Newly-found channels in the interatrial septum of the heart by dissection, histologic evaluation, and three-dimensional microcomputed tomography
A minute thrombus can pass through a small type of interatrial communication, which can result in a stroke or transient ischemic attack and several associated symptoms. This study sought to investigate a new type of interatrial communication. Thirty-one hearts from embalmed adult cadavers were inves...
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description | A minute thrombus can pass through a small type of interatrial communication, which can result in a stroke or transient ischemic attack and several associated symptoms. This study sought to investigate a new type of interatrial communication. Thirty-one hearts from embalmed adult cadavers were investigated. Each interatrial channels (IACs) was classified as either an open or obstructed channel according to the connection of each hole on the right and left surfaces of the interatrial septum. Open channels were found in two specimens (6.5%). Both open and obstructed IACs followed tortuous courses through the interatrial septum. On the right surface of the interatrial septum, the hole was usually found adjacent to the left border of the interatrial septum between the opening of the superior vena cava into the right atrium and the superior margin of the fossa ovalis. Conversely, holes on the left surface of the interatrial septum were usually found in the upper and middle parts adjacent to the left border of the interatrial septum. This novel finding is expected to support our understanding of the onset of possible symptoms such as stroke in the absence of classical atrial septal defects. |
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This study sought to investigate a new type of interatrial communication. Thirty-one hearts from embalmed adult cadavers were investigated. Each interatrial channels (IACs) was classified as either an open or obstructed channel according to the connection of each hole on the right and left surfaces of the interatrial septum. Open channels were found in two specimens (6.5%). Both open and obstructed IACs followed tortuous courses through the interatrial septum. On the right surface of the interatrial septum, the hole was usually found adjacent to the left border of the interatrial septum between the opening of the superior vena cava into the right atrium and the superior margin of the fossa ovalis. Conversely, holes on the left surface of the interatrial septum were usually found in the upper and middle parts adjacent to the left border of the interatrial septum. This novel finding is expected to support our understanding of the onset of possible symptoms such as stroke in the absence of classical atrial septal defects.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0246585</identifier><identifier>PMID: 33556133</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and Life Sciences ; Communication ; Computed tomography ; Dissection ; Editing ; Embolisms ; Funding ; Health care facilities ; Heart septum ; HuR protein ; Medical examination ; Medicine ; Medicine and Health Sciences ; Methodology ; Morphology ; Perfluorooctane sulfonic acid ; Physiological aspects ; Radiology ; Research and Analysis Methods ; Reviews ; Risk factors ; Septum ; Software packages ; Stroke ; Stroke (Disease) ; Thromboembolism ; Transient ischemic attack ; Visualization</subject><ispartof>PloS one, 2021-02, Vol.16 (2), p.e0246585-e0246585</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Hur et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Hur et al 2021 Hur et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c641t-d2e0052c9fb22868a53c62dd3b9a60811afaae39dd95272b00b402a6a1ec9c8d3</cites><orcidid>0000-0002-7767-931X ; 0000-0003-3141-6968</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869977/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869977/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23868,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33556133$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Holda, Mateusz K.</contributor><creatorcontrib>Hur, Mi-Sun</creatorcontrib><creatorcontrib>Lee, Seunggyu</creatorcontrib><creatorcontrib>Oh, Chang-Seok</creatorcontrib><creatorcontrib>Choe, Yeon Hyeon</creatorcontrib><title>Newly-found channels in the interatrial septum of the heart by dissection, histologic evaluation, and three-dimensional microcomputed tomography</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>A minute thrombus can pass through a small type of interatrial communication, which can result in a stroke or transient ischemic attack and several associated symptoms. This study sought to investigate a new type of interatrial communication. Thirty-one hearts from embalmed adult cadavers were investigated. Each interatrial channels (IACs) was classified as either an open or obstructed channel according to the connection of each hole on the