Serum symmetric dimethylarginine shows a relatively consistent long-term concentration in healthy dogs with a significant effect of increased body fat percentage
Symmetric dimethylarginine (SDMA) is a promising renal marker that correlates well with the glomerular filtration rate and could allow earlier detection of impaired renal function. The main objectives of this study were to assess the long-term variability of SDMA in healthy dogs and examine the infl...
Gespeichert in:
| Veröffentlicht in: | PloS one 2021-02, Vol.16 (2), p.e0247049-e0247049 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0247049 |
|---|---|
| container_issue | 2 |
| container_start_page | e0247049 |
| container_title | PloS one |
| container_volume | 16 |
| creator | Hillaert, Amber Liu, Daisy J X Daminet, Sylvie Broeckx, Bart J G Stock, Emmelie Paepe, Dominique Hesta, Myriam Vanderperren, Katrien |
| description | Symmetric dimethylarginine (SDMA) is a promising renal marker that correlates well with the glomerular filtration rate and could allow earlier detection of impaired renal function. The main objectives of this study were to assess the long-term variability of SDMA in healthy dogs and examine the influence of an increased body fat percentage on the level of SDMA. Sixteen lean Beagles were randomly assigned to the control group or weight-change group in age- and gender-matched pairs. The energy intake of the control group (n = 8) was strictly regulated to maintain an ideal body weight for 83 weeks, while the weight-change group (n = 8) was fed to induce weight gain (week 0-47), to maintain stable excessive body weight (week 47-56) and to lose weight (week 56-83), consecutively. At 8 specified time points, the body condition score, body composition, glomerular filtration rate, serum concentration of SDMA and creatinine were analyzed. In the control group, the within-subject coefficient of variation, between-subject coefficient of variation, reference change value (type I error = 5%) and index of individuality were 0.16, 0.22, 0.43 and 0.73, respectively. The control group and weight-change group did not differ significantly in SDMA concentration. SDMA showed a significant negative association (coefficient = -0.07) with body fat percentage (p |
| doi_str_mv | 10.1371/journal.pone.0247049 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2490578130</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A652074699</galeid><doaj_id>oai_doaj_org_article_532ddefac7374bb0ad652d5a108dad42</doaj_id><sourcerecordid>A652074699</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-becc3eb4bd4e1b2e17b25339679ced5bfad2035141cd6c616f6d4e73018531ab3</originalsourceid><addsrcrecordid>eNqNk11rFDEUhgdRbF39B6IBQfRi12QynzdCKX4sFApWvQ2Z5MxslkyyJpnW_Tn-UzPdadmRXkguEk6e901yck6SvCR4RWhJPmzt4AzXq501sMJpVuKsfpSckpqmyyLF9PHR-iR55v0W45xWRfE0OaE0r4uU4tPkzxW4oUd-3_cQnBJIqrjY7DV3nTLKAPIbe-MRRw40D-oa9B4Ja7zyAUxA2ppuGcD1Y1DEiIuQNUgZtAGuoxOStvPoRoVNNPGqM6pVgkcptC2IgGwbYeGAe5CosXKPWh7QDtzoxjt4njxpufbwYpoXyY_Pn76ff11eXH5Zn59dLEVRp2HZgBAUmqyRGZAmBVI2aU5pXZS1AJk3LZcxETnJiJCFKEjRFpEsKSZVTglv6CJ5ffDdaevZlF3P0qzGeVkRiiOxPhDS8i3bOdVzt2eWK3YbsK5j3AUlNLCcplJCy0VJy6xpMJdFnsqcE1xJLrM0en2cThuaHuQhc3pmOt8xasM6e83KqqrGL10k7yYDZ38N4APrlRegNTdgh9t7E1ySLKsi-uYf9OHXTVTH4wOUaW08V4ym7CxeHpdZUdeRWj1AxSGhV7EEoFUxPhO8nwkiE-B36PjgPVtffft_9vLnnH17xB5qzVs9jNXn52B2AIWz3jto75NMMBs76S4bbOwkNnVSlL06_qB70V3r0L8Ypx3G</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2490578130</pqid></control><display><type>article</type><title>Serum symmetric dimethylarginine shows a relatively consistent long-term concentration in healthy dogs with a significant effect of increased body fat percentage</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Hillaert, Amber ; Liu, Daisy J X ; Daminet, Sylvie ; Broeckx, Bart J G ; Stock, Emmelie ; Paepe, Dominique ; Hesta, Myriam ; Vanderperren, Katrien</creator><contributor>Clegg, Simon</contributor><creatorcontrib>Hillaert, Amber ; Liu, Daisy J X ; Daminet, Sylvie ; Broeckx, Bart J G ; Stock, Emmelie ; Paepe, Dominique ; Hesta, Myriam ; Vanderperren, Katrien ; Clegg, Simon</creatorcontrib><description>Symmetric dimethylarginine (SDMA) is a promising renal marker that correlates well with the glomerular filtration rate and could allow earlier detection of impaired renal function. The main objectives of this study were to assess the long-term variability of SDMA in healthy dogs and examine the influence of an increased body fat percentage on the level of SDMA. Sixteen lean Beagles