Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes

Infections with Gram-negative bacteria form an increasing risk for human health due to antibiotic resistance. Our immune system contains various antimicrobial proteins that can degrade the bacterial cell envelope. However, many of these proteins do not function on Gram-negative bacteria, because the...

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Veröffentlicht in:	PLoS pathogens 2021-01, Vol.17 (1), p.e1009227-e1009227
Hauptverfasser:	Heesterbeek, Dani A C, Muts, Remy M, van Hensbergen, Vincent P, de Saint Aulaire, Pieter, Wennekes, Tom, Bardoel, Bart W, van Sorge, Nina M, Rooijakkers, Suzan H M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Anti-Infective Agents - pharmacology Antibiotic resistance Antibiotics Antiinfectives and antibacterials Antimicrobial agents Antimicrobial peptides Apoptosis Bacteria Bacterial Outer Membrane - drug effects Biodegradation Biology and Life Sciences Care and treatment Cell morphology Cell size Cell Wall - drug effects Cell walls Complement Activation Complement Membrane Attack Complex - metabolism Confocal microscopy Cytology Development and progression Drug resistance E coli Escherichia coli Escherichia coli - drug effects Escherichia coli - immunology Flow Cytometry Genetic aspects Gram-negative bacteria Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - immunology Gram-negative bacterial infections Gram-positive bacteria Group II Phospholipases A2 - metabolism Health aspects Host-bacteria relationships Humans Immune response Immune system Immunology Infections Lysozyme Medicine and Health Sciences Membrane attack complex Membranes Microbiological research Microscopy Microscopy, Confocal Morphology Muramidase - metabolism Neutrophils Neutrophils - microbiology Peptidoglycans Phagocytes Phagocytes - microbiology Proteins Pseudomonas aeruginosa Research and Analysis Methods
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