Effect of therapeutic hypothermia on renal and myocardial function in asphyxiated (near) term neonates: A systematic review and meta-analysis
Therapeutic hypothermia (TH) is a well-established neuroprotective therapy applied in (near) term asphyxiated infants. However, little is known regarding the effects of TH on renal and/or myocardial function. To describe the short- and long-term effects of TH on renal and myocardial function in asph...
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| description | Therapeutic hypothermia (TH) is a well-established neuroprotective therapy applied in (near) term asphyxiated infants. However, little is known regarding the effects of TH on renal and/or myocardial function.
To describe the short- and long-term effects of TH on renal and myocardial function in asphyxiated (near) term neonates.
An electronic search strategy incorporating MeSH terms and keywords was performed in October 2019 and updated in June 2020 using PubMed and Cochrane databases. Inclusion criteria consisted of a RCT or observational cohort design, intervention with TH in a setting of perinatal asphyxia and available long-term results on renal and myocardial function. We performed a meta-analysis and heterogeneity and sensitivity analyses using a random effects model. Subgroup analysis was performed on the method of cooling.
Of the 107 studies identified on renal function, 9 were included. None of the studies investigated the effects of TH on long-term renal function after perinatal asphyxia. The nine included studies described the effect of TH on the incidence of acute kidney injury (AKI) after perinatal asphyxia. Meta-analysis showed a significant difference between the incidence of AKI in neonates treated with TH compared to the control group (RR = 0.81; 95% CI 0.67-0.98; p = 0.03). No studies were found investigating the long-term effects of TH on myocardial function after neonatal asphyxia. Possible short-term beneficial effects were presented in 4 out of 5 identified studies, as observed by significant reductions in cardiac biomarkers and less findings of myocardial dysfunction on ECG and cardiac ultrasound.
TH in asphyxiated neonates reduces the incidence of AKI, an important risk factor for chronic kidney damage, and thus is potentially renoprotective. No studies were found on the long-term effects of TH on myocardial function. Short-term outcome studies suggest a cardioprotective effect. |
| doi_str_mv | 10.1371/journal.pone.0247403 |
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To describe the short- and long-term effects of TH on renal and myocardial function in asphyxiated (near) term neonates.
An electronic search strategy incorporating MeSH terms and keywords was performed in October 2019 and updated in June 2020 using PubMed and Cochrane databases. Inclusion criteria consisted of a RCT or observational cohort design, intervention with TH in a setting of perinatal asphyxia and available long-term results on renal and myocardial function. We performed a meta-analysis and heterogeneity and sensitivity analyses using a random effects model. Subgroup analysis was performed on the method of cooling.
Of the 107 studies identified on renal function, 9 were included. None of the studies investigated the effects of TH on long-term renal function after perinatal asphyxia. The nine included studies described the effect of TH on the incidence of acute kidney injury (AKI) after perinatal asphyxia. Meta-analysis showed a significant difference between the incidence of AKI in neonates treated with TH compared to the control group (RR = 0.81; 95% CI 0.67-0.98; p = 0.03). No studies were found investigating the long-term effects of TH on myocardial function after neonatal asphyxia. Possible short-term beneficial effects were presented in 4 out of 5 identified studies, as observed by significant reductions in cardiac biomarkers and less findings of myocardial dysfunction on ECG and cardiac ultrasound.
TH in asphyxiated neonates reduces the incidence of AKI, an important risk factor for chronic kidney damage, and thus is potentially renoprotective. No studies were found on the long-term effects of TH on myocardial function. Short-term outcome studies suggest a cardioprotective effect.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0247403</identifier><identifier>PMID: 33630895</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Aorta ; Aortic arch ; Asphyxia ; Asphyxia - physiopathology ; Asphyxia neonatorum ; Asphyxia Neonatorum - physiopathology ; Bias ; Biology and Life Sciences ; Brain damage ; Cardiomyopathies - physiopathology ; Cardiomyopathy ; Care and treatment ; Confidence intervals ; Congestive heart failure ; Cooling ; Coronary artery disease ; Disabilities ; Drowning ; Encephalopathy ; Heart ; Heart diseases ; Humans ; Hypothermia ; Hypothermia, Induced ; Hypothermia, Induced - adverse effects ; Hypoxia ; Industrialized nations ; Infant, Newborn ; Intellectual disabilities ; Ischemia ; Keywords ; Kidney - physiopathology ; Kidney diseases ; Kidneys ; Medical research ; Medicine and Health Sciences ; Meta-analysis ; Myocardium - pathology ; Neonates ; Newborn babies ; Paralysis ; Patient outcomes ; Pediatric research ; Physical Sciences ; Quality assessment ; Quality control ; Renal failure ; Renal function ; Renal insufficiency ; Research and Analysis Methods ; Risk factors ; Seizures ; Statistical analysis ; Surgery ; Systematic review</subject><ispartof>PloS one, 2021-02, Vol.16 (2), p.e0247403</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 van Wincoop et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 van Wincoop et al 2021 van Wincoop et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c659t-5b059dd1b40d979edd1e1f9a5dcd72381b0545dde9ce4ce5e96beb268e81594c3</citedby><cites>FETCH-LOGICAL-c659t-5b059dd1b40d979edd1e1f9a5dcd72381b0545dde9ce4ce5e96beb268e81594c3</cites><orcidid>0000-0001-5116-6092</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906340/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906340/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33630895$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Wincoop, Maureen</creatorcontrib><creatorcontrib>de Bijl-Marcus, Karen</creatorcontrib><creatorcontrib>Lilien, Marc</creatorcontrib><creatorcontrib>van den Hoogen, Agnes</creatorcontrib><creatorcontrib>Groenendaal, Floris</creatorcontrib><title>Effect of therapeutic hypothermia on renal and myocardial function in asphyxiated (near) term neonates: A systematic review and meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Therapeutic hypothermia (TH) is a well-established neuroprotective therapy applied in (near) term asphyxiated infants. However, little is known regarding the effects of TH on renal and/or myocardial function.
To describe the short- and long-term effects of TH on renal and myocardial function in asphyxiated (near) term neonates.
An electronic search strategy incorporating MeSH terms and keywords was performed in October 2019 and updated in June 2020 using PubMed and Cochrane databases. Inclusion criteria consisted of a RCT or observational cohort design, intervention with TH in a setting of perinatal asphyxia and available long-term results on renal and myocardial function. We performed a meta-analysis and heterogeneity and sensitivity analyses using a random effects model. Subgroup analysis was performed on the method of cooling.
Of the 107 studies identified on renal function, 9 were included. None of the studies investigated the effects of TH on long-term renal function after perinatal asphyxia. The nine included studies described the effect of TH on the incidence of acute kidney injury (AKI) after perinatal asphyxia. Meta-analysis showed a significant difference between the incidence of AKI in neonates treated with TH compared to the control group (RR = 0.81; 95% CI 0.67-0.98; p = 0.03). No studies were found investigating the long-term effects of TH on myocardial function after neonatal asphyxia. Possible short-term beneficial effects were presented in 4 out of 5 identified studies, as observed by significant reductions in cardiac biomarkers and less findings of myocardial dysfunction on ECG and cardiac ultrasound.
