevention ; Prognosis ; Respiratory tract infection ; Respiratory Tract Infections - diagnosis ; Respiratory Tract Infections - drug therapy ; Respiratory Tract Infections - microbiology ; Respiratory Tract Infections - virology ; Risk factors ; RNA Viruses - isolation & purification ; Severe acute respiratory syndrome ; Surveillance ; Viral infections ; Viruses ; Watchful waiting (Medical care) ; Young Adult</subject><ispartof>PloS one, 2021-03, Vol.16 (3), p.e0248750-e0248750</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Li et al 2021 Li et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-af57d0aecc849103fafea0b82726f050042a443b17fde00f7ef361155374cbfe3</citedby><cites>FETCH-LOGICAL-c758t-af57d0aecc849103fafea0b82726f050042a443b17fde00f7ef361155374cbfe3</cites><orcidid>0000-0003-0901-6458</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984646/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984646/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33750952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lin, Baochuan</contributor><creatorcontrib>Li, Jian</creatorcontrib><creatorcontrib>Song, Can-Lei</creatorcontrib><creatorcontrib>Wang, Tang</creatorcontrib><creatorcontrib>Ye, Yu-Long</creatorcontrib><creatorcontrib>Du, Jian-Ru</creatorcontrib><creatorcontrib>Li, Shu-Hua</creatorcontrib><creatorcontrib>Zhu, Jian-Min</creatorcontrib><title>Etiological and epidemiological characteristics of severe acute respiratory infection caused by multiple viruses and Mycoplasma pneumoniae in adult patients in Jinshan, Shanghai: A pilot hospital-based surveillance study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Severe acute respiratory infection (SARI) results in a tremendous disease burden worldwide. Available research on active surveillance among hospitalized adult patients suffering from SARI in China is limited. This pilot study aimed to identify associated etiologies and describe the demographic, epidemiological and clinical profiles of hospitalized SARI patients aged over 16 years in Jinshan, Shanghai.
Active surveillance was conducted at 1 sentinel hospital in Jinshan district, Shanghai, from April 2017 to March 2018. Hospitalized SARI patients aged over 16 years old were enrolled, and nasopharyngeal swabs were collected within 24 hours of admission and tested for multiple respiratory viruses (including 18 common viruses) and Mycoplasma pneumoniae with real-time polymerase chain reaction. Demographic, epidemiological and clinical information was obtained from case report forms.
In total, 397 SARI patients were enrolled; the median age was 68 years, and 194 (48.9%) patients were male. A total of 278 (70.0%) patients had at least one underlying chronic medical condition. The most frequent symptoms were cough (99.2%) and sputum production (88.4%). The median duration of hospitalization was 10 days. A total of 250 infection patients (63.0%) were positive for at least one pathogen, of whom 198 (49.9%) were positive for a single pathogen and 52 (13.1%) were positive for multiple pathogens. The pathogens identified most frequently were M. pneumoniae (23.9%, 95/397), followed by adenovirus (AdV) (11.6%, 46/397), influenza virus A/H3N2 (Flu A/H3N2) (11.1%, 44/397), human rhinovirus (HRhV) (8.1%, 32/397), influenza virus B/Yamagata (Flu B/Yamagata) (6.3%, 25/397), pandemic influenza virus A/H1N1 (Flu A/pH1N1) (4.0%, 16/397), parainfluenza virus (PIV) type 1 (2.0%, 8/397), human coronavirus (HCoV) type NL63 (2.0%, 8/397), HCoV 229E (1.5%, 6/397), HCoV HKU1 (1.5%, 6/397), PIV 3 (1.5%, 6/397), human metapneumovirus (HMPV) (1.5%, 6/397), PIV 4 (1.3%, 5/397), HCoV OC43 (1.0%, 4/397), influenza virus B/Victoria (Flu B/Victoria) (0.5%, 2/397), respiratory syncytial virus (RSV) type B (0.5%, 2/397), and human bocavirus (HBoV) (0.3%, 1/397). The seasonality of pathogen-confirmed SARI patients had a bimodal distribution, with the first peak in the summer and the second peak in the winter. Statistically significant differences were observed with respect to the rates of dyspnea, radiographically diagnosed pneumonia and the presence of at least one comorbidity in patients who were infected with only M. pneumoniae, AdV, HRhV, Flu A/H3N2, Flu A /pH1N1 or Flu B/Yamagata. The differences in the positivity rates of the above 6 pathogens among the different age groups were nonsignificant.
