TLR7 agonist, N6-LS and PGT121 delayed viral rebound in SHIV-infected macaques after antiretroviral therapy interruption

Toll-like receptor 7 (TLR7) agonist and PGT121 (broadly neutralizing antibody, bnAb) administration previously delayed viral rebound and induced SHIV remission. We evaluated the impact of GS-986 (TLR7 agonist) and dual bnAbs on viral rebound after antiretroviral therapy (ART) interruption. Rhesus ma...

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Veröffentlicht in:	PLoS pathogens 2021-02, Vol.17 (2), p.e1009339-e1009339
Hauptverfasser:	Hsu, Denise C, Schuetz, Alexandra, Imerbsin, Rawiwan, Silsorn, Decha, Pegu, Amarendra, Inthawong, Dutsadee, Sopanaporn, Jumpol, Visudhiphan, Pornsuk, Chuenarom, Weerawan, Keawboon, Boot, Shi, Wei, Robb, Merlin L, Mascola, John R, Geleziunas, Romas, Koup, Richard A, Barouch, Dan H, Michael, Nelson L, Vasan, Sandhya
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animals Antibodies Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Antiviral activity Binding sites Biology and life sciences CD4 antigen Colon Colonies Colony-stimulating factor Cytokines Deoxyribonucleic acid DNA Dosage Drug dosages Drug therapy Glycan Granulocyte colony-stimulating factor Granulocyte-macrophage colony stimulating factor Granulocytes HIV Human immunodeficiency virus Inflammation Interferon Interleukin 1 Interleukin 10 Interleukin 12 Interleukin 13 Interleukin 15 Interleukin 18 Interleukin 2 Interleukin 6 Intravenous administration Leukocytes (granulocytic) Lymph nodes Lymphatic system Lymphocytes Macrophage inflammatory protein Medicine and Health Sciences Monocytes Plasma Proteins Receptors Research and Analysis Methods Tumor necrosis factor-TNF
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