Polymorphisms in mitochondrial ribosomal protein S5 (MRPS5) are associated with leprosy risk in Chinese

Leprosy is an infectious disease caused by Mycobacterium leprae (M. leprae), with about 210,000 new cases per year worldwide. Although numerous risk loci have been uncovered by genome-wide association studies, the effects of common genetic variants are relatively modest. To identify possible new gen...

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Veröffentlicht in:	PLoS neglected tropical diseases 2020-12, Vol.14 (12), p.e0008883-e0008883
Hauptverfasser:	Xing, Yan, He, Jun, Wen, Yan, Liu, Jian, You, Yuangang, Weng, Xiaoman, Yuan, Lianchao, Xiong, Li, Chen, Xiaohua, Zhang, Ying, Li, Huan-Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Asian Continental Ancestry Group - genetics Biology and Life Sciences Blood levels Case-Control Studies China - epidemiology Chinese Deformities Deoxyribonucleic acid Disease DNA DNA sequencing Epidemiology Ethics Female Gene expression Gene Expression Regulation Gene sequencing Genetic aspects Genetic Predisposition to Disease Genomes Health aspects Health risks Humans Identification and classification Infectious diseases Leprosy Leprosy - epidemiology Leprosy - genetics Linkage disequilibrium Male Medicine and Health Sciences Middle Aged Mitochondria Mitochondrial Proteins - genetics Mutation Nerves Patients Peripheral nerves Polymerase chain reaction Polymorphism, Single Nucleotide Proteins Research and Analysis Methods Ribosomal protein S5 Ribosomal proteins Ribosomal Proteins - genetics Risk factors Single nucleotide polymorphisms Skin Therapy Tropical diseases Young Adult
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