Effects of relocation on immunological and physiological measures in female squirrel monkeys (Saimiri boliviensis boliviensis)
In the present study, we have quantified the effects of transport, relocation and acclimate/adapt to their new surroundings on female squirrel monkey. These responses are measured in blood samples obtained from squirrel monkeys, at different time points relative to their relocation from their old ho...
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| creator | Nehete, Pramod N Nehete, Bharti P Wilkerson, Greg K Schapiro, Steve J Williams, Lawrence E |
| description | In the present study, we have quantified the effects of transport, relocation and acclimate/adapt to their new surroundings on female squirrel monkey. These responses are measured in blood samples obtained from squirrel monkeys, at different time points relative to their relocation from their old home to their new home. A group of squirrel monkeys we transported, by truck, for approximately 10 hours. Peripheral blood mononuclear cells (PBMCs) were assayed in order to evaluate the phenotype of lymphocyte subsets by flow, mitogen-specific immune responses of PBMCs in vitro, and levels of cytokines at various time points including immediately before transport, immediately upon arrival, and after approximately 150 days of acclimation. We observed significant changes in T cells and subsets, NK and B cells (CD4+, CD8+, CD4+/CD8+, CD16+, and CD20+). Mitogen specific (e.g. PHA, PWM and LPS) proliferation responses, IFN-γ by ELISPOT assay, and cytokines (IL-2, IL-4 and VEGF) significant changes were observed. Changes seen in the serum chemistry measurements mostly complement those seen in the hematology data. The specific goal was to empirically assess the effects of relocation stress in squirrel monkeys in terms of changes in the numbers and functions of various leukocyte subsets in the blood and the amount of time required for acclimating to their new environment. Such data will help to determine when newly arrived animals become available for use in research studies. |
| doi_str_mv | 10.1371/journal.pone.0240705 |
| format | Article |
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These responses are measured in blood samples obtained from squirrel monkeys, at different time points relative to their relocation from their old home to their new home. A group of squirrel monkeys we transported, by truck, for approximately 10 hours. Peripheral blood mononuclear cells (PBMCs) were assayed in order to evaluate the phenotype of lymphocyte subsets by flow, mitogen-specific immune responses of PBMCs in vitro, and levels of cytokines at various time points including immediately before transport, immediately upon arrival, and after approximately 150 days of acclimation. We observed significant changes in T cells and subsets, NK and B cells (CD4+, CD8+, CD4+/CD8+, CD16+, and CD20+). Mitogen specific (e.g. PHA, PWM and LPS) proliferation responses, IFN-γ by ELISPOT assay, and cytokines (IL-2, IL-4 and VEGF) significant changes were observed. Changes seen in the serum chemistry measurements mostly complement those seen in the hematology data. 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Such data will help to determine when newly arrived animals become available for use in research studies.</description><subject>Acquired immune deficiency syndrome</subject><subject>Agriculture</subject><subject>AIDS</subject><subject>Alzheimer's disease</subject><subject>Animal experimentation</subject><subject>Animal welfare</subject><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Blood tests</subject><subject>Cancer</subject><subject>Chemistry</subject><subject>Creutzfeldt-Jakob disease</subject><subject>Disease</subject><subject>Editing</subject><subject>Environmental conditions</subject><subject>Evaluation</subject><subject>Flow cytometry</subject><subject>Funding</subject><subject>Giardia</subject><subject>Graduate schools</subject><subject>Graduate studies</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Immunology</subject><subject>Laboratory animals</subject><subject>Malaria</subject><subject>Medical 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The specific goal was to empirically assess the effects of relocation stress in squirrel monkeys in terms of changes in the numbers and functions of various leukocyte subsets in the blood and the amount of time required for acclimating to their new environment. Such data will help to determine when newly arrived animals become available for use in research studies.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33635869</pmid><doi>10.1371/journal.pone.0240705</doi><tpages>e0240705</tpages><orcidid>https://orcid.org/0000-0002-2815-2677</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acquired immune deficiency syndrome Agriculture AIDS Alzheimer's disease Animal experimentation Animal welfare Animals Biology and Life Sciences Blood tests Cancer Chemistry Creutzfeldt-Jakob disease Disease Editing Environmental conditions Evaluation Flow cytometry Funding Giardia Graduate schools Graduate studies HIV Human immunodeficiency virus Immunology Laboratory animals Malaria Medical research Medicine Medicine and Health Sciences Monkeys Monkeys & apes Neurodegenerative diseases Pathogenesis Physiological effects Physiology Primates Relocation Research and Analysis Methods Reviews Squirrels Vector-borne diseases |
| title | Effects of relocation on immunological and physiological measures in female squirrel monkeys (Saimiri boliviensis boliviensis) |
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