Context-specific network modeling identifies new crosstalk in β-adrenergic cardiac hypertrophy

Cardiac hypertrophy is a context-dependent phenomenon wherein a myriad of biochemical and biomechanical factors regulate myocardial growth through a complex large-scale signaling network. Although numerous studies have investigated hypertrophic signaling pathways, less is known about hypertrophy sig...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS computational biology 2020-12, Vol.16 (12), p.e1008490-e1008490
Hauptverfasser:	Khalilimeybodi, Ali, Paap, Alexander M, Christiansen, Steven L M, Saucerman, Jeffrey J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Automation Biology and Life Sciences Boolean algebra Cardiomegaly - metabolism Cardiomyocytes Cells, Cultured Computer and Information Sciences Computer Simulation Context Crosstalk Forkhead protein Gene deletion Gene expression Heart Hypertrophy Knowledge Laboratory animals Medicine and Health Sciences Modelling Myocytes Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Ordinary differential equations Phosphorylation Rats Rats, Sprague-Dawley Receptors, Adrenergic, beta - metabolism Sensitivity analysis Signal Transduction Signaling
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!