Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum

Malaria continues to impose a significant health burden in the continent of Africa with 213 million cases in 2018 alone, representing 93% of cases worldwide. Because of high transmission of malaria within the continent, the selection pressures to develop drug resistance in African parasites are dist...

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Veröffentlicht in:	PLoS genