Human cytomegalovirus infection among treatment-naive HIV-1 infected patients in Ethiopia
Subclinical human cytomegalovirus (HCMV) replication is associated with immune dysfunction in immuno-suppressed antiretroviral therapy (ART) naive HIV infected individuals. No data is documented in Ethiopia so far concerning HCMV co-infection among HIV infected individuals. Hence, this study was aim...
Gespeichert in:
| Veröffentlicht in: | PloS one 2021-02, Vol.16 (2), p.e0247264-e0247264 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0247264 |
|---|---|
| container_issue | 2 |
| container_start_page | e0247264 |
| container_title | PloS one |
| container_volume | 16 |
| creator | Kiros, Mulugeta Geteneh, Alene Andualem, Henok Alemu, Derbie Tesfaye, Abebech Tefera, Dessalegne Abeje Mihret, Adane Alemayehu, Dawit Hailu Mulu, Andargachew |
| description | Subclinical human cytomegalovirus (HCMV) replication is associated with immune dysfunction in immuno-suppressed antiretroviral therapy (ART) naive HIV infected individuals. No data is documented in Ethiopia so far concerning HCMV co-infection among HIV infected individuals. Hence, this study was aimed at generating data regarding the prevalence of active HCMV infection among treatment-naive HIV-infected individuals from Ethiopia. For this purpose, we enrolled 97 treatment-naive HIV infected study subjects in Addis Ababa from June to December 2018. ELISA and conventional PCR were performed consecutively to detect HCMV specific IgM antibody and HCMV DNA respectively. Of the 97 study subjects, 12 (12.4%) were positive for anti-CMV IgM antibodies but were not confirmed by PCR. With regard to the PCR positivity, 4/97 (4.1%) samples were positive for HCMV DNA. No statically significant associations were found between the dependent and independent variables. The presence of HCMV DNA in the current study highlights the need for a routine laboratory diagnosis for preventing HCMV disease among HIV-infected individuals early. Besides, the use of anti-CMV therapy for these CMV viremic individuals is also recommended as this can reduce the burden of CMV complications and consecutively prolonging the life of HIV infected individuals. |
| doi_str_mv | 10.1371/journal.pone.0247264 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2491015674</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A652227852</galeid><doaj_id>oai_doaj_org_article_590d1a05d55e49c3b17c7b007b4662a4</doaj_id><sourcerecordid>A652227852</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-f5995fcfd7090ae22bfb8499f90400af52b303f9e0c41c094089d3672c4ff9fe3</originalsourceid><addsrcrecordid>eNqNk11r2zAUhs3YWLtu_2BshsHYLpIdfVnRzaCUbgkUCvso7ErIspQo2FZqyWH995MXt8SjF0MXFtLzvsc6H1n2GsEcEY4-bX3ftaqe73xr5oApxwV9kp0iQfCswECeHu1PshchbAEYWRTF8-yEkAKAMn6a_Vr2jWpzfRd9Y9aq9nvX9SF3rTU6Ot_mqvHtOo-dUbExbZy1yu1NvlzdzNBImSrfqejS5aDLL-PG-Z1TL7NnVtXBvBq_Z9nPL5c_Lpazq-uvq4vzq5kuBI4zy4RgVtuKgwBlMC5tuaBCWAEUQFmGSwLECgOaIg2CwkJUpOBYU2uFNeQse3vw3dU-yDErQWIqECBWcJqI1YGovNrKXeca1d1Jr5z8e-C7tVRddLo2kgmokAJWMWao0KREXPMSgJe0KLAavD6P0fqyMZVOr-5UPTGd3rRuI9d-L_lCIA44GXwYDTp_25sQZeOCNnWtWuP7w38LBpRDQt_9gz7-upFK1TMylcSnuHowlecFwxjzBRvCzh-h0qpM43RqIevS-UTwcSJITDS_41r1IcjV92__z17fTNn3R-zGqDpugq_7odnCFKQHUHc-hM7YhyQjkMME3GdDDhMgxwlIsjfHBXoQ3bc8-QN3KgAF</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2491015674</pqid></control><display><type>article</type><title>Human cytomegalovirus infection among treatment-naive HIV-1 infected patients in Ethiopia</title><source>DOAJ Directory of Open Access Journals</source><source>PLoS - Public Library of Sciencem (Open Access)</source><source>Free E-Journal (出版社公開部分のみ）</source><source>PubMed</source><source>Free Full-Text Journals in Chemistry</source><creator>Kiros, Mulugeta ; Geteneh, Alene ; Andualem, Henok ; Alemu, Derbie ; Tesfaye, Abebech ; Tefera, Dessalegne Abeje ; Mihret, Adane ; Alemayehu, Dawit Hailu ; Mulu, Andargachew</creator><contributor>O’Connor, Christine M.</contributor><creatorcontrib>Kiros, Mulugeta ; Geteneh, Alene ; Andualem, Henok ; Alemu, Derbie ; Tesfaye, Abebech ; Tefera, Dessalegne Abeje ; Mihret, Adane ; Alemayehu, Dawit Hailu ; Mulu, Andargachew ; O’Connor, Christine M.