Metabolic and behavioral features of acute hyperpurinergia and the maternal immune activation mouse model of autism spectrum disorder

Since 2012, studies in mice, rats, and humans have suggested that abnormalities in purinergic signaling may be a final common pathway for many genetic and environmental causes of autism spectrum disorder (ASD). The current study in mice was conducted to characterize the bioenergetic, metabolomic, br...

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Veröffentlicht in:	PloS one 2021-03, Vol.16 (3), p.e0248771-e0248771
Hauptverfasser:	Zolkipli-Cunningham, Zarazuela, Naviaux, Jane C, Nakayama, Tomohiro, Hirsch, Charlotte M, Monk, Jonathan M, Li, Kefeng, Wang, Lin, Le, Thuy P, Meinardi, Simone, Blake, Donald R, Naviaux, Robert K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adenosine Triphosphate - metabolism Animal models Animals ATP Autism Autism Spectrum Disorder - metabolism Behavior Behavior, Animal Bioenergetics Biology and Life Sciences Body Temperature Chemistry Chemokines - metabolism Computer programs Corticosterone - metabolism Cunningham, Jane Data analysis Diagnosis Disease Models, Animal Drafting software Editing Energy Metabolism Gene expression Genetic aspects Hypotheses Immune response Injection Laboratory animals Medicine Metabolic disorders Metabolites Metabolomics Methodology Mice Mice, Inbred C57BL Mitochondria Mitochondria - metabolism Mitochondrial DNA Mutation Neurosciences Pediatrics Physical Sciences Physiological aspects Purines - metabolism Reviews Social Sciences Software Uric acid Visualization
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