Polycystic ovary syndrome and extremely preterm birth: A nationwide register-based study
Women with polycystic ovary syndrome (PCOS) have increased risk of pregnancy complications, including preterm birth before 37 weeks. However, if this increased risk also includes extremely preterm births (
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| Veröffentlicht in: | PloS one 2021-02, Vol.16 (2), p.e0246743-e0246743 |
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| creator | Valgeirsdottir, Heiddis Sundström Poromaa, Inger Kunovac Kallak, Theodora Vanky, Eszter Akhter, Tansim Roos, Nathalie Stephansson, Olof Wikström, Anna-Karin |
| description | Women with polycystic ovary syndrome (PCOS) have increased risk of pregnancy complications, including preterm birth before 37 weeks. However, if this increased risk also includes extremely preterm births ( |
| doi_str_mv | 10.1371/journal.pone.0246743 |
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To investigate the association between PCOS and extremely preterm birth, and whether onset of PCOS-related preterm birth is predominantly spontaneous or medically indicated.
This was a nationwide register-based cohort study in Sweden. The study population was all live singleton births registered in the Swedish Medical Birth Register 2005-2014 (n = 1 046 448). Women with and without PCOS were compared by severity of preterm birth [extremely (22+0 to 27+6 weeks), very (28+0 to 31+6 weeks) and moderately (32+0 to 36+6 weeks)] and delivery onset mode (spontaneous or medically indicated). Multinomial logistic regression was performed to estimate adjusted odds ratios (aOR) with 95% confidence intervals (CI). Adjustments were made for maternal age, parity, body mass index, smoking, country of birth and year of delivery.
During the study period, 1.3% of the women giving birth had PCOS diagnosis. They had an overall higher preterm birth rate than women without PCOS (6.7% and 4.8%, respectively). Women with PCOS had increased odds of preterm birth of all severities, with the highest odds for extremely preterm birth (aOR 2.3; 95% CI 1.7-3.0), particularly of spontaneous onset (aOR 2.7; 95% CI 2.0-3.6).
Women with PCOS had more than a two-fold increased risk of extremely preterm birth with spontaneous onset than women without such diagnosis. This can be important in antenatal risk assessment of preterm birth in women with PCOS. Future research is warranted to investigate the biological mechanisms behind preterm birth in women with PCOS.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0246743</identifier><identifier>PMID: 33539479</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Cervix ; Cesarean section ; Complications and side effects ; Diabetes ; Diagnosis ; Epidemiology ; Gestational age ; Health risks ; Hospitals ; Infants (Premature) ; Medicine ; Medicine and Health Sciences ; Menstruation ; Obstetrics ; Obstetrics and Gynaecology ; Obstetrik och gynekologi ; Ovaries ; People and places ; Personal identification numbers ; Polycystic ovary syndrome ; Population ; Pregnancy ; Premature birth ; Risk factors ; Stein-Leventhal syndrome ; Vagina ; Womens health</subject><ispartof>PloS one, 2021-02, Vol.16 (2), p.e0246743-e0246743</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Valgeirsdottir et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Valgeirsdottir et al 2021 Valgeirsdottir et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c660t-8d6cf8ed722f0f0f38b448eb35a4136c2f17adbdd6f0ee6132b49057e50b4e4b3</citedby><cites>FETCH-LOGICAL-c660t-8d6cf8ed722f0f0f38b448eb35a4136c2f17adbdd6f0ee6132b49057e50b4e4b3</cites><orcidid>0000-0002-7926-5583 ; 0000-0002-2112-8674</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861420/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861420/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33539479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-435475$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:146089428$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Valgeirsdottir, Heiddis</creatorcontrib><creatorcontrib>Sundström Poromaa, Inger</creatorcontrib><creatorcontrib>Kunovac Kallak, Theodora</creatorcontrib><creatorcontrib>Vanky, Eszter</creatorcontrib><creatorcontrib>Akhter, Tansim</creatorcontrib><creatorcontrib>Roos, Nathalie</creatorcontrib><creatorcontrib>Stephansson, Olof</creatorcontrib><creatorcontrib>Wikström, Anna-Karin</creatorcontrib><title>Polycystic ovary syndrome and extremely preterm birth: A nationwide register-based study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Women with polycystic ovary syndrome (PCOS) have increased risk of pregnancy complications, including preterm birth before 37 weeks. However, if this increased risk also includes extremely preterm births (<28 weeks) is unknown. Such information is important to identify women at risk and tailor antenatal care, since child morbidity and mortality become more prevalent with increasing prematurity.