</creatorcontrib><description>Subclinical human cytomegalovirus (HCMV) replication is associated with immune dysfunction in immuno-suppressed antiretroviral therapy (ART) naive HIV infected individuals. No data is documented in Ethiopia so far concerning HCMV co-infection among HIV infected individuals. Hence, this study was aimed at generating data regarding the prevalence of active HCMV infection among treatment-naive HIV-infected individuals from Ethiopia. For this purpose, we enrolled 97 treatment-naive HIV infected study subjects in Addis Ababa from June to December 2018. ELISA and conventional PCR were performed consecutively to detect HCMV specific IgM antibody and HCMV DNA respectively. Of the 97 study subjects, 12 (12.4%) were positive for anti-CMV IgM antibodies but were not confirmed by PCR. With regard to the PCR positivity, 4/97 (4.1%) samples were positive for HCMV DNA. No statically significant associations were found between the dependent and independent variables. The presence of HCMV DNA in the current study highlights the need for a routine laboratory diagnosis for preventing HCMV disease among HIV-infected individuals early. Besides, the use of anti-CMV therapy for these CMV viremic individuals is also recommended as this can reduce the burden of CMV complications and consecutively prolonging the life of HIV infected individuals.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0247264</identifier><identifier>PMID: 33600457</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Antibodies ; Biology and Life Sciences ; Cytomegalovirus ; Cytomegalovirus infections ; Deoxyribonucleic acid ; Developing countries ; Diagnosis ; DNA ; Editing ; Females ; Health sciences ; HIV ; HIV patients ; Human immunodeficiency virus ; Immune system ; Immunoglobulin G ; Immunoglobulin M ; Infections ; LDCs ; Medical laboratories ; Medicine and Health Sciences ; Methodology ; Plasma ; Research and Analysis Methods ; Risk factors ; Secondary infection ; Serology ; Sociodemographics ; Statistics ; Thermal cycling ; Viruses</subject><ispartof>PloS one, 2021-02, Vol.16 (2), p.e0247264-e0247264</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Kiros et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Kiros et al 2021 Kiros et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-f5995fcfd7090ae22bfb8499f90400af52b303f9e0c41c094089d3672c4ff9fe3</citedby><cites>FETCH-LOGICAL-c692t-f5995fcfd7090ae22bfb8499f90400af52b303f9e0c41c094089d3672c4ff9fe3</cites><orcidid>0000-0001-6883-9548 ; 0000-0002-7909-7719 ; 0000-0002-7153-4849</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891702/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891702/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33600457$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>O’Connor, Christine M.</contributor><creatorcontrib>Kiros, Mulugeta</creatorcontrib><creatorcontrib>Geteneh, Alene</creatorcontrib><creatorcontrib>Andualem, Henok</creatorcontrib><creatorcontrib>Alemu, Derbie</creatorcontrib><creatorcontrib>Tesfaye, Abebech</creatorcontrib><creatorcontrib>Tefera, Dessalegne Abeje</creatorcontrib><creatorcontrib>Mihret, Adane</creatorcontrib><creatorcontrib>Alemayehu, Dawit Hailu</creatorcontrib><creatorcontrib>Mulu, Andargachew</creatorcontrib><title>Human cytomegalovirus infection among treatment-naive HIV-1 infected patients in Ethiopia</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Subclinical human cytomegalovirus (HCMV) replication is associated with immune dysfunction in immuno-suppressed antiretroviral therapy (ART) naive HIV infected individuals. No data is documented in Ethiopia so far concerning HCMV co-infection among HIV infected individuals. Hence, this study was aimed at generating data regarding the prevalence of active HCMV infection among treatment-naive HIV-infected individuals from Ethiopia. For this purpose, we enrolled 97 treatment-naive HIV infected study subjects in Addis Ababa from June to December 2018. ELISA and conventional PCR were performed consecutively to detect HCMV specific IgM antibody and HCMV DNA respectively. Of the 97 study subjects, 12 (12.4%) were positive for anti-CMV IgM antibodies but were not confirmed by PCR. With regard to the PCR positivity, 4/97 (4.1%) samples were positive for HCMV DNA. No statically significant associations were found between the dependent and independent variables. The presence of HCMV DNA in the current study highlights the need for a routine laboratory diagnosis for preventing HCMV disease among HIV-infected individuals early. Besides, the use of anti-CMV therapy for these CMV viremic individuals is also recommended as this can reduce the burden of CMV complications and consecutively prolonging the life of HIV infected individuals.