Extensive proteomic and transcriptomic changes quench the TCR/CD3 activation signal of latently HIV-1 infected T cells

The biomolecular mechanisms controlling latent HIV-1 infection, despite their importance for the development of a cure for HIV-1 infection, are only partially understood. For example, ex vivo studies have recently shown that T cell activation only triggered HIV-1 reactivation in a fraction of the la...

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Veröffentlicht in:	PLoS pathogens 2021-01, Vol.17 (1), p.e1008748-e1008748
Hauptverfasser:	Carlin, Eric, Greer, Braxton, Lowman, Kelsey, Duverger, Alexandra, Wagner, Frederic, Moylan, David, Dalecki, Alexander, Samuel, Shekwonya, Perez, Mildred, Sabbaj, Steffanie, Kutsch, Olaf
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens Biology and Life Sciences Biotechnology Care and treatment CD28 antigen CD3 antigen CD3 Complex - immunology CD3 Complex - metabolism CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - virology Cell activation Cell lines Cell receptors Cellular proteins Chromatin Computer and Information Sciences Development and progression Experiments Gene expression Gene Expression Regulation, Viral Gene Regulatory Networks Genetic aspects Genotype & phenotype Health aspects HIV HIV infection HIV Infections - genetics HIV Infections - immunology HIV Infections - metabolism HIV Infections - virology HIV-1 - physiology Human immunodeficiency virus Humans Immunology Infections Ionomycin Latent infection Lymphocyte Activation Lymphocytes Lymphocytes T Medicine and Health Sciences Phenotypes Population Proteome Proteomes Proteomics Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Signal Transduction Stimulation T cell receptors T cells T-cell receptor Transcriptome Transcriptomes Virus Activation Virus Latency Virus Replication
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