M. pneumoniae, AdV and Flu A/H3N2 were the main pathogens detected in hospitalized SARI patients aged over 16 years old in Jinshan district, Shanghai. Our findings highlight the importance of sustained multipathogen surveillance among SARI patients in sentinel hospitals, which can provide useful information on SARI etiologies, epidemiology, and clinical characteristics.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bacterial infections</subject><subject>Biology and Life Sciences</subject><subject>Children</subject><subject>China</subject><subject>Coronaviruses</subject><subject>Cough</subject><subject>Cough - etiology</subject><subject>Data collection</subject><subject>Demographic aspects</subject><subject>Disease prevention</subject><subject>Distribution</subject><subject>DNA Viruses - isolation & purification</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Etiology</subject><subject>Female</subject><subject>Fever</subject><subject>Genetic aspects</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Health aspects</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infants</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Influenza</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Mycoplasma pneumoniae</subject><subject>Mycoplasma pneumoniae - isolation & purification</subject><subject>Nasopharynx - microbiology</subject><subject>Nasopharynx - virology</subject><subject>Pathogens</subject><subject>Pilot Projects</subject><subject>Pneumonia</subject><subject>Prevention</subject><subject>Prognosis</subject><subject>Respiratory tract infection</subject><subject>Respiratory Tract Infections - diagnosis</subject><subject>Respiratory Tract Infections - drug therapy</subject><subject>Respiratory Tract Infections - microbiology</subject><subject>Respiratory Tract Infections - virology</subject><subject>Risk factors</subject><subject>RNA Viruses - isolation & purification</subject><subject>Severe acute respiratory syndrome</subject><subject>Surveillance</subject><subject>Viral infections</subject><subject>Viruses</subject><subject>Watchful waiting (Medical care)</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk2-L1DAQxoso3nn6DUQDgii4a9qkf9YXwnGcunJy4KlvwzSdbHOkTU3Sxf2ufhjTu71zV-6FFNrw9DfPJJOZJHma0nnKyvTtpR1dD2Y-2B7nNONVmdN7yWG6YNmsyCi7v7M-SB55f0lpzqqieJgcMBbhRZ4dJr9Pg7bGrrQEQ6BvCA66we6vJltwIAM67YOWnlhFPK7RIQE5BiQO_aAdBOs2RPcKZfTriYTRY0PqDelGE_RgkKy1i5q_SvJlI-1gwHdAhh7HzvYaMIYTaCJOBgga--An5bPufQv9G3IR36sW9DtyTAZtbCCtjakDmFkNUzI_ujVqY6CXSHwYm83j5IEC4_HJ9nuUfP9w-u3k0-zs_OPy5PhsJsu8CjNQedlQQCkrvkgpU6AQaF1lZVYomlPKM-Cc1WmpGqRUlahYkaZ5zkoua4XsKHl-7TsY68X2YrzIcsqKeFVVHonlNdFYuBSD0x24jbCgxZVg3UqAi_U1KChXKqtUVTJELkuso8NCqTQvahoFFb3eb7ONdYeNjJVyYPZM9__0uhUruxblouIFL6LBq62Bsz9H9EF02kucKod2vNo3jxtPeRrRF_-gd59uS60gHiB2gY155WQqjos8X6SsKHmk5ndQ8Zn6TcYuVjrqewGv9wIiE_BXWMXe8mJ58fX_2fMf--zLHbZFMKH11oxT5_p9kF-D0lnvHarbIqdUTEN4Uw0xDaHYDmEMe7Z7QbdBN1PH_gCKSTOl</recordid><startdate>20210322</startdate><enddate>20210322</enddate><creator>Li, Jian</creator><creator>Song, Can-Lei</creator><creator>Wang, Tang</creator><creator>Ye, Yu-Long</creator><creator>Du, Jian-Ru</creator><creator>Li, Shu-Hua</creator><creator>Zhu, Jian-Min</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0901-6458</orcidid></search><sort><creationdate>20210322</creationdate><title>Etiological and epidemiological characteristics of severe acute respiratory infection caused by multiple viruses and Mycoplasma pneumoniae in adult patients in Jinshan, Shanghai: A pilot hospital-based surveillance study</title><author>Li, Jian ; Song, Can-Lei ; Wang, Tang ; Ye, Yu-Long ; Du, Jian-Ru ; Li, Shu-Hua ; Zhu, Jian-Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-af57d0aecc849103fafea0b82726f050042a443b17fde00f7ef361155374cbfe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adults</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bacterial infections</topic><topic>Biology and Life Sciences</topic><topic>Children</topic><topic>China</topic><topic>Coronaviruses</topic><topic>Cough</topic><topic>Cough - etiology</topic><topic>Data collection</topic><topic>Demographic aspects</topic><topic>Disease prevention</topic><topic>Distribution</topic><topic>DNA Viruses - isolation & purification</topic><topic>Epidemics</topic><topic>Epidemiology</topic><topic>Etiology</topic><topic>Female</topic><topic>Fever</topic><topic>Genetic aspects</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Health aspects</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infants</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Influenza</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Mycoplasma pneumoniae</topic><topic>Mycoplasma pneumoniae - isolation & purification</topic><topic>Nasopharynx - microbiology</topic><topic>Nasopharynx - virology</topic><topic>Pathogens</topic><topic>Pilot Projects</topic><topic>Pneumonia</topic><topic>Prevention</topic><topic>Prognosis</topic><topic>Respiratory tract infection</topic><topic>Respiratory Tract Infections - diagnosis</topic><topic>Respiratory Tract Infections - drug therapy</topic><topic>Respiratory Tract Infections - microbiology</topic><topic>Respiratory Tract Infections - virology</topic><topic>Risk factors</topic><topic>RNA Viruses - isolation & purification</topic><topic>Severe acute respiratory syndrome</topic><topic>Surveillance</topic><topic>Viral infections</topic><topic>Viruses</topic><topic>Watchful waiting (Medical care)</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jian</creatorcontrib><creatorcontrib>Song, Can-Lei</creatorcontrib><creatorcontrib>Wang, Tang</creatorcontrib><creatorcontrib>Ye, Yu-Long</creatorcontrib><creatorcontrib>Du, Jian-Ru</creatorcontrib><creatorcontrib>Li, Shu-Hua</creatorcontrib><creatorcontrib>Zhu, Jian-Min</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jian</au><au>Song, Can-Lei</au><au>Wang, Tang</au><au>Ye, Yu-Long</au><au>Du, Jian-Ru</au><au>Li, Shu-Hua</au><au>Zhu, Jian-Min</au><au>Lin, Baochuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Etiological and epidemiological characteristics of severe acute respiratory infection caused by multiple viruses and Mycoplasma pneumoniae in adult patients in Jinshan, Shanghai: A pilot hospital-based surveillance study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-03-22</date><risdate>2021</risdate><volume>16</volume><issue>3</issue><spage>e0248750</spage><epage>e0248750</epage><pages>e0248750-e0248750</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Severe acute respiratory infection (SARI) results in a tremendous disease burden worldwide. Available research on active surveillance among hospitalized adult patients suffering from SARI in China is limited. This pilot study aimed to identify associated etiologies and describe the demographic, epidemiological and clinical profiles of hospitalized SARI patients aged over 16 years in Jinshan, Shanghai.
Active surveillance was conducted at 1 sentinel hospital in Jinshan district, Shanghai, from April 2017 to March 2018. Hospitalized SARI patients aged over 16 years old were enrolled, and nasopharyngeal swabs were collected within 24 hours of admission and tested for multiple respiratory viruses (including 18 common viruses) and Mycoplasma pneumoniae with real-time polymerase chain reaction. Demographic, epidemiological and clinical information was obtained from case report forms.
