Longitudinal telomere length and body composition in healthy term-born infants during the first two years of life
Leukocyte telomere length (LTL) is one of the markers of biological aging as shortening occurs over time. Shorter LTL has been associated with adiposity and a higher risk of cardiovascular diseases. The objective was to assess LTL and LTL shortening during the first 2 years of life in healthy, term-...
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| creator | de Fluiter, Kirsten S Codd, Veryan Denniff, Matthew Kerkhof, Gerthe F van Beijsterveldt, Inge A L P Breij, Laura M Samani, Nilesh J Abrahamse-Berkeveld, Marieke Hokken-Koelega, Anita C S |
| description | Leukocyte telomere length (LTL) is one of the markers of biological aging as shortening occurs over time. Shorter LTL has been associated with adiposity and a higher risk of cardiovascular diseases. The objective was to assess LTL and LTL shortening during the first 2 years of life in healthy, term-born infants and to associate LTL shortening with potential stressors and body composition.
In 145 healthy, term-born infants (85 boys), we measured LTL in blood, expressed as telomere to single-gene copy ratio (T/S ratio), at 3 months and 2 years by quantitative PCR technique. Fat mass (FM) was assessed longitudinally by PEAPOD, DXA, and abdominal FM by ultrasound.
LTL decreased by 8.5% from 3 months to 2 years (T/S ratio 4.10 vs 3.75, p |
| doi_str_mv | 10.1371/journal.pone.0246400 |
| format | Article |
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In 145 healthy, term-born infants (85 boys), we measured LTL in blood, expressed as telomere to single-gene copy ratio (T/S ratio), at 3 months and 2 years by quantitative PCR technique. Fat mass (FM) was assessed longitudinally by PEAPOD, DXA, and abdominal FM by ultrasound.
LTL decreased by 8.5% from 3 months to 2 years (T/S ratio 4.10 vs 3.75, p<0.001). LTL shortening from 3 months to 2 years associated with FM%(R = 0.254), FM index(R = 0.243) and visceral FM(R = 0.287) at 2 years. LTL shortening tended to associate with gain in FM% from 3 to 6 months (R = 0.155, p = 0.11), in the critical window for adiposity programming. There was a trend to a shorter LTL in boys at 2 years(p = 0.056). LTL shortening from 3 months to 2 years was not different between sexes.
We present longitudinal LTL values and show that LTL shortens considerably (8.5%) during the first 2 years of life. LTL shortening during first 2 years of life was associated with FM%, FMI and visceral FM at age 2 years, suggesting that adverse adiposity programming in early life could contribute to more LTL shortening.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0246400</identifier><identifier>PMID: 33529269</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adipose tissue ; Babies ; Biology and Life Sciences ; Biomedical research ; Body composition ; Body size ; Breastfeeding & lactation ; Cell division ; Children ; Chromosomes ; Demographic aspects ; Deoxyribonucleic acid ; DNA ; Editing ; Endocrinology ; Funding ; Gene sequencing ; Gestational age ; Health care facilities ; Infants ; Leukocytes ; Measurement ; Medical research ; Medicine and Health Sciences ; Nucleotide sequence ; Pediatrics ; People and Places ; Physiological aspects ; Protocol (computers) ; Reviews ; Telomerase ; Telomeres ; Ultrasonic imaging</subject><ispartof>PloS one, 2021-02, Vol.16 (2), p.e0246400-e0246400</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 de Fluiter et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 de Fluiter et al 2021 de Fluiter et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-43bce80607cb0a363afc387e52afda77a5d5a4f87dbfd3cea7935133ad0827fb3</citedby><cites>FETCH-LOGICAL-c692t-43bce80607cb0a363afc387e52afda77a5d5a4f87dbfd3cea7935133ad0827fb3</cites><orcidid>0000-0002-5848-7929</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853438/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853438/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33529269$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Saretzki, Gabriele</contributor><creatorcontrib>de Fluiter, Kirsten S</creatorcontrib><creatorcontrib>Codd, Veryan</creatorcontrib><creatorcontrib>Denniff, Matthew</creatorcontrib><creatorcontrib>Kerkhof, Gerthe F</creatorcontrib><creatorcontrib>van Beijsterveldt, Inge A L P</creatorcontrib><creatorcontrib>Breij, Laura M</creatorcontrib><creatorcontrib>Samani, Nilesh J</creatorcontrib><creatorcontrib>Abrahamse-Berkeveld, Marieke</creatorcontrib><creatorcontrib>Hokken-Koelega, Anita C S</creatorcontrib><title>Longitudinal telomere length and body composition in healthy term-born infants during the first two years of life</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Leukocyte telomere length (LTL) is one of the markers of biological aging as shortening occurs over time. Shorter LTL has been associated with adiposity and a higher risk of cardiovascular diseases. The objective was to assess LTL and LTL shortening during the first 2 years of life in healthy, term-born infants and to associate LTL shortening with potential stressors and body composition.
In 145 healthy, term-born infants (85 boys), we measured LTL in blood, expressed as telomere to single-gene copy ratio (T/S ratio), at 3 months and 2 years by quantitative PCR technique. Fat mass (FM) was assessed longitudinally by PEAPOD, DXA, and abdominal FM by ultrasound.
LTL decreased by 8.5% from 3 months to 2 years (T/S ratio 4.10 vs 3.75, p<0.001). LTL shortening from 3 months to 2 years associated with FM%(R = 0.254), FM index(R = 0.243) and visceral FM(R = 0.287) at 2 years. LTL shortening tended to associate with gain in FM% from 3 to 6 months (R = 0.155, p = 0.11), in the critical window for adiposity programming. There was a trend to a shorter LTL in boys at 2 years(p = 0.056). LTL shortening from 3 months to 2 years was not different between sexes.
