Early dynamic changes in circulating tumor cells and prognostic relevance following interventional radiological treatments in patients with hepatocellular carcinoma
The aim of this study was to investigate the dynamic changes of circulating tumor cells (CTCs) in patients with hepatocellular carcinoma (HCC) before and immediately after conducting a microwave ablation (MWA) and conventional transarterial chemoembolization (C-TACE). Additionally, the CTCs short-te...
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| creator | Vogl, Thomas J Riegelbauer, Linda J Oppermann, Elsie Kostantin, Michel Ackermann, Hanns Trzmiel, Annette Stein, Stefan Eichler, Katrin Zharov, Vladimir P Roy, Dhruvajyoti Schnitzbauer, Andreas A Strücker, Benjamin Pascher, Andreas Bechstein, Wolf O Juratli, Mazen A |
| description | The aim of this study was to investigate the dynamic changes of circulating tumor cells (CTCs) in patients with hepatocellular carcinoma (HCC) before and immediately after conducting a microwave ablation (MWA) and conventional transarterial chemoembolization (C-TACE). Additionally, the CTCs short-term dynamics were compared with the clinical course of the HCC-patients. Blood samples from 17 patients with HCC who underwent MWA (n = 10) or C-TACE (n = 7) were analyzed. Venous blood was taken before and immediately after the radiological interventions to isolate and quantify CTCs using flow cytometry. CTCs were identified as CD45- and positive for the markers ASGPR, CD146 and CD274 (PD-L1). Patients were followed of up to 2.2 years after the radiological intervention. CTCs were detected in 13 HCC patients (76%) prior to the radiological interventions. The rate of CTCs was significantly decreased after the intervention in patients treated with MWA (0.4 CTCs/mL of blood, p = 0.031). However, no significant differences were observed in patients who received C-TACE (0.3 CTCs/mL of blood, p = 0.300). Overall, no correlation was found between the CTCs rate before and after the radiological intervention and recurrence rate of HCC. This preliminary data could confirm the tumoricidal effects of MWA in patients with HCC by significantly decreasing CTCs rate. In our study, we were able to detect CTCs in HCC patients using 3 different tumor markers. This preliminary data shows significant lower CTCs detected in response to MWA. However, large-scale randomized clinical trials are needed to determine the future role and the prognostic relevance of CTCs following this treatment. |
| doi_str_mv | 10.1371/journal.pone.0246527 |
| format | Article |
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Additionally, the CTCs short-term dynamics were compared with the clinical course of the HCC-patients. Blood samples from 17 patients with HCC who underwent MWA (n = 10) or C-TACE (n = 7) were analyzed. Venous blood was taken before and immediately after the radiological interventions to isolate and quantify CTCs using flow cytometry. CTCs were identified as CD45- and positive for the markers ASGPR, CD146 and CD274 (PD-L1). Patients were followed of up to 2.2 years after the radiological intervention. CTCs were detected in 13 HCC patients (76%) prior to the radiological interventions. The rate of CTCs was significantly decreased after the intervention in patients treated with MWA (0.4 CTCs/mL of blood, p = 0.031). However, no significant differences were observed in patients who received C-TACE (0.3 CTCs/mL of blood, p = 0.300). Overall, no correlation was found between the CTCs rate before and after the radiological intervention and recurrence rate of HCC. This preliminary data could confirm the tumoricidal effects of MWA in patients with HCC by significantly decreasing CTCs rate. In our study, we were able to detect CTCs in HCC patients using 3 different tumor markers. This preliminary data shows significant lower CTCs detected in response to MWA. However, large-scale randomized clinical trials are needed to determine the future role and the prognostic relevance of CTCs following this treatment.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0246527</identifier><identifier>PMID: 33577574</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Antibodies ; Biology and Life Sciences ; Blood ; Blood cells ; Cancer therapies ; Care and treatment ; Catheters ; Cell adhesion & migration ; Chemotherapy ; Cloning ; Computer programs ; Data analysis ; Diagnosis ; Diagnostic systems ; Editing ; Embolization ; Flow cytometry ; Hepatocellular carcinoma ; Hepatoma ; Hospitals ; Immunofluorescence ; Liver cancer ; Medical instruments ; Medical prognosis ; Medicine and Health Sciences ; Methodology ; Nanotechnology ; Patient outcomes ; Patients ; Peripheral blood ; Physical Sciences ; Physiological aspects ; Prognosis ; Radiology ; Radiotherapy ; Research and Analysis Methods ; Software ; Staining ; Statistical analysis ; Surgery ; Tumor cells ; Tumor markers ; Tumors ; Visualization</subject><ispartof>PloS one, 2021-02, Vol.16 (2), p.e0246527-e0246527</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Vogl et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Vogl et al 2021 Vogl et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-bcfe3e79e129b5583989383f5dfe863c4785cad907f3a037818e768204eb35f13</citedby><cites>FETCH-LOGICAL-c692t-bcfe3e79e129b5583989383f5dfe863c4785cad907f3a037818e768204eb35f13</cites><orcidid>0000-0002-0928-9002 ; 0000-0002-1793-0672</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880472/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880472/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33577574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lanza, Ezio</contributor><creatorcontrib>Vogl, Thomas J</creatorcontrib><creatorcontrib>Riegelbauer, Linda J</creatorcontrib><creatorcontrib>Oppermann, Elsie</creatorcontrib><creatorcontrib>Kostantin, Michel</creatorcontrib><creatorcontrib>Ackermann, Hanns</creatorcontrib><creatorcontrib>Trzmiel, Annette</creatorcontrib><creatorcontrib>Stein, Stefan</creatorcontrib><creatorcontrib>Eichler, Katrin</creatorcontrib><creatorcontrib>Zharov, Vladimir P</creatorcontrib><creatorcontrib>Roy, Dhruvajyoti</creatorcontrib><creatorcontrib>Schnitzbauer, Andreas A</creatorcontrib><creatorcontrib>Strücker, Benjamin</creatorcontrib><creatorcontrib>Pascher, Andreas</creatorcontrib><creatorcontrib>Bechstein, Wolf