Higher plasma drug levels in elderly people living with HIV treated with darunavir

The proportion of elderly people living with HIV-1 (PLHIV) is rising. In older patients, comorbidities and concomitant medications are more frequent, increasing the risk of potential drug-drug interactions (PDDIs). Data on the pharmacokinetics of ART in individuals aged ≥ 65 years of age are scarce....

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Veröffentlicht in:	PloS one 2021-02, Vol.16 (2), p.e0246171
Hauptverfasser:	Tyrberg, Erika, Edén, Arvid, Eriksen, Jaran, Nilsson, Staffan, Treutiger, Carl Johan, Thalme, Anders, Mellgren, Åsa, Gisslén, Magnus, Andersson, Lars-Magnus
Format:	Artikel
Sprache:	eng
Schlagworte:	adherence Age Aged patients Antiretroviral agents Antiretroviral drugs antiretroviral medications Antiretroviral therapy Biology and Life Sciences Care and treatment Chromatography Clinical Medicine Complications and side effects Darunavir Demographic aspects Diagnosis Dosage and administration Drug dosages Drug interactions Drug therapy Editing Efavirenz Funding Health risks High performance liquid chromatography High pressure HIV HIV infection Hospitals Human immunodeficiency virus individuals infection Infectious diseases Integrase Klinisk medicin Laboratories Life expectancy Life span Liquid chromatography Medicin och hälsovetenskap Medicine and Health Sciences Nucleosides older Older people People and Places Pharmacology Plasma polypharmacy population Prescription drugs Protease inhibitors Proteinase inhibitors Public health Questionnaires Reviews risk Risk factors Science & Technology - Other Topics survival
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