To investigate the association between PCOS and extremely preterm birth, and whether onset of PCOS-related preterm birth is predominantly spontaneous or medically indicated.
This was a nationwide register-based cohort study in Sweden. The study population was all live singleton births registered in the Swedish Medical Birth Register 2005-2014 (n = 1 046 448). Women with and without PCOS were compared by severity of preterm birth [extremely (22+0 to 27+6 weeks), very (28+0 to 31+6 weeks) and moderately (32+0 to 36+6 weeks)] and delivery onset mode (spontaneous or medically indicated). Multinomial logistic regression was performed to estimate adjusted odds ratios (aOR) with 95% confidence intervals (CI). Adjustments were made for maternal age, parity, body mass index, smoking, country of birth and year of delivery.
During the study period, 1.3% of the women giving birth had PCOS diagnosis. They had an overall higher preterm birth rate than women without PCOS (6.7% and 4.8%, respectively). Women with PCOS had increased odds of preterm birth of all severities, with the highest odds for extremely preterm birth (aOR 2.3; 95% CI 1.7-3.0), particularly of spontaneous onset (aOR 2.7; 95% CI 2.0-3.6).
Women with PCOS had more than a two-fold increased risk of extremely preterm birth with spontaneous onset than women without such diagnosis. This can be important in antenatal risk assessment of preterm birth in women with PCOS. Future research is warranted to investigate the biological mechanisms behind preterm birth in women with PCOS.</description><subject>Cervix</subject><subject>Cesarean section</subject><subject>Complications and side effects</subject><subject>Diabetes</subject><subject>Diagnosis</subject><subject>Epidemiology</subject><subject>Gestational age</subject><subject>Health risks</subject><subject>Hospitals</subject><subject>Infants (Premature)</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Menstruation</subject><subject>Obstetrics</subject><subject>Obstetrics and Gynaecology</subject><subject>Obstetrik och gynekologi</subject><subject>Ovaries</subject><subject>People and places</subject><subject>Personal identification numbers</subject><subject>Polycystic ovary syndrome</subject><subject>Population</subject><subject>Pregnancy</subject><subject>Premature birth</subject><subject>Risk factors</subject><subject>Stein-Leventhal syndrome</subject><subject>Vagina</subject><subject>Womens 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ovary syndrome and extremely preterm birth: A nationwide register-based study</title><author>Valgeirsdottir, Heiddis ; Sundström Poromaa, Inger ; Kunovac Kallak, Theodora ; Vanky, Eszter ; Akhter, Tansim ; Roos, Nathalie ; Stephansson, Olof ; Wikström, Anna-Karin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c660t-8d6cf8ed722f0f0f38b448eb35a4136c2f17adbdd6f0ee6132b49057e50b4e4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cervix</topic><topic>Cesarean section</topic><topic>Complications and side effects</topic><topic>Diabetes</topic><topic>Diagnosis</topic><topic>Epidemiology</topic><topic>Gestational age</topic><topic>Health risks</topic><topic>Hospitals</topic><topic>Infants (Premature)</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Menstruation</topic><topic>Obstetrics</topic><topic>Obstetrics and 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Valgeirsdottir, Heiddis</au><au>Sundström Poromaa, Inger</au><au>Kunovac Kallak, Theodora</au><au>Vanky, Eszter</au><au>Akhter, Tansim</au><au>Roos, Nathalie</au><au>Stephansson, Olof</au><au>Wikström, Anna-Karin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polycystic ovary syndrome and extremely preterm birth: A nationwide register-based study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-02-04</date><risdate>2021</risdate><volume>16</volume><issue>2</issue><spage>e0246743</spage><epage>e0246743</epage><pages>e0246743-e0246743</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Women with polycystic ovary syndrome (PCOS) have increased risk of pregnancy complications, including preterm birth before 37 weeks. However, if this increased risk also includes extremely preterm births (<28 weeks) is unknown. Such information is important to identify women at risk and tailor antenatal care, since child morbidity and mortality become more prevalent with increasing prematurity.