O</creatorcontrib><creatorcontrib>Juratli, Mazen A</creatorcontrib><title>Early dynamic changes in circulating tumor cells and prognostic relevance following interventional radiological treatments in patients with hepatocellular carcinoma</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The aim of this study was to investigate the dynamic changes of circulating tumor cells (CTCs) in patients with hepatocellular carcinoma (HCC) before and immediately after conducting a microwave ablation (MWA) and conventional transarterial chemoembolization (C-TACE). Additionally, the CTCs short-term dynamics were compared with the clinical course of the HCC-patients. Blood samples from 17 patients with HCC who underwent MWA (n = 10) or C-TACE (n = 7) were analyzed. Venous blood was taken before and immediately after the radiological interventions to isolate and quantify CTCs using flow cytometry. CTCs were identified as CD45- and positive for the markers ASGPR, CD146 and CD274 (PD-L1). Patients were followed of up to 2.2 years after the radiological intervention. CTCs were detected in 13 HCC patients (76%) prior to the radiological interventions. The rate of CTCs was significantly decreased after the intervention in patients treated with MWA (0.4 CTCs/mL of blood, p = 0.031). However, no significant differences were observed in patients who received C-TACE (0.3 CTCs/mL of blood, p = 0.300). Overall, no correlation was found between the CTCs rate before and after the radiological intervention and recurrence rate of HCC. 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Sciences</subject><subject>Methodology</subject><subject>Nanotechnology</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Peripheral blood</subject><subject>Physical Sciences</subject><subject>Physiological aspects</subject><subject>Prognosis</subject><subject>Radiology</subject><subject>Radiotherapy</subject><subject>Research and Analysis Methods</subject><subject>Software</subject><subject>Staining</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Tumor cells</subject><subject>Tumor 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tumor cells and prognostic relevance following interventional radiological treatments in patients with hepatocellular carcinoma</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-02-12</date><risdate>2021</risdate><volume>16</volume><issue>2</issue><spage>e0246527</spage><epage>e0246527</epage><pages>e0246527-e0246527</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The aim of this study was to investigate the dynamic changes of circulating tumor cells (CTCs) in patients with hepatocellular carcinoma (HCC) before and immediately after conducting a microwave ablation (MWA) and conventional transarterial chemoembolization (C-TACE). Additionally, the CTCs short-term dynamics were compared with the clinical course of the HCC-patients. Blood samples from 17 patients with HCC who underwent MWA (n = 10) or C-TACE (n = 7) were analyzed. Venous blood was taken before and immediately after the radiological interventions to isolate and quantify CTCs using flow cytometry. CTCs were identified as CD45- and positive for the markers ASGPR, CD146 and CD274 (PD-L1). Patients were followed of up to 2.2 years after the radiological intervention. CTCs were detected in 13 HCC patients (76%) prior to the radiological interventions. The rate of CTCs was significantly decreased after the intervention in patients treated with MWA (0.4 CTCs/mL of blood, p = 0.031). However, no significant differences were observed in patients who received C-TACE (0.3 CTCs/mL of blood, p = 0.300). Overall, no correlation was found between the CTCs rate before and after the radiological intervention and recurrence rate of HCC. This preliminary data could confirm the tumoricidal effects of MWA in patients with HCC by significantly decreasing CTCs rate. In our study, we were able to detect CTCs in HCC patients using 3 different tumor markers. This preliminary data shows significant lower CTCs detected in response to MWA. However, large-scale randomized clinical trials are needed to determine the future role and the prognostic relevance of CTCs following this treatment.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33577574</pmid><doi>10.1371/journal.pone.0246527</doi><tpages>e0246527</tpages><orcidid>https://orcid.org/0000-0002-0928-9002</orcidid><orcidid>https://orcid.org/0000-0002-1793-0672</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-02, Vol.16 (2), p.e0246527-e0246527 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2489013787 |
| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Antibodies Biology and Life Sciences Blood Blood cells Cancer therapies Care and treatment Catheters Cell adhesion & migration Chemotherapy Cloning Computer programs Data analysis Diagnosis Diagnostic systems Editing Embolization Flow cytometry Hepatocellular carcinoma Hepatoma Hospitals Immunofluorescence Liver cancer Medical instruments Medical prognosis Medicine and Health Sciences Methodology Nanotechnology Patient outcomes Patients Peripheral blood Physical Sciences Physiological aspects Prognosis Radiology Radiotherapy Research and Analysis Methods Software Staining Statistical analysis Surgery Tumor cells Tumor markers Tumors Visualization |
| title | Early dynamic changes in circulating tumor cells and prognostic relevance following interventional radiological treatments in patients with hepatocellular carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T20%3A35%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Early%20dynamic%20changes%20in%20circulating%20tumor%20cells%20and%20prognostic%20relevance%20following%20interventional%20radiological%20treatments%20in%20patients%20with%20hepatocellular%20carcinoma&rft.jtitle=PloS%20one&rft.au=Vogl,%20Thomas%20J&rft.date=2021-02-12&rft.volume=16&rft.issue=2&rft.spage=e0246527&rft.epage=e0246527&rft.pages=e0246527-e0246527&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0246527&rft_dat=%3Cgale_plos_%3EA651631716%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2489013787&rft_id=info:pmid/33577574&rft_galeid=A651631716&rft_doaj_id=oai_doaj_org_article_89395943793244ff895a5d774949f77e&rfr_iscdi=true |