Factors affecting outcome of longer regimen multidrug-resistant tuberculosis treatment in West Java Indonesia: A retrospective cohort study
Multidrug-resistant tuberculosis had high treatment failure and mortality. Success rate of treatment currently 56% at global level, 48% in Indonesia and 36% in West Java province, the most populated province and surround Jakarta, the capitol of Indonesia. This study aimed to evaluate factors affecti...
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| description | Multidrug-resistant tuberculosis had high treatment failure and mortality. Success rate of treatment currently 56% at global level, 48% in Indonesia and 36% in West Java province, the most populated province and surround Jakarta, the capitol of Indonesia.
This study aimed to evaluate factors affecting success of multidrug-resistant tuberculosis treatment in patients using longer treatment regimen in West Java Indonesia.
This was a retrospective cohort study of multidrug-resistant tuberculosis patients treated with longer regimen at Hasan Sadikin General Hospital from January 2015 to December 2017. Potential risk factors associated with the treatment outcome were analyzed using multiple logistic regression.
A total of 492 patients were enrolled during the study period. Fifty percents multidrug-resistant tuberculosis patients had successful treatment outcome. Age ≤45 years, male, normal body mass index, no previous tuberculosis treatment, culture conversion ≤2 months, acid fast bacilli sputum smear ≤+1 were independent factors associated with increased treatment success. Sputum culture conversion ≤2 months was the major factor affecting successful outcome (RR 2.79; 95% CI: 1.61-4.84; p-value |
| doi_str_mv | 10.1371/journal.pone.0246284 |
| format | Article |
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This study aimed to evaluate factors affecting success of multidrug-resistant tuberculosis treatment in patients using longer treatment regimen in West Java Indonesia.
This was a retrospective cohort study of multidrug-resistant tuberculosis patients treated with longer regimen at Hasan Sadikin General Hospital from January 2015 to December 2017. Potential risk factors associated with the treatment outcome were analyzed using multiple logistic regression.
A total of 492 patients were enrolled during the study period. Fifty percents multidrug-resistant tuberculosis patients had successful treatment outcome. Age ≤45 years, male, normal body mass index, no previous tuberculosis treatment, culture conversion ≤2 months, acid fast bacilli sputum smear ≤+1 were independent factors associated with increased treatment success. Sputum culture conversion ≤2 months was the major factor affecting successful outcome (RR 2.79; 95% CI: 1.61-4.84; p-value<0.001). Human Immunodeficiency Virus infection, chronic kidney disease, and cavitary lesion were independent risk factors for unfavourable outcome.
Age, gender, body mass index, tuberculosis treatment history, time of sputum conversion, acid fast bacilli sputum smear, HIV infection, chronic kidney disease, and cavitary lesion can be used as predictors for longer multidrug-resistant tuberculosis treatment regimen outcome.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0246284</identifier><identifier>PMID: 33556094</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Anemia ; Bacilli ; Biology and Life Sciences ; Body mass ; Body mass index ; Body size ; Body weight loss ; Care and treatment ; Clinical outcomes ; Cohort analysis ; Critical care ; Diabetes ; Diabetes mellitus ; Diagnosis ; Drug resistance ; Editing ; Ethambutol ; Health risks ; HIV ; Hospitals ; Human immunodeficiency virus ; Internal medicine ; Isoniazid ; Kidney diseases ; Low income groups ; Medical treatment ; Medicine ; Medicine and Health Sciences ; Multidrug resistance ; Multidrug resistant organisms ; Multivariate analysis ; Patients ; Prognosis ; Public health ; Research facilities ; Reviews ; Rifampin ; Sexually transmitted diseases ; Sputum ; Statistical analysis ; STD ; Streptomycin ; Success ; Thorax ; Tuberculosis ; Viruses ; Weight loss</subject><ispartof>PloS one, 2021-02, Vol.16 (2), p.e0246284-e0246284</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Soeroto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Soeroto et al 2021 Soeroto et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c743t-c8a2cfdac9dfc670378e177bffba36f1dc617b160bee9b0ed96f0b7017814a913</citedby><cites>FETCH-LOGICAL-c743t-c8a2cfdac9dfc670378e177bffba36f1dc617b160bee9b0ed96f0b7017814a913</cites><orcidid>0000-0001-9027-2453 ; 0000-0002-3623-0954</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870080/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870080/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,2098,2917,23853,27911,27912,53778,53780,79355,79356</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33556094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Marotta, Claudia</contributor><creatorcontrib>Soeroto, Arto Yuwono</creatorcontrib><creatorcontrib>Pratiwi, Chica</creatorcontrib><creatorcontrib>Santoso, Prayudi</creatorcontrib><creatorcontrib>Lestari, Bony Wiem</creatorcontrib><title>Factors affecting outcome of longer regimen multidrug-resistant tuberculosis treatment in West Java Indonesia: A retrospective cohort study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Multidrug-resistant tuberculosis had high treatment failure and mortality. Success rate of treatment currently 56% at global level, 48% in Indonesia and 36% in West Java province, the most populated province and surround Jakarta, the capitol of Indonesia.
This study aimed to evaluate factors affecting success of multidrug-resistant tuberculosis treatment in patients using longer treatment regimen in West Java Indonesia.
This was a retrospective cohort study of multidrug-resistant tuberculosis patients treated with longer regimen at Hasan Sadikin General Hospital from January 2015 to December 2017. Potential risk factors associated with the treatment outcome were analyzed using multiple logistic regression.