TH in asphyxiated neonates reduces the incidence of AKI, an important risk factor for chronic kidney damage, and thus is potentially renoprotective. No studies were found on the long-term effects of TH on myocardial function. Short-term outcome studies suggest a cardioprotective effect.</description><subject>Animals</subject><subject>Aorta</subject><subject>Aortic arch</subject><subject>Asphyxia</subject><subject>Asphyxia - physiopathology</subject><subject>Asphyxia neonatorum</subject><subject>Asphyxia Neonatorum - physiopathology</subject><subject>Bias</subject><subject>Biology and Life Sciences</subject><subject>Brain damage</subject><subject>Cardiomyopathies - physiopathology</subject><subject>Cardiomyopathy</subject><subject>Care and treatment</subject><subject>Confidence intervals</subject><subject>Congestive heart failure</subject><subject>Cooling</subject><subject>Coronary artery disease</subject><subject>Disabilities</subject><subject>Drowning</subject><subject>Encephalopathy</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Hypothermia</subject><subject>Hypothermia, Induced</subject><subject>Hypothermia, Induced - adverse effects</subject><subject>Hypoxia</subject><subject>Industrialized nations</subject><subject>Infant, Newborn</subject><subject>Intellectual disabilities</subject><subject>Ischemia</subject><subject>Keywords</subject><subject>Kidney - physiopathology</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Myocardium - pathology</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Paralysis</subject><subject>Patient outcomes</subject><subject>Pediatric research</subject><subject>Physical Sciences</subject><subject>Quality assessment</subject><subject>Quality control</subject><subject>Renal failure</subject><subject>Renal function</subject><subject>Renal insufficiency</subject><subject>Research and Analysis Methods</subject><subject>Risk factors</subject><subject>Seizures</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Systematic review</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUs1u1DAQjhCIloU3QGCJSzns4sQ_iXtAWlUFKlXiAmfLa092vUrsYCeFPETfuU43rbqo8sH2zPfjGU-Wvc_xKidl_mXvh-BUs-q8gxUuaEkxeZGd5oIUS15g8vLJ-SR7E-MeY0Yqzl9nJ4RwgivBTrPby7oG3SNfo34HQXUw9Faj3dj56d5ahbxDAZITUs6gdvRaBWPTtR6c7m3KWodU7HbjP6t6MOjMgQqfUZ_YyIF3KRjP0RrFMfbQqkk-wI2FvwdB6NVSJfkx2vg2e1WrJsK7eV9kv79d_rr4sbz--f3qYn291JyJfsk2mAlj8g3FRpQC0hHyWihmtCkLUuUpT5kxIDRQDQwE38Cm4BVUORNUk0X28aDbNT7KuZNRFlQQyhO3TIirA8J4tZddsK0Ko_TKyvuAD1upQiqlAckqnRc1Kw3WhCpWVAWhFSYGDC95DSRpfZ3dhk0LRoPrg2qORI8zzu7k1t_IUmBO0rcusrNZIPg_A8RetjZqaBqV-jvcv5sWosJi8vr0H_T56mbUVqUCrKt98tWTqFxzRjApKzHZrp5BpWWgtTqNXW1T_IhADwQdfIwB6scacyynoX14jJyGVs5Dm2gfnvbnkfQwpeQO5tXsDA</recordid><startdate>20210225</startdate><enddate>20210225</enddate><creator>van Wincoop, Maureen</creator><creator>de Bijl-Marcus, Karen</creator><creator>Lilien, Marc</creator><creator>van den Hoogen, Agnes</creator><creator>Groenendaal, Floris</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5116-6092</orcidid></search><sort><creationdate>20210225</creationdate><title>Effect of therapeutic hypothermia on renal and myocardial function in asphyxiated (near) term neonates: A systematic review and meta-analysis</title><author>van Wincoop, Maureen ; de Bijl-Marcus, Karen ; Lilien, Marc ; van den Hoogen, Agnes ; Groenendaal, Floris</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c659t-5b059dd1b40d979edd1e1f9a5dcd72381b0545dde9ce4ce5e96beb268e81594c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Aorta</topic><topic>Aortic arch</topic><topic>Asphyxia</topic><topic>Asphyxia - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Wincoop, Maureen</au><au>de Bijl-Marcus, Karen</au><au>Lilien, Marc</au><au>van den Hoogen, Agnes</au><au>Groenendaal, Floris</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of therapeutic hypothermia on renal and myocardial function in asphyxiated (near) term neonates: A systematic review and meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-02-25</date><risdate>2021</risdate><volume>16</volume><issue>2</issue><spage>e0247403</spage><pages>e0247403-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Therapeutic hypothermia (TH) is a well-established neuroprotective therapy applied in (near) term asphyxiated infants. However, little is known regarding the effects of TH on renal and/or myocardial function.