were randomly assigned to the control group or weight-change group in age- and gender-matched pairs. The energy intake of the control group (n = 8) was strictly regulated to maintain an ideal body weight for 83 weeks, while the weight-change group (n = 8) was fed to induce weight gain (week 0-47), to maintain stable excessive body weight (week 47-56) and to lose weight (week 56-83), consecutively. At 8 specified time points, the body condition score, body composition, glomerular filtration rate, serum concentration of SDMA and creatinine were analyzed. In the control group, the within-subject coefficient of variation, between-subject coefficient of variation, reference change value (type I error = 5%) and index of individuality were 0.16, 0.22, 0.43 and 0.73, respectively. The control group and weight-change group did not differ significantly in SDMA concentration. SDMA showed a significant negative association (coefficient = -0.07) with body fat percentage (p<0.01) in the weight-change group and a significant positive association (coefficient = 7.79) with serum creatinine (p<0.01) in the entire study population. In conclusion, SDMA concentration has high long-term stability in healthy adult dogs. For the evaluation of SDMA concentrations, subject-specific reference values are preferred over a population-based reference value seen their higher sensitivity. Moreover, an increased body fat percentage does seem to affect the serum SDMA concentration of otherwise healthy dogs, but its clinical relevance has to be clarified in further research.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0247049</identifier><identifier>PMID: 33596230</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adipose tissues ; Animals ; Biological markers ; Biology and Life Sciences ; Body composition ; Body fat ; Body weight ; Chronic illnesses ; Diseases ; Dogs ; Domestic animals ; Editing ; Funding ; Genetics ; Glomerular filtration rate ; Health aspects ; Kidney diseases ; Measurement ; Medical imaging ; Medicine ; Medicine and Health Sciences ; Methodology ; Nutrition ; Nutrition research ; Obesity ; Orthopedics ; Renal function ; Reviews ; Veterinary medicine</subject><ispartof>PloS one, 2021-02, Vol.16 (2), p.e0247049-e0247049</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Hillaert et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Hillaert et al 2021 Hillaert et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-becc3eb4bd4e1b2e17b25339679ced5bfad2035141cd6c616f6d4e73018531ab3</citedby><cites>FETCH-LOGICAL-c692t-becc3eb4bd4e1b2e17b25339679ced5bfad2035141cd6c616f6d4e73018531ab3</cites><orcidid>0000-0003-3262-8495</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888620/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888620/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33596230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Clegg, Simon</contributor><creatorcontrib>Hillaert, Amber</creatorcontrib><creatorcontrib>Liu, Daisy J X</creatorcontrib><creatorcontrib>Daminet, Sylvie</creatorcontrib><creatorcontrib>Broeckx, Bart J G</creatorcontrib><creatorcontrib>Stock, Emmelie</creatorcontrib><creatorcontrib>Paepe, Dominique</creatorcontrib><creatorcontrib>Hesta, Myriam</creatorcontrib><creatorcontrib>Vanderperren, Katrien</creatorcontrib><title>Serum symmetric dimethylarginine shows a relatively consistent long-term concentration in healthy dogs with a significant effect of increased body fat percentage</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Symmetric dimethylarginine (SDMA) is a promising renal marker that correlates well with the glomerular filtration rate and could allow earlier detection of impaired renal function. The main objectives of this study were to assess the long-term variability of SDMA in healthy dogs and examine the influence of an increased body fat percentage on the level of SDMA. Sixteen lean Beagles were randomly assigned to the control group or weight-change group in age- and gender-matched pairs. The energy intake of the control group (n = 8) was strictly regulated to maintain an ideal body weight for 83 weeks, while the weight-change group (n = 8) was fed to induce weight gain (week 0-47), to maintain stable excessive body weight (week 47-56) and to lose weight (week 56-83), consecutively. At 8 specified time points, the body condition score, body composition, glomerular filtration rate, serum concentration of SDMA and creatinine were analyzed. In the control group, the within-subject