In total, 397 SARI patients were enrolled; the median age was 68 years, and 194 (48.9%) patients were male. A total of 278 (70.0%) patients had at least one underlying chronic medical condition. The most frequent symptoms were cough (99.2%) and sputum production (88.4%). The median duration of hospitalization was 10 days. A total of 250 infection patients (63.0%) were positive for at least one pathogen, of whom 198 (49.9%) were positive for a single pathogen and 52 (13.1%) were positive for multiple pathogens. The pathogens identified most frequently were M. pneumoniae (23.9%, 95/397), followed by adenovirus (AdV) (11.6%, 46/397), influenza virus A/H3N2 (Flu A/H3N2) (11.1%, 44/397), human rhinovirus (HRhV) (8.1%, 32/397), influenza virus B/Yamagata (Flu B/Yamagata) (6.3%, 25/397), pandemic influenza virus A/H1N1 (Flu A/pH1N1) (4.0%, 16/397), parainfluenza virus (PIV) type 1 (2.0%, 8/397), human coronavirus (HCoV) type NL63 (2.0%, 8/397), HCoV 229E (1.5%, 6/397), HCoV HKU1 (1.5%, 6/397), PIV 3 (1.5%, 6/397), human metapneumovirus (HMPV) (1.5%, 6/397), PIV 4 (1.3%, 5/397), HCoV OC43 (1.0%, 4/397), influenza virus B/Victoria (Flu B/Victoria) (0.5%, 2/397), respiratory syncytial virus (RSV) type B (0.5%, 2/397), and human bocavirus (HBoV) (0.3%, 1/397). The seasonality of pathogen-confirmed SARI patients had a bimodal distribution, with the first peak in the summer and the second peak in the winter. Statistically significant differences were observed with respect to the rates of dyspnea, radiographically diagnosed pneumonia and the presence of at least one comorbidity in patients who were infected with only M. pneumoniae, AdV, HRhV, Flu A/H3N2, Flu A /pH1N1 or Flu B/Yamagata. The differences in the positivity rates of the above 6 pathogens among the different age groups were nonsignificant.
M. pneumoniae, AdV and Flu A/H3N2 were the main pathogens detected in hospitalized SARI patients aged over 16 years old in Jinshan district, Shanghai. Our findings highlight the importance of sustained multipathogen surveillance among SARI patients in sentinel hospitals, which can provide useful information on SARI etiologies, epidemiology, and clinical characteristics.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33750952</pmid><doi>10.1371/journal.pone.0248750</doi><tpages>e0248750</tpages><orcidid>https://orcid.org/0000-0003-0901-6458</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-03, Vol.16 (3), p.e0248750-e0248750 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2503637185 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Adults Age Aged Aged, 80 and over Anti-Bacterial Agents - therapeutic use Bacterial infections Biology and Life Sciences Children China Coronaviruses Cough Cough - etiology Data collection Demographic aspects Disease prevention Distribution DNA Viruses - isolation & purification Epidemics Epidemiology Etiology Female Fever Genetic aspects Glucocorticoids - therapeutic use Health aspects Hospitalization Hospitals Humans Infants Infections Infectious diseases Influenza Male Medicine and Health Sciences Microbiology Middle Aged Mycoplasma pneumoniae Mycoplasma pneumoniae - isolation & purification Nasopharynx - microbiology Nasopharynx - virology Pathogens Pilot Projects Pneumonia Prevention Prognosis Respiratory tract infection Respiratory Tract Infections - diagnosis Respiratory Tract Infections - drug therapy Respiratory Tract Infections - microbiology Respiratory Tract Infections - virology Risk factors RNA Viruses - isolation & purification Severe acute respiratory syndrome Surveillance Viral infections Viruses Watchful waiting (Medical care) Young Adult |
| title | Etiological and epidemiological characteristics of severe acute respiratory infection caused by multiple viruses and Mycoplasma pneumoniae in adult patients in Jinshan, Shanghai: A pilot hospital-based surveillance study |
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