We present longitudinal LTL values and show that LTL shortens considerably (8.5%) during the first 2 years of life. LTL shortening during first 2 years of life was associated with FM%, FMI and visceral FM at age 2 years, suggesting that adverse adiposity programming in early life could contribute to more LTL shortening.</description><subject>Adipose tissue</subject><subject>Babies</subject><subject>Biology and Life Sciences</subject><subject>Biomedical research</subject><subject>Body composition</subject><subject>Body size</subject><subject>Breastfeeding & lactation</subject><subject>Cell division</subject><subject>Children</subject><subject>Chromosomes</subject><subject>Demographic aspects</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Editing</subject><subject>Endocrinology</subject><subject>Funding</subject><subject>Gene sequencing</subject><subject>Gestational age</subject><subject>Health care facilities</subject><subject>Infants</subject><subject>Leukocytes</subject><subject>Measurement</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Nucleotide sequence</subject><subject>Pediatrics</subject><subject>People and Places</subject><subject>Physiological aspects</subject><subject>Protocol (computers)</subject><subject>Reviews</subject><subject>Telomerase</subject><subject>Telomeres</subject><subject>Ultrasonic 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telomere length and body composition in healthy term-born infants during the first two years of life</title><author>de Fluiter, Kirsten S ; Codd, Veryan ; Denniff, Matthew ; Kerkhof, Gerthe F ; van Beijsterveldt, Inge A L P ; Breij, Laura M ; Samani, Nilesh J ; Abrahamse-Berkeveld, Marieke ; Hokken-Koelega, Anita C S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-43bce80607cb0a363afc387e52afda77a5d5a4f87dbfd3cea7935133ad0827fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adipose tissue</topic><topic>Babies</topic><topic>Biology and Life Sciences</topic><topic>Biomedical research</topic><topic>Body composition</topic><topic>Body size</topic><topic>Breastfeeding & lactation</topic><topic>Cell division</topic><topic>Children</topic><topic>Chromosomes</topic><topic>Demographic aspects</topic><topic>Deoxyribonucleic 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Gabriele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal telomere length and body composition in healthy term-born infants during the first two years of life</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-02-02</date><risdate>2021</risdate><volume>16</volume><issue>2</issue><spage>e0246400</spage><epage>e0246400</epage><pages>e0246400-e0246400</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Leukocyte telomere length (LTL) is one of the markers of biological aging as shortening occurs over time. Shorter LTL has been associated with adiposity and a higher risk of cardiovascular diseases. The objective was to assess LTL and LTL shortening during the first 2 years of life in healthy, term-born infants and to associate LTL shortening with potential stressors and body composition.
In 145 healthy, term-born infants (85 boys), we measured LTL in blood, expressed as telomere to single-gene copy ratio (T/S ratio), at 3 months and 2 years by quantitative PCR technique. Fat mass (FM) was assessed longitudinally by PEAPOD, DXA, and abdominal FM by ultrasound.
LTL decreased by 8.5% from 3 months to 2 years (T/S ratio 4.10 vs 3.75, p<0.001). LTL shortening from 3 months to 2 years associated with FM%(R = 0.254), FM index(R = 0.243) and visceral FM(R = 0.287) at 2 years. LTL shortening tended to associate with gain in FM% from 3 to 6 months (R = 0.155, p = 0.11), in the critical window for adiposity programming. There was a trend to a shorter LTL in boys at 2 years(p = 0.056). LTL shortening from 3 months to 2 years was not different between sexes.
We present longitudinal LTL values and show that LTL shortens considerably (8.5%) during the first 2 years of life. LTL shortening during first 2 years of life was associated with FM%, FMI and visceral FM at age 2 years, suggesting that adverse adiposity programming in early life could contribute to more LTL shortening.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33529269</pmid><doi>10.1371/journal.pone.0246400</doi><orcidid>https://orcid.org/0000-0002-5848-7929</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2021-02, Vol.16 (2), p.e0246400-e0246400 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adipose tissue Babies Biology and Life Sciences Biomedical research Body composition Body size Breastfeeding & lactation Cell division Children Chromosomes Demographic aspects Deoxyribonucleic acid DNA Editing Endocrinology Funding Gene sequencing Gestational age Health care facilities Infants Leukocytes Measurement Medical research Medicine and Health Sciences Nucleotide sequence Pediatrics People and Places Physiological aspects Protocol (computers) Reviews Telomerase Telomeres Ultrasonic imaging |
| title | Longitudinal telomere length and body composition in healthy term-born infants during the first two years of life |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T23%3A15%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Longitudinal%20telomere%20length%20and%20body%20composition%20in%20healthy%20term-born%20infants%20during%20the%20first%20two%20years%20of%20life&rft.jtitle=PloS%20one&rft.au=de%20Fluiter,%20Kirsten%20S&rft.date=2021-02-02&rft.volume=16&rft.issue=2&rft.spage=e0246400&rft.epage=e0246400&rft.pages=e0246400-e0246400&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0246400&rft_dat=%3Cgale_plos_%3EA650493464%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2485496834&rft_id=info:pmid/33529269&rft_galeid=A650493464&rft_doaj_id=oai_doaj_org_article_5d21de4097164007b61f03b6d9682db8&rfr_iscdi=true |