Therapeutic targeting of measles virus polymerase with ERDRP-0519 suppresses all RNA synthesis activity

Morbilliviruses, such as measles virus (MeV) and canine distemper virus (CDV), are highly infectious members of the paramyxovirus family. MeV is responsible for major morbidity and mortality in non-vaccinated populations. ERDRP-0519, a pan-morbillivirus small molecule inhibitor for the treatment of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS pathogens 2021-02, Vol.17 (2), p.e1009371-e1009371
Hauptverfasser:	Cox, Robert M, Sourimant, Julien, Govindarajan, Mugunthan, Natchus, Michael G, Plemper, Richard K
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and life sciences Canine distemper Conformation COVID-19 Infections Inhibitors Lead compounds Life Sciences Locking Lyssavirus Measles Medicine and Health Sciences Mutation Pathogens Proteins Proteomics Rabies Research and analysis methods Respiratory syncytial virus Severe acute respiratory syndrome coronavirus 2 Stomatitis Therapeutic targets Transcription Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!