To investigate the association between PCOS and extremely preterm birth, and whether onset of PCOS-related preterm birth is predominantly spontaneous or medically indicated.
This was a nationwide register-based cohort study in Sweden. The study population was all live singleton births registered in the Swedish Medical Birth Register 2005-2014 (n = 1 046 448). Women with and without PCOS were compared by severity of preterm birth [extremely (22+0 to 27+6 weeks), very (28+0 to 31+6 weeks) and moderately (32+0 to 36+6 weeks)] and delivery onset mode (spontaneous or medically indicated). Multinomial logistic regression was performed to estimate adjusted odds ratios (aOR) with 95% confidence intervals (CI). Adjustments were made for maternal age, parity, body mass index, smoking, country of birth and year of delivery.
During the study period, 1.3% of the women giving birth had PCOS diagnosis. They had an overall higher preterm birth rate than women without PCOS (6.7% and 4.8%, respectively). Women with PCOS had increased odds of preterm birth of all severities, with the highest odds for extremely preterm birth (aOR 2.3; 95% CI 1.7-3.0), particularly of spontaneous onset (aOR 2.7; 95% CI 2.0-3.6).
Women with PCOS had more than a two-fold increased risk of extremely preterm birth with spontaneous onset than women without such diagnosis. This can be important in antenatal risk assessment of preterm birth in women with PCOS. Future research is warranted to investigate the biological mechanisms behind preterm birth in women with PCOS.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33539479</pmid><doi>10.1371/journal.pone.0246743</doi><orcidid>https://orcid.org/0000-0002-7926-5583</orcidid><orcidid>https://orcid.org/0000-0002-2112-8674</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2021-02, Vol.16 (2), p.e0246743-e0246743 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | Public Library of Science (PLoS) Journals Open Access; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online; Free Full-Text Journals in Chemistry |
| subjects | Cervix Cesarean section Complications and side effects Diabetes Diagnosis Epidemiology Gestational age Health risks Hospitals Infants (Premature) Medicine Medicine and Health Sciences Menstruation Obstetrics Obstetrics and Gynaecology Obstetrik och gynekologi Ovaries People and places Personal identification numbers Polycystic ovary syndrome Population Pregnancy Premature birth Risk factors Stein-Leventhal syndrome Vagina Womens health |
| title | Polycystic ovary syndrome and extremely preterm birth: A nationwide register-based study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T22%3A41%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Polycystic%20ovary%20syndrome%20and%20extremely%20preterm%20birth:%20A%20nationwide%20register-based%20study&rft.jtitle=PloS%20one&rft.au=Valgeirsdottir,%20Heiddis&rft.date=2021-02-04&rft.volume=16&rft.issue=2&rft.spage=e0246743&rft.epage=e0246743&rft.pages=e0246743-e0246743&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0246743&rft_dat=%3Cgale_plos_%3EA650730752%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2486455681&rft_id=info:pmid/33539479&rft_galeid=A650730752&rft_doaj_id=oai_doaj_org_article_1f11d338cce749d9b0c12c0af22d82fe&rfr_iscdi=true |