Transcriptional analysis of immune response genes during pathogenesis of cytomegalovirus retinitis in mice with murine acquired immunodeficiency syndrome

Human cytomegalovirus (HCMV) is an opportunistic human herpesvirus that causes a sight-threatening retinitis in immunosuppressed patients, especially those with AIDS. Using an established model of experimental murine cytomegalovirus (MCMV) retinitis in mice with retrovirus-induced immunodeficiency (...

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Veröffentlicht in:	PLoS pathogens 2020-11, Vol.16 (11), p.e1009032-e1009032
Hauptverfasser:	Carter, Jessica J, Gardner, Jesse M, Poling, Brent P, Welch, Madeline M, Nemeno, Judee Grace E, Houghton, John E, Dix, Richard D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adaptive immunity AIDS Animals Apoptosis Biology and Life Sciences Cell death Cluster analysis Clustering Cytokines Cytomegalovirus Cytomegalovirus - immunology Cytomegalovirus infections Cytomegalovirus Retinitis - immunology Cytomegalovirus Retinitis - virology Development and progression Disease Models, Animal Eye Eye (anatomy) Eye - immunology Eye - virology Female Gene expression Gene Expression Profiling Genes Genetic aspects Health aspects HIV HIV Infections - immunology HIV Infections - virology Human immunodeficiency virus Humans Immune response Immune system Immunity - genetics Immunodeficiency Immunologic deficiency syndromes Immunology Immunosuppression Immunosuppression Therapy Infections Medicine and Health Sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Murine Acquired Immunodeficiency Syndrome - immunology Murine Acquired Immunodeficiency Syndrome - virology Muromegalovirus - immunology Necrosis Pathogenesis Research and Analysis Methods Retina Retinitis Thickness Transcription Transcription (Genetics) Viruses
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