Epstein-Barr virus LMP1 manipulates the content and functions of extracellular vesicles to enhance metastatic potential of recipient cells

Extracellular vesicles (EV) mediate intercellular communication events and alterations in normal vesicle content contribute to function and disease initiation or progression. The ability to package a variety of cargo and transmit molecular information between cells renders EVs important mediators of...

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Veröffentlicht in:	PLoS pathogens 2020-12, Vol.16 (12), p.e1009023-e1009023
Hauptverfasser:	Nkosi, Dingani, Sun, Li, Duke, Leanne C, Meckes, Jr, David G
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Angiogenesis Antibodies Biological properties Biology and Life Sciences c-Jun protein Cancer Cell adhesion & migration Cell Adhesion - physiology Cell growth Cell Line, Tumor Cell Movement - physiology Cell organelles Cell Proliferation - physiology Cellular signal transduction Communication Development and progression Electron microscopy Epidermal growth factor Epidermal growth factor receptors Epstein-Barr virus Epstein-Barr Virus Infections - metabolism Epstein-Barr Virus Infections - physiopathology Extracellular signal-regulated kinase Extracellular vesicles Extracellular Vesicles - metabolism Extracellular Vesicles - virology Gene expression Genetic aspects Genetic engineering Growth factors Health aspects Herpesvirus 4, Human - genetics Herpesvirus 4, Human - metabolism Herpesvirus 4, Human - pathogenicity Host-virus relationships Humans JNK protein Kinases MAP kinase Medicine and Health Sciences Metastases Metastasis MicroRNAs - metabolism Microscopy Nanoparticles Nasopharyngeal Carcinoma - metabolism Nasopharyngeal Neoplasms - virology Neoplasm Invasiveness - genetics NF-κB protein Phenotypes Polyethylene glycol Protein kinase Proteins Proteomics Receptors Signal Transduction Size exclusion chromatography Stat3 protein Sucrose Sugar Throat cancer TOR protein Transcription factors Tumor Microenvironment Tumorigenesis Ultracentrifugation Vesicles Viral Matrix Proteins - metabolism Viral Matrix Proteins - physiology Viral proteins Viruses
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