Identification of 3' UTR motifs required for mRNA localization to myelin sheaths in vivo

Myelin is a specialized membrane produced by oligodendrocytes that insulates and supports axons. Oligodendrocytes extend numerous cellular processes, as projections of the plasma membrane, and simultaneously wrap multiple layers of myelin membrane around target axons. Notably, myelin sheaths origina...

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Veröffentlicht in:	PLoS biology 2021-01, Vol.19 (1), p.e3001053-e3001053
Hauptverfasser:	Yergert, Katie M, Doll, Caleb A, O'Rouke, Rebecca, Hines, Jacob H, Appel, Bruce
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Amino acid sequence Binding sites Biology and life sciences Coat protein Deoxyribonucleic acid DNA Fluorescence Fluorescence in situ hybridization Gene expression Genetic aspects Genetic translation Hindbrain Hybridization Identification and classification Investigations Larvae Localization Messenger RNA Myelin Myelin sheath Oligodendrocyte-myelin glycoprotein Oligodendrocytes Physiological aspects Plasmids Proteins Regulatory sequences Research and Analysis Methods Sheaths Sox10 protein Spatial distribution Zebrafish
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