Knockdown of Alpha-1 Antitrypsin with antisense oligonucleotide does not exacerbate smoke induced lung injury

Alpha-1 Antitrypsin (AAT) is a serum protease inhibitor that regulates increased lung protease production induced by cigarette smoking. Mutations in the Serpina1 gene cause AAT to form hepatoxic polymers, which can lead to reduced availability for the protein's primary function and severe liver...

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Veröffentlicht in:	PloS one 2021-02, Vol.16 (2), p.e0246040-e0246040
Hauptverfasser:	Stearns, Kyle, Goldklang, Monica, Xiao, Rui, Zelonina, Tina, Blomenkamp, Keith, Teckman, Jeffery, D'Armiento, Jeanine M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antisense oligonucleotides Biochemistry Biology and Life Sciences Chronic obstructive pulmonary disease Cirrhosis Computer programs Data analysis Development and progression Drafting software Editing Exposure Funding Gene expression Health aspects Health care facilities Infections Inflammation Influenza Injuries Injury analysis Laboratories Liver cirrhosis Liver diseases Lung diseases Lungs Medical personnel Medicine and Health Sciences Methodology Molecular biology Neutrophils Oligonucleotides Physicians Protease Protease inhibitors Protein folding Proteinase inhibitors Research and Analysis Methods Risk factors Smoke Smoking Social Sciences Software Surgeons Ventilators Visualization
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