</description><subject>Antibodies</subject><subject>Biology and Life Sciences</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus infections</subject><subject>Deoxyribonucleic acid</subject><subject>Developing countries</subject><subject>Diagnosis</subject><subject>DNA</subject><subject>Editing</subject><subject>Females</subject><subject>Health sciences</subject><subject>HIV</subject><subject>HIV patients</subject><subject>Human immunodeficiency virus</subject><subject>Immune system</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin M</subject><subject>Infections</subject><subject>LDCs</subject><subject>Medical laboratories</subject><subject>Medicine and Health Sciences</subject><subject>Methodology</subject><subject>Plasma</subject><subject>Research and Analysis Methods</subject><subject>Risk factors</subject><subject>Secondary infection</subject><subject>Serology</subject><subject>Sociodemographics</subject><subject>Statistics</subject><subject>Thermal cycling</subject><subject>Viruses</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11r2zAUhs3YWLtu_2BshsHYLpIdfVnRzaCUbgkUCvso7ErIspQo2FZqyWH995MXt8SjF0MXFtLzvsc6H1n2GsEcEY4-bX3ftaqe73xr5oApxwV9kp0iQfCswECeHu1PshchbAEYWRTF8-yEkAKAMn6a_Vr2jWpzfRd9Y9aq9nvX9SF3rTU6Ot_mqvHtOo-dUbExbZy1yu1NvlzdzNBImSrfqejS5aDLL-PG-Z1TL7NnVtXBvBq_Z9nPL5c_Lpazq-uvq4vzq5kuBI4zy4RgVtuKgwBlMC5tuaBCWAEUQFmGSwLECgOaIg2CwkJUpOBYU2uFNeQse3vw3dU-yDErQWIqECBWcJqI1YGovNrKXeca1d1Jr5z8e-C7tVRddLo2kgmokAJWMWao0KREXPMSgJe0KLAavD6P0fqyMZVOr-5UPTGd3rRuI9d-L_lCIA44GXwYDTp_25sQZeOCNnWtWuP7w38LBpRDQt_9gz7-upFK1TMylcSnuHowlecFwxjzBRvCzh-h0qpM43RqIevS-UTwcSJITDS_41r1IcjV92__z17fTNn3R-zGqDpugq_7odnCFKQHUHc-hM7YhyQjkMME3GdDDhMgxwlIsjfHBXoQ3bc8-QN3KgAF</recordid><startdate>20210218</startdate><enddate>20210218</enddate><creator>Kiros, Mulugeta</creator><creator>Geteneh, Alene</creator><creator>Andualem, Henok</creator><creator>Alemu, Derbie</creator><creator>Tesfaye, Abebech</creator><creator>Tefera, Dessalegne Abeje</creator><creator>Mihret, Adane</creator><creator>Alemayehu, Dawit Hailu</creator><creator>Mulu, Andargachew</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6883-9548</orcidid><orcidid>https://orcid.org/0000-0002-7909-7719</orcidid><orcidid>https://orcid.org/0000-0002-7153-4849</orcidid></search><sort><creationdate>20210218</creationdate><title>Human cytomegalovirus infection among treatment-naive HIV-1 infected patients in Ethiopia</title><author>Kiros, Mulugeta ; Geteneh, Alene ; Andualem, Henok ; Alemu, Derbie ; Tesfaye, Abebech ; Tefera, Dessalegne Abeje ; Mihret, Adane ; Alemayehu, Dawit Hailu ; Mulu, Andargachew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-f5995fcfd7090ae22bfb8499f90400af52b303f9e0c41c094089d3672c4ff9fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antibodies</topic><topic>Biology and Life Sciences</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus infections</topic><topic>Deoxyribonucleic acid</topic><topic>Developing countries</topic><topic>Diagnosis</topic><topic>DNA</topic><topic>Editing</topic><topic>Females</topic><topic>Health sciences</topic><topic>HIV</topic><topic>HIV patients</topic><topic>Human immunodeficiency virus</topic><topic>Immune system</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin M</topic><topic>Infections</topic><topic>LDCs</topic><topic>Medical laboratories</topic><topic>Medicine and Health Sciences</topic><topic>Methodology</topic><topic>Plasma</topic><topic>Research and Analysis Methods</topic><topic>Risk factors</topic><topic>Secondary infection</topic><topic>Serology</topic><topic>Sociodemographics</topic><topic>Statistics</topic><topic>Thermal cycling</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kiros, Mulugeta</creatorcontrib><creatorcontrib>Geteneh, Alene</creatorcontrib><creatorcontrib>Andualem, Henok</creatorcontrib><creatorcontrib>Alemu, Derbie</creatorcontrib><creatorcontrib>Tesfaye, Abebech</creatorcontrib><creatorcontrib>Tefera, Dessalegne Abeje</creatorcontrib><creatorcontrib>Mihret, Adane</creatorcontrib><creatorcontrib>Alemayehu, Dawit