A total of 492 patients were enrolled during the study period. Fifty percents multidrug-resistant tuberculosis patients had successful treatment outcome. Age ≤45 years, male, normal body mass index, no previous tuberculosis treatment, culture conversion ≤2 months, acid fast bacilli sputum smear ≤+1 were independent factors associated with increased treatment success. Sputum culture conversion ≤2 months was the major factor affecting successful outcome (RR 2.79; 95% CI: 1.61-4.84; p-value<0.001). Human Immunodeficiency Virus infection, chronic kidney disease, and cavitary lesion were independent risk factors for unfavourable outcome.
Age, gender, body mass index, tuberculosis treatment history, time of sputum conversion, acid fast bacilli sputum smear, HIV infection, chronic kidney disease, and cavitary lesion can be used as predictors for longer multidrug-resistant tuberculosis treatment regimen outcome.</description><subject>Anemia</subject><subject>Bacilli</subject><subject>Biology and Life Sciences</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Body weight loss</subject><subject>Care and treatment</subject><subject>Clinical outcomes</subject><subject>Cohort analysis</subject><subject>Critical care</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diagnosis</subject><subject>Drug resistance</subject><subject>Editing</subject><subject>Ethambutol</subject><subject>Health risks</subject><subject>HIV</subject><subject>Hospitals</subject><subject>Human immunodeficiency virus</subject><subject>Internal medicine</subject><subject>Isoniazid</subject><subject>Kidney diseases</subject><subject>Low income groups</subject><subject>Medical treatment</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Multidrug resistance</subject><subject>Multidrug resistant organisms</subject><subject>Multivariate analysis</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Public health</subject><subject>Research facilities</subject><subject>Reviews</subject><subject>Rifampin</subject><subject>Sexually transmitted diseases</subject><subject>Sputum</subject><subject>Statistical analysis</subject><subject>STD</subject><subject>Streptomycin</subject><subject>Success</subject><subject>Thorax</subject><subject>Tuberculosis</subject><subject>Viruses</subject><subject>Weight 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affecting outcome of longer regimen multidrug-resistant tuberculosis treatment in West Java Indonesia: A retrospective cohort study</title><author>Soeroto, Arto Yuwono ; Pratiwi, Chica ; Santoso, Prayudi ; Lestari, Bony Wiem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c743t-c8a2cfdac9dfc670378e177bffba36f1dc617b160bee9b0ed96f0b7017814a913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anemia</topic><topic>Bacilli</topic><topic>Biology and Life Sciences</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Body weight loss</topic><topic>Care and treatment</topic><topic>Clinical outcomes</topic><topic>Cohort analysis</topic><topic>Critical care</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diagnosis</topic><topic>Drug resistance</topic><topic>Editing</topic><topic>Ethambutol</topic><topic>Health 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tuberculosis treatment in West Java Indonesia: A retrospective cohort study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-02-08</date><risdate>2021</risdate><volume>16</volume><issue>2</issue><spage>e0246284</spage><epage>e0246284</epage><pages>e0246284-e0246284</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Multidrug-resistant tuberculosis had high treatment failure and mortality. Success rate of treatment currently 56% at global level, 48% in Indonesia and 36% in West Java province, the most populated province and surround Jakarta, the capitol of Indonesia.
This study aimed to evaluate factors affecting success of multidrug-resistant tuberculosis treatment in patients using longer treatment regimen in West Java Indonesia.
This was a retrospective cohort study of multidrug-resistant tuberculosis patients treated with longer regimen at Hasan Sadikin General Hospital from January 2015 to December 2017. Potential risk factors associated with the treatment outcome were analyzed using multiple logistic regression.
A total of 492 patients were enrolled during the study period. Fifty percents multidrug-resistant tuberculosis patients had successful treatment outcome. Age ≤45 years, male, normal body mass index, no previous tuberculosis treatment, culture conversion ≤2 months, acid fast bacilli sputum smear ≤+1 were independent factors associated with increased treatment success. Sputum culture conversion ≤2 months was the major factor affecting successful outcome (RR 2.79; 95% CI: 1.61-4.84; p-value<0.001). Human Immunodeficiency Virus infection, chronic kidney disease, and cavitary lesion were independent risk factors for unfavourable outcome.
Age, gender, body mass index, tuberculosis treatment history, time of sputum conversion, acid fast bacilli sputum smear, HIV infection, chronic kidney disease, and cavitary lesion can be used as predictors for longer multidrug-resistant tuberculosis treatment regimen outcome.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33556094</pmid><doi>10.1371/journal.pone.0246284</doi><tpages>e0246284</tpages><orcidid>https://orcid.org/0000-0001-9027-2453</orcidid><orcidid>https://orcid.org/0000-0002-3623-0954</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Anemia Bacilli Biology and Life Sciences Body mass Body mass index Body size Body weight loss Care and treatment Clinical outcomes Cohort analysis Critical care Diabetes Diabetes mellitus Diagnosis Drug resistance Editing Ethambutol Health risks HIV Hospitals Human immunodeficiency virus Internal medicine Isoniazid Kidney diseases Low income groups Medical treatment Medicine Medicine and Health Sciences Multidrug resistance Multidrug resistant organisms Multivariate analysis Patients Prognosis Public health Research facilities Reviews Rifampin Sexually transmitted diseases Sputum Statistical analysis STD Streptomycin Success Thorax Tuberculosis Viruses Weight loss |
| title | Factors affecting outcome of longer regimen multidrug-resistant tuberculosis treatment in West Java Indonesia: A retrospective cohort study |
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