coefficient of variation, between-subject coefficient of variation, reference change value (type I error = 5%) and index of individuality were 0.16, 0.22, 0.43 and 0.73, respectively. The control group and weight-change group did not differ significantly in SDMA concentration. SDMA showed a significant negative association (coefficient = -0.07) with body fat percentage (p<0.01) in the weight-change group and a significant positive association (coefficient = 7.79) with serum creatinine (p<0.01) in the entire study population. In conclusion, SDMA concentration has high long-term stability in healthy adult dogs. For the evaluation of SDMA concentrations, subject-specific reference values are preferred over a population-based reference value seen their higher sensitivity. Moreover, an increased body fat percentage does seem to affect the serum SDMA concentration of otherwise healthy dogs, but its clinical relevance has to be clarified in further research.</description><subject>Adipose tissues</subject><subject>Animals</subject><subject>Biological markers</subject><subject>Biology and Life Sciences</subject><subject>Body composition</subject><subject>Body fat</subject><subject>Body weight</subject><subject>Chronic illnesses</subject><subject>Diseases</subject><subject>Dogs</subject><subject>Domestic animals</subject><subject>Editing</subject><subject>Funding</subject><subject>Genetics</subject><subject>Glomerular filtration rate</subject><subject>Health aspects</subject><subject>Kidney diseases</subject><subject>Measurement</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Methodology</subject><subject>Nutrition</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>Orthopedics</subject><subject>Renal function</subject><subject>Reviews</subject><subject>Veterinary medicine</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11rFDEUhgdRbF39B6IBQfRi12QynzdCKX4sFApWvQ2Z5MxslkyyJpnW_Tn-UzPdadmRXkguEk6e901yck6SvCR4RWhJPmzt4AzXq501sMJpVuKsfpSckpqmyyLF9PHR-iR55v0W45xWRfE0OaE0r4uU4tPkzxW4oUd-3_cQnBJIqrjY7DV3nTLKAPIbe-MRRw40D-oa9B4Ja7zyAUxA2ppuGcD1Y1DEiIuQNUgZtAGuoxOStvPoRoVNNPGqM6pVgkcptC2IgGwbYeGAe5CosXKPWh7QDtzoxjt4njxpufbwYpoXyY_Pn76ff11eXH5Zn59dLEVRp2HZgBAUmqyRGZAmBVI2aU5pXZS1AJk3LZcxETnJiJCFKEjRFpEsKSZVTglv6CJ5ffDdaevZlF3P0qzGeVkRiiOxPhDS8i3bOdVzt2eWK3YbsK5j3AUlNLCcplJCy0VJy6xpMJdFnsqcE1xJLrM0en2cThuaHuQhc3pmOt8xasM6e83KqqrGL10k7yYDZ38N4APrlRegNTdgh9t7E1ySLKsi-uYf9OHXTVTH4wOUaW08V4ym7CxeHpdZUdeRWj1AxSGhV7EEoFUxPhO8nwkiE-B36PjgPVtffft_9vLnnH17xB5qzVs9jNXn52B2AIWz3jto75NMMBs76S4bbOwkNnVSlL06_qB70V3r0L8Ypx3G</recordid><startdate>20210217</startdate><enddate>20210217</enddate><creator>Hillaert, Amber</creator><creator>Liu, Daisy J X</creator><creator>Daminet, Sylvie</creator><creator>Broeckx, Bart J G</creator><creator>Stock, Emmelie</creator><creator>Paepe, Dominique</creator><creator>Hesta, Myriam</creator><creator>Vanderperren, Katrien</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-3262-8495</orcidid></search><sort><creationdate>20210217</creationdate><title>Serum symmetric dimethylarginine shows a relatively consistent long-term concentration in healthy dogs with a significant effect of increased body fat percentage</title><author>Hillaert, Amber ; Liu, Daisy J X ; Daminet, Sylvie ; Broeckx, Bart J G ; Stock, Emmelie ; Paepe, Dominique ; Hesta, Myriam ; Vanderperren, Katrien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-becc3eb4bd4e1b2e17b25339679ced5bfad2035141cd6c616f6d4e73018531ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adipose tissues</topic><topic>Animals</topic><topic>Biological markers</topic><topic>Biology and Life Sciences</topic><topic>Body composition</topic><topic>Body fat</topic><topic>Body weight</topic><topic>Chronic illnesses</topic><topic>Diseases</topic><topic>Dogs</topic><topic>Domestic animals</topic><topic>Editing</topic><topic>Funding</topic><topic>Genetics</topic><topic>Glomerular filtration rate</topic><topic>Health aspects</topic><topic>Kidney diseases</topic><topic>Measurement</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Methodology</topic><topic>Nutrition</topic><topic>Nutrition research</topic><topic>Obesity</topic><topic>Orthopedics</topic><topic>Renal function</topic><topic>Reviews</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hillaert, Amber</creatorcontrib><creatorcontrib>Liu, Daisy J X</creatorcontrib><creatorcontrib>Daminet, Sylvie</creatorcontrib><creatorcontrib>Broeckx, Bart J