Assessing the risk of ketoacidosis due to sodium-glucose cotransporter (SGLT)-2 inhibitors in patients with type 1 diabetes: A meta-analysis and meta-regression

Sodium-glucose cotransporter-2 (SGLT2) inhibitors (SGLT2i) showed benefits in type 1 diabetes mellitus (T1DM), but the risk of diabetic ketoacidosis (DKA) limits their use. Ability to predict DKA risk and therapeutic responses would enable appropriate patient selection for SGLT2i. We conducted a met...

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Veröffentlicht in:	PLoS medicine 2020-12, Vol.17 (12), p.e1003461
Hauptverfasser:	Musso, Giovanni, Sircana, Antonio, Saba, Francesca, Cassader, Maurizio, Gambino, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bias Biology and Life Sciences Body mass index Care and treatment Comparative analysis Complications and side effects Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - diagnosis Diabetes Mellitus, Type 1 - drug therapy Diabetic acidosis Diabetic Ketoacidosis - chemically induced Diabetic Ketoacidosis - diagnosis Diabetics Diagnosis Distribution Dosage and administration Drug development Drug dosages Epidermal growth factor receptors Eye disorders Fasting Female Genital tract Glucose Handbooks Hemoglobin Humans Hypoglycemia Hypoglycemic agents Insulin Insulin resistance Intervention Ketoacidosis Laboratory testing Male Medicine and Health Sciences Meta-analysis Middle Aged Na+/glucose cotransporter Optimization Patients Physical Sciences Randomized Controlled Trials as Topic Regulatory agencies Renal function Research and Analysis Methods Risk Assessment Risk Factors Sodium-Glucose Transporter 2 Inhibitors - adverse effects Treatment Outcome Type 1 diabetes Urinary tract Young Adult
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