A multi-omic investigation of male lower urinary tract symptoms: Potential role for JC virus

Male lower urinary tract symptoms (LUTS) comprise a common syndrome of aging that negatively impacts quality of life. The etiology of LUTS is multifactorial, involving benign prostatic hyperplasia, smooth muscle and neurologic dysfunction, inflammation, sexually transmitted infections, fibrosis, and...

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Veröffentlicht in:	PloS one 2021-02, Vol.16 (2), p.e0246266
Hauptverfasser:	Thomas, Samuel, Dunn, Christopher D, Campbell, Lewis J, Strand, Douglas W, Vezina, Chad M, Bjorling, Dale E, Penniston, Kristina L, Li, Lingjun, Ricke, William A, Goldberg, Tony L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amino acids Antioxidants Biology and Life Sciences Case-Control Studies Catheters Complications and side effects Dengue Dengue fever Deoxyribonucleic acid DNA Editing Funding Genetic aspects Genetic testing Glutathione Health aspects Health care facilities High-Throughput Nucleotide Sequencing Humans Infections JC Virus - genetics JC Virus - metabolism JC Virus - pathogenicity Kidney diseases Lipids Lower Urinary Tract Symptoms - etiology Lower Urinary Tract Symptoms - metabolism Lower Urinary Tract Symptoms - microbiology Lower Urinary Tract Symptoms - virology Male Medical research Medicine and Health Sciences Metabolism Metabolites Metabolomics Methodology Middle Aged Nervous system diseases Oxidative stress Pain Physiological aspects Polymerase Chain Reaction Polyoma virus Polyomavirus Infections - complications Polyomavirus Infections - virology Prostate Public health Research and Analysis Methods Risk factors Surgery Tandem Mass Spectrometry Thomas, Christopher Toxicology Transplants & implants Urinary tract Urinary tract infections Urination Urine Urogenital system Urology Vector-borne diseases Viral infections Viruses
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