Epigenome wide association study of response to methotrexate in early rheumatoid arthritis patients

To identify differentially methylated positions (DMPs) and regions (DMRs) that predict response to Methotrexate (MTX) in early rheumatoid arthritis (RA) patients. DNA from baseline peripheral blood mononuclear cells was extracted from 72 RA patients. DNA methylation, quantified using the Infinium Me...

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Veröffentlicht in:	PloS one 2021-03, Vol.16 (3), p.e0247709-e0247709
Hauptverfasser:	Gosselt, Helen R, Vallerga, Costanza L, Mandaviya, Pooja R, Lubberts, Erik, Hazes, Johanna M W, de Jonge, Robert, Heil, Sandra G
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis Biology and life sciences Care and treatment Chemistry Cost analysis Deoxyribonucleic acid DNA DNA methylation DNA probes Editing Funding Gastroenterology Genetic aspects Health care facilities Internal medicine Joints (anatomy) Lymphocytes Medical ethics Medicine Medicine and Health Sciences Metabolism Methodology Methotrexate Physical Sciences Physiological aspects Probes Quality control Research and Analysis Methods Response rates Rheumatoid arthritis Rheumatology Supervision Testing
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