right and left surfaces of the interatrial septum. Open channels were found in two specimens (6.5%). Both open and obstructed IACs followed tortuous courses through the interatrial septum. On the right surface of the interatrial septum, the hole was usually found adjacent to the left border of the interatrial septum between the opening of the superior vena cava into the right atrium and the superior margin of the fossa ovalis. Conversely, holes on the left surface of the interatrial septum were usually found in the upper and middle parts adjacent to the left border of the interatrial septum. This novel finding is expected to support our understanding of the onset of possible symptoms such as stroke in the absence of classical atrial septal defects.</description><subject>Biology and Life Sciences</subject><subject>Communication</subject><subject>Computed tomography</subject><subject>Dissection</subject><subject>Editing</subject><subject>Embolisms</subject><subject>Funding</subject><subject>Health care facilities</subject><subject>Heart septum</subject><subject>HuR protein</subject><subject>Medical examination</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Methodology</subject><subject>Morphology</subject><subject>Perfluorooctane sulfonic acid</subject><subject>Physiological aspects</subject><subject>Radiology</subject><subject>Research and Analysis Methods</subject><subject>Reviews</subject><subject>Risk factors</subject><subject>Septum</subject><subject>Software packages</subject><subject>Stroke</subject><subject>Stroke 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aspects</topic><topic>Radiology</topic><topic>Research and Analysis Methods</topic><topic>Reviews</topic><topic>Risk factors</topic><topic>Septum</topic><topic>Software packages</topic><topic>Stroke</topic><topic>Stroke (Disease)</topic><topic>Thromboembolism</topic><topic>Transient ischemic attack</topic><topic>Visualization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hur, Mi-Sun</creatorcontrib><creatorcontrib>Lee, Seunggyu</creatorcontrib><creatorcontrib>Oh, Chang-Seok</creatorcontrib><creatorcontrib>Choe, Yeon Hyeon</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research 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Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hur, Mi-Sun</au><au>Lee, Seunggyu</au><au>Oh, Chang-Seok</au><au>Choe, Yeon Hyeon</au><au>Holda, Mateusz K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Newly-found channels in the interatrial septum of the heart by dissection, histologic evaluation, and three-dimensional microcomputed tomography</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-02-08</date><risdate>2021</risdate><volume>16</volume><issue>2</issue><spage>e0246585</spage><epage>e0246585</epage><pages>e0246585-e0246585</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>A minute thrombus can pass through a small type of interatrial communication, which can result in a stroke or transient ischemic attack and several associated symptoms. This study sought to investigate a new type of interatrial communication. Thirty-one hearts from embalmed adult cadavers were investigated. Each interatrial channels (IACs) was classified as either an open or obstructed channel according to the connection of each hole on the right and left surfaces of the interatrial septum. Open channels were found in two specimens (6.5%). Both open and obstructed IACs followed tortuous courses through the interatrial septum. On the right surface of the interatrial septum, the hole was usually found adjacent to the left border of the interatrial septum between the opening of the superior vena cava into the right atrium and the superior margin of the fossa ovalis. Conversely, holes on the left surface of the interatrial septum were usually found in the upper and middle parts adjacent to the left border of the interatrial septum. This novel finding is expected to support our understanding of the onset of possible symptoms such as stroke in the absence of classical atrial septal defects.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33556133</pmid><doi>10.1371/journal.pone.0246585</doi><tpages>e0246585</tpages><orcidid>https://orcid.org/0000-0002-7767-931X</orcidid><orcidid>https://orcid.org/0000-0003-3141-6968</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Biology and Life Sciences Communication Computed tomography Dissection Editing Embolisms Funding Health care facilities Heart septum HuR protein Medical examination Medicine Medicine and Health Sciences Methodology Morphology Perfluorooctane sulfonic acid Physiological aspects Radiology Research and Analysis Methods Reviews Risk factors Septum Software packages Stroke Stroke (Disease) Thromboembolism Transient ischemic attack Visualization |
title | Newly-found channels in the interatrial septum of the heart by dissection, histologic evaluation, and three-dimensional microcomputed tomography |
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