Evaluation of the effectiveness of macaíba palm seed kernel (Acrocomia intumescens drude) on anxiolytic activity, memory preservation and oxidative stress in the brain of dyslipidemic rats
Macaíba palm seed kernel is a source of lipids and phenolic compounds. The objective of this study was to evaluate the effects of macaíba palm seed kernel on anxiety, memory, and oxidative stress in the brain of health and dyslipidemic rats. Forty rats were used, divided into 4 groups (n = 10 each):...
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| creator | de França Silva, Roberta Cristina de Souza, Mikaelle Albuquerque da Silva, Jaielison Yandro Pereira Ponciano, Carolina da Silva Bordin Viera, Vanessa de Menezes Santos Bertozzo, Camila Carolina Guerra, Gerlane Coelho de Souza Araújo, Daline Fernandes da Conceição, Marta Maria Querino Dias, Celina de Castro Oliveira, Maria Elieidy Soares, Juliana Kessia Barbosa |
| description | Macaíba palm seed kernel is a source of lipids and phenolic compounds. The objective of this study was to evaluate the effects of macaíba palm seed kernel on anxiety, memory, and oxidative stress in the brain of health and dyslipidemic rats. Forty rats were used, divided into 4 groups (n = 10 each): control (CONT), dyslipidemic (DG), kernel (KG), and Dyslipidemic kernel (DKG). Dyslipidemia was induced using a high fat emulsion for 14 days before treatment. KG and DKG received 1000 mg/kg of macaíba palm seed kernel per gavage for 28 days. After treatment, anxiety tests were carried out using the Open Field Test (OFT), Elevated Plus Maze (EPM), and the Object Recognition Test (ORT) to assess memory. In the animals' brain tissue, levels of malondialdehyde (MDA) and total glutathione (GSH) were quantified to determine oxidative stress. The data were treated with Two Way ANOVA followed by Tukey (p |
| doi_str_mv | 10.1371/journal.pone.0246184 |
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The objective of this study was to evaluate the effects of macaíba palm seed kernel on anxiety, memory, and oxidative stress in the brain of health and dyslipidemic rats. Forty rats were used, divided into 4 groups (n = 10 each): control (CONT), dyslipidemic (DG), kernel (KG), and Dyslipidemic kernel (DKG). Dyslipidemia was induced using a high fat emulsion for 14 days before treatment. KG and DKG received 1000 mg/kg of macaíba palm seed kernel per gavage for 28 days. After treatment, anxiety tests were carried out using the Open Field Test (OFT), Elevated Plus Maze (EPM), and the Object Recognition Test (ORT) to assess memory. In the animals' brain tissue, levels of malondialdehyde (MDA) and total glutathione (GSH) were quantified to determine oxidative stress. The data were treated with Two Way ANOVA followed by Tukey (p <0.05). Results demonstrated that the animals treated with kernel realized more rearing. DG and KG groomed less compared with CONT and DKG compared with all groups in OFT. KG spent more time in aversive open arms compared with CONT and DKG compared with all groups in EPM. Only DKG spent more time in the central area in EMP. KG and DKG showed a reduction in the exploration rate and MDA values (p <0.05). Data showed that macaíba palm seed kernel consumption induced anxiolytic-like behaviour and decreased lipids peroxidation in rats' brains. On the other hand, this consumption by healthy and dyslipidemic animals compromises memory.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0246184</identifier><identifier>PMID: 33730037</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animal behavior ; Animal cognition ; Animals ; Anxiety ; Behavior ; Biology and Life Sciences ; Brain ; Carotenoids ; Editing ; Fatty acids ; Flavonoids ; Kernels ; Lipids ; Long term memory ; Medicine and Health Sciences ; Memory ; Metabolic disorders ; Methodology ; Olive oil ; Oxidative stress ; Palmitic acid ; Photonics ; Physical Sciences ; Reviews ; Short term memory ; Visualization</subject><ispartof>PloS one, 2021-03, Vol.16 (3), p.e0246184-e0246184</ispartof><rights>2021 de França Silva et al. 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The objective of this study was to evaluate the effects of macaíba palm seed kernel on anxiety, memory, and oxidative stress in the brain of health and dyslipidemic rats. Forty rats were used, divided into 4 groups (n = 10 each): control (CONT), dyslipidemic (DG), kernel (KG), and Dyslipidemic kernel (DKG). Dyslipidemia was induced using a high fat emulsion for 14 days before treatment. KG and DKG received 1000 mg/kg of macaíba palm seed kernel per gavage for 28 days. After treatment, anxiety tests were carried out using the Open Field Test (OFT), Elevated Plus Maze (EPM), and the Object Recognition Test (ORT) to assess memory. In the animals' brain tissue, levels of malondialdehyde (MDA) and total glutathione (GSH) were quantified to determine oxidative stress. The data were treated with Two Way ANOVA followed by Tukey (p <0.05). Results demonstrated that the animals treated with kernel realized more rearing. DG and KG groomed less compared with CONT and DKG compared with all groups in OFT. KG spent more time in aversive open arms compared with CONT and DKG compared with all groups in EPM. Only DKG spent more time in the central area in EMP. KG and DKG showed a reduction in the exploration rate and MDA values (p <0.05). Data showed that macaíba palm seed kernel consumption induced anxiolytic-like behaviour and decreased lipids peroxidation in rats' brains. On the other hand, this consumption by healthy and dyslipidemic animals compromises memory.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33730037</pmid><doi>10.1371/journal.pone.0246184</doi><orcidid>https://orcid.org/0000-0002-4234-1490</orcidid><orcidid>https://orcid.org/0000-0002-9297-654X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animal behavior Animal cognition Animals Anxiety Behavior Biology and Life Sciences Brain Carotenoids Editing Fatty acids Flavonoids Kernels Lipids Long term memory Medicine and Health Sciences Memory Metabolic disorders Methodology Olive oil Oxidative stress Palmitic acid Photonics Physical Sciences Reviews Short term memory Visualization |
| title | Evaluation of the effectiveness of macaíba palm seed kernel (Acrocomia intumescens drude) on anxiolytic activity, memory preservation and oxidative stress in the brain of dyslipidemic rats |
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