Arrhythmogenic effects of ultra-long and bistable cardiac action potentials

Contemporary accounts of the initiation of cardiac arrhythmias typically rely on after-depolarizations as the trigger for reentrant activity. The after-depolarizations are usually triggered by calcium entry or spontaneous release within the cells of the myocardium or the conduction system. Here we p...

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Veröffentlicht in:	PLoS computational biology 2021-02, Vol.17 (2), p.e1008683-e1008683
Hauptverfasser:	Heitmann, Stewart, Shpak, Anton, Vandenberg, Jamie I, Hill, Adam P
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Atria Biology and Life Sciences Calcium Calcium channels (L-type) Calcium channels (voltage-gated) Cardiac arrhythmia Extreme values Fibrosis Heart Medicine and Health Sciences Myocytes Physical Sciences Ventricle
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