The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration

The Hippo-YAP pathway responds to diverse environmental cues to manage tissue homeostasis, organ regeneration, tumorigenesis, and immunity. However, how phosphatase(s) directly target Yes-associated protein (YAP) and determine its physiological activity are still inconclusive. Here, we utilized an u...

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Veröffentlicht in:	PLoS biology 2021-02, Vol.19 (2), p.e3001122
Hauptverfasser:	Zhou, Ruyuan, Wu, Qirou, Wang, Mengqiu, Irani, Seema, Li, Xiao, Zhang, Qian, Meng, Fansen, Liu, Shengduo, Zhang, Fei, Wu, Liming, Lin, Xia, Wang, Xiaojian, Zou, Jian, Song, Hai, Qin, Jun, Liang, Tingbo, Feng, Xin-Hua, Zhang, Yan Jessie, Xu, Pinglong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Animals Biology and Life Sciences Cell Proliferation Cells, Cultured Cellular signal transduction Colitis - pathology Cytoplasm Dephosphorylation Doxycycline Genetic aspects Genetic transcription Health aspects Humans Identification and classification Insects Intestine Intestines - physiology Kinases Liver Liver Regeneration - physiology Localization Magnesium Mammals Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Knockout Organoids Phenotypes Phosphatase Phosphatases Phosphorylation Physiological aspects Physiological effects Physiology Protein phosphatase Protein Phosphatase 2C - genetics Protein Phosphatase 2C - metabolism Proteins Regeneration Regeneration - physiology Regulation Regulatory mechanisms (biology) Research and Analysis Methods Serine Signal Transduction Signaling Threonine Transcription Transcription Factors - metabolism Tumor suppressor genes YAP-Signaling Proteins Yes-associated protein
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