Phylogenomics of 8,839 Clostridioides difficile genomes reveals recombination-driven evolution and diversification of toxin A and B

Clostridioides difficile is the major worldwide cause of antibiotic-associated gastrointestinal infection. A pathogenicity locus (PaLoc) encoding one or two homologous toxins, toxin A (TcdA) and toxin B (TcdB), is essential for C. difficile pathogenicity. However, toxin sequence variation poses majo...

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Veröffentlicht in:	PLoS pathogens 2020-12, Vol.16 (12), p.e1009181-e1009181
Hauptverfasser:	Mansfield, Michael J, Tremblay, Benjamin J-M, Zeng, Ji, Wei, Xin, Hodgins, Harold, Worley, Jay, Bry, Lynn, Dong, Min, Doxey, Andrew C
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Antibodies Antigenic Variation - genetics Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Toxins - chemistry Bacterial Toxins - genetics Binding Biology and Life Sciences Cell death Clostridioides difficile - classification Clostridioides difficile - genetics Clostridioides difficile - pathogenicity Clostridium difficile Compounds Computer and Information Sciences Cysteine proteinase Cytoskeleton Cytosol Databases, Genetic Diversification Endocytosis Enterotoxins - chemistry Enterotoxins - genetics Epidemics Evolution, Molecular Genetic aspects Genetic Variation Genome, Bacterial - genetics Genomes Glucosyltransferase Health aspects Humans Immunization Immunogenicity Immunology Medical research Medicine and Health Sciences Membranes Models, Molecular Oligopeptides Phylogenetics Phylogeny Protein Conformation Proteins Recombination Recombination, Genetic - physiology Research and Analysis Methods Rounding Sequence Analysis, DNA Toxin A Toxins Translocation Virulence (Microbiology)
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