G</creatorcontrib><creatorcontrib>Stock, Emmelie</creatorcontrib><creatorcontrib>Paepe, Dominique</creatorcontrib><creatorcontrib>Hesta, Myriam</creatorcontrib><creatorcontrib>Vanderperren, Katrien</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hillaert, Amber</au><au>Liu, Daisy J X</au><au>Daminet, Sylvie</au><au>Broeckx, Bart J G</au><au>Stock, Emmelie</au><au>Paepe, Dominique</au><au>Hesta, Myriam</au><au>Vanderperren, Katrien</au><au>Clegg, Simon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum symmetric dimethylarginine shows a relatively consistent long-term concentration in healthy dogs with a significant effect of increased body fat percentage</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-02-17</date><risdate>2021</risdate><volume>16</volume><issue>2</issue><spage>e0247049</spage><epage>e0247049</epage><pages>e0247049-e0247049</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Symmetric dimethylarginine (SDMA) is a promising renal marker that correlates well with the glomerular filtration rate and could allow earlier detection of impaired renal function. The main objectives of this study were to assess the long-term variability of SDMA in healthy dogs and examine the influence of an increased body fat percentage on the level of SDMA. Sixteen lean Beagles were randomly assigned to the control group or weight-change group in age- and gender-matched pairs. The energy intake of the control group (n = 8) was strictly regulated to maintain an ideal body weight for 83 weeks, while the weight-change group (n = 8) was fed to induce weight gain (week 0-47), to maintain stable excessive body weight (week 47-56) and to lose weight (week 56-83), consecutively. At 8 specified time points, the body condition score, body composition, glomerular filtration rate, serum concentration of SDMA and creatinine were analyzed. In the control group, the within-subject coefficient of variation, between-subject coefficient of variation, reference change value (type I error = 5%) and index of individuality were 0.16, 0.22, 0.43 and 0.73, respectively. The control group and weight-change group did not differ significantly in SDMA concentration. SDMA showed a significant negative association (coefficient = -0.07) with body fat percentage (p<0.01) in the weight-change group and a significant positive association (coefficient = 7.79) with serum creatinine (p<0.01) in the entire study population. In conclusion, SDMA concentration has high long-term stability in healthy adult dogs. For the evaluation of SDMA concentrations, subject-specific reference values are preferred over a population-based reference value seen their higher sensitivity. Moreover, an increased body fat percentage does seem to affect the serum SDMA concentration of otherwise healthy dogs, but its clinical relevance has to be clarified in further research.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33596230</pmid><doi>10.1371/journal.pone.0247049</doi><tpages>e0247049</tpages><orcidid>https://orcid.org/0000-0003-3262-8495</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-02, Vol.16 (2), p.e0247049-e0247049 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2490578130 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adipose tissues Animals Biological markers Biology and Life Sciences Body composition Body fat Body weight Chronic illnesses Diseases Dogs Domestic animals Editing Funding Genetics Glomerular filtration rate Health aspects Kidney diseases Measurement Medical imaging Medicine Medicine and Health Sciences Methodology Nutrition Nutrition research Obesity Orthopedics Renal function Reviews Veterinary medicine |
| title | Serum symmetric dimethylarginine shows a relatively consistent long-term concentration in healthy dogs with a significant effect of increased body fat percentage |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T02%3A02%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%20symmetric%20dimethylarginine%20shows%20a%20relatively%20consistent%20long-term%20concentration%20in%20healthy%20dogs%20with%20a%20significant%20effect%20of%20increased%20body%20fat%20percentage&rft.jtitle=PloS%20one&rft.au=Hillaert,%20Amber&rft.date=2021-02-17&rft.volume=16&rft.issue=2&rft.spage=e0247049&rft.epage=e0247049&rft.pages=e0247049-e0247049&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0247049&rft_dat=%3Cgale_plos_%3EA652074699%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2490578130&rft_id=info:pmid/33596230&rft_galeid=A652074699&rft_doaj_id=oai_doaj_org_article_532ddefac7374bb0ad652d5a108dad42&rfr_iscdi=true |