Adipocyte-induced transdifferentiation of osteoblasts and its potential role in age-related bone loss

Our preliminary findings have lead us to propose bone marrow adipocyte secretions as new contributors to bone loss. Indeed, using a coculture model based on human bone marrow stromal cells, we previously showed that soluble factors secreted by adipocytes induced the conversion of osteoblasts towards...

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Veröffentlicht in:	PloS one 2021-01, Vol.16 (1), p.e0245014-e0245014
Hauptverfasser:	Clabaut, Aline, Grare, Céline, Rolland-Valognes, Gaëlle, Letarouilly, Jean-Guillaume, Bourrier, Chantal, Andersen, Thomas L, Sikjær, Tanja, Rejnmark, Lars, Ejersted, Charlotte, Pastoureau, Philippe, Hardouin, Pierre, Sabatini, Massimo, Broux, Odile
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes - metabolism Adipocytes - physiology Adipose tissue Age Aging Authorship Biology and Life Sciences Biomedical materials Biopsy Bone loss Bone marrow Cell culture Cell Transdifferentiation - physiology Cells, Cultured Clean energy Coculture Techniques Development and progression DNA methylation DNA-directed RNA polymerase Endocrinology Experiments Fat cells Forensic science Gene expression Gene Expression Profiling Genetic aspects Health aspects Human performance Humans Immunohistochemistry Inflammatory diseases Internal medicine Life Sciences Medicine Medicine and Health Sciences Osteoblasts Osteoblasts - metabolism Osteoblasts - physiology Osteoporosis Osteoporosis - genetics Osteoporosis - metabolism Peptidylprolyl isomerase Physiological aspects Polymerase chain reaction Research and Analysis Methods Ribonucleic acid Risk factors RNA RNA polymerase RNA polymerase II Software Statistical analysis Transcriptome Tryptophan Tryptophan 5-monooxygenase Tyrosine Tyrosine 3-monooxygenase
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