Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development

SLFN11 has recently been reported to execute cancer cells harboring replicative stress induced by DNA damaging agents. However, the roles of SLFN11 under physiological conditions remain poorly understood. Germinal center B-cells (GCBs) undergo somatic hypermutations and class-switch recombination, w...

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Veröffentlicht in:	PloS one 2021-01, Vol.16 (1), p.e0237554
Hauptverfasser:	Moribe, Fumiya, Nishikori, Momoko, Takashima, Tsuyoshi, Taniyama, Daiki, Onishi, Nobuyuki, Arima, Hiroshi, Sasanuma, Hiroyuki, Akagawa, Remi, Elloumi, Fathi, Takeda, Shunichi, Pommier, Yves, Morii, Eiichi, Takaori-Kondo, Akifumi, Murai, Junko
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis B cells B-Lymphocytes - immunology Biology and Life Sciences Cancer Cell differentiation Cell Line, Tumor Cytarabine Cytosine Databases, Genetic Deamination Deoxyribonucleic acid Development and progression DNA DNA biosynthesis DNA damage Epigenesis, Genetic - drug effects Epigenetic inheritance Epigenetics Epigenomics Ethanol Gene expression Gene Expression - genetics Gene Expression Regulation, Neoplastic - genetics Genetic aspects Genotoxicity Germinal Center - immunology Germinal centers Growth Health aspects Hematology Histone Deacetylase Inhibitors - pharmacology Histone methyltransferase Histones Humans Laboratories Lymphocyte Activation - drug effects Lymphocytes - immunology Lymphocytes B Lymphoma Lymphoma, Large B-Cell, Diffuse - pathology Lymphomas Medical research Medicine Medicine and Health Sciences Nuclear Proteins - genetics Nuclear Proteins - metabolism Oncology Pathology Physiological aspects Plasma Cells - immunology Proto-Oncogene Proteins c-bcl-6 - genetics Research and Analysis Methods Risk factors
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