To describe the short- and long-term effects of TH on renal and myocardial function in asphyxiated (near) term neonates.
An electronic search strategy incorporating MeSH terms and keywords was performed in October 2019 and updated in June 2020 using PubMed and Cochrane databases. Inclusion criteria consisted of a RCT or observational cohort design, intervention with TH in a setting of perinatal asphyxia and available long-term results on renal and myocardial function. We performed a meta-analysis and heterogeneity and sensitivity analyses using a random effects model. Subgroup analysis was performed on the method of cooling.
Of the 107 studies identified on renal function, 9 were included. None of the studies investigated the effects of TH on long-term renal function after perinatal asphyxia. The nine included studies described the effect of TH on the incidence of acute kidney injury (AKI) after perinatal asphyxia. Meta-analysis showed a significant difference between the incidence of AKI in neonates treated with TH compared to the control group (RR = 0.81; 95% CI 0.67-0.98; p = 0.03). No studies were found investigating the long-term effects of TH on myocardial function after neonatal asphyxia. Possible short-term beneficial effects were presented in 4 out of 5 identified studies, as observed by significant reductions in cardiac biomarkers and less findings of myocardial dysfunction on ECG and cardiac ultrasound.
TH in asphyxiated neonates reduces the incidence of AKI, an important risk factor for chronic kidney damage, and thus is potentially renoprotective. No studies were found on the long-term effects of TH on myocardial function. Short-term outcome studies suggest a cardioprotective effect.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33630895</pmid><doi>10.1371/journal.pone.0247403</doi><orcidid>https://orcid.org/0000-0001-5116-6092</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Aorta Aortic arch Asphyxia Asphyxia - physiopathology Asphyxia neonatorum Asphyxia Neonatorum - physiopathology Bias Biology and Life Sciences Brain damage Cardiomyopathies - physiopathology Cardiomyopathy Care and treatment Confidence intervals Congestive heart failure Cooling Coronary artery disease Disabilities Drowning Encephalopathy Heart Heart diseases Humans Hypothermia Hypothermia, Induced Hypothermia, Induced - adverse effects Hypoxia Industrialized nations Infant, Newborn Intellectual disabilities Ischemia Keywords Kidney - physiopathology Kidney diseases Kidneys Medical research Medicine and Health Sciences Meta-analysis Myocardium - pathology Neonates Newborn babies Paralysis Patient outcomes Pediatric research Physical Sciences Quality assessment Quality control Renal failure Renal function Renal insufficiency Research and Analysis Methods Risk factors Seizures Statistical analysis Surgery Systematic review |
| title | Effect of therapeutic hypothermia on renal and myocardial function in asphyxiated (near) term neonates: A systematic review and meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T04%3A41%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20therapeutic%20hypothermia%20on%20renal%20and%20myocardial%20function%20in%20asphyxiated%20(near)%20term%20neonates:%20A%20systematic%20review%20and%20meta-analysis&rft.jtitle=PloS%20one&rft.au=van%20Wincoop,%20Maureen&rft.date=2021-02-25&rft.volume=16&rft.issue=2&rft.spage=e0247403&rft.pages=e0247403-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0247403&rft_dat=%3Cgale_plos_%3EA653037890%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2493460547&rft_id=info:pmid/33630895&rft_galeid=A653037890&rft_doaj_id=oai_doaj_org_article_58c12f57d0c34a528234803ded676fe3&rfr_iscdi=true |