Hailu</creatorcontrib><creatorcontrib>Mulu, Andargachew</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints Resource Center</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Database (1962 - current)</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>https://resources.nclive.org/materials</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials science collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kiros, Mulugeta</au><au>Geteneh, Alene</au><au>Andualem, Henok</au><au>Alemu, Derbie</au><au>Tesfaye, Abebech</au><au>Tefera, Dessalegne Abeje</au><au>Mihret, Adane</au><au>Alemayehu, Dawit Hailu</au><au>Mulu, Andargachew</au><au>O’Connor, Christine M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human cytomegalovirus infection among treatment-naive HIV-1 infected patients in Ethiopia</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-02-18</date><risdate>2021</risdate><volume>16</volume><issue>2</issue><spage>e0247264</spage><epage>e0247264</epage><pages>e0247264-e0247264</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Subclinical human cytomegalovirus (HCMV) replication is associated with immune dysfunction in immuno-suppressed antiretroviral therapy (ART) naive HIV infected individuals. No data is documented in Ethiopia so far concerning HCMV co-infection among HIV infected individuals. Hence, this study was aimed at generating data regarding the prevalence of active HCMV infection among treatment-naive HIV-infected individuals from Ethiopia. For this purpose, we enrolled 97 treatment-naive HIV infected study subjects in Addis Ababa from June to December 2018. ELISA and conventional PCR were performed consecutively to detect HCMV specific IgM antibody and HCMV DNA respectively. Of the 97 study subjects, 12 (12.4%) were positive for anti-CMV IgM antibodies but were not confirmed by PCR. With regard to the PCR positivity, 4/97 (4.1%) samples were positive for HCMV DNA. No statically significant associations were found between the dependent and independent variables. The presence of HCMV DNA in the current study highlights the need for a routine laboratory diagnosis for preventing HCMV disease among HIV-infected individuals early. Besides, the use of anti-CMV therapy for these CMV viremic individuals is also recommended as this can reduce the burden of CMV complications and consecutively prolonging the life of HIV infected individuals.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33600457</pmid><doi>10.1371/journal.pone.0247264</doi><tpages>e0247264</tpages><orcidid>https://orcid.org/0000-0001-6883-9548</orcidid><orcidid>https://orcid.org/0000-0002-7909-7719</orcidid><orcidid>https://orcid.org/0000-0002-7153-4849</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-02, Vol.16 (2), p.e0247264-e0247264 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2491015674 |
| source | DOAJ Directory of Open Access Journals; PLoS - Public Library of Sciencem (Open Access); Free E-Journal (出版社公開部分のみ）; PubMed; Free Full-Text Journals in Chemistry |
| subjects | Antibodies Biology and Life Sciences Cytomegalovirus Cytomegalovirus infections Deoxyribonucleic acid Developing countries Diagnosis DNA Editing Females Health sciences HIV HIV patients Human immunodeficiency virus Immune system Immunoglobulin G Immunoglobulin M Infections LDCs Medical laboratories Medicine and Health Sciences Methodology Plasma Research and Analysis Methods Risk factors Secondary infection Serology Sociodemographics Statistics Thermal cycling Viruses |
| title | Human cytomegalovirus infection among treatment-naive HIV-1 infected patients in Ethiopia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T06%3A29%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Human%20cytomegalovirus%20infection%20among%20treatment-naive%20HIV-1%20infected%20patients%20in%20Ethiopia&rft.jtitle=PloS%20one&rft.au=Kiros,%20Mulugeta&rft.date=2021-02-18&rft.volume=16&rft.issue=2&rft.spage=e0247264&rft.epage=e0247264&rft.pages=e0247264-e0247264&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0247264&rft_dat=%3Cgale_plos_%3EA652227852%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2491015674&rft_id=info:pmid/33600457&rft_galeid=A652227852&rft_doaj_id=oai_doaj_org_article_590d1a05d55e49c3b17c7b007b4662a4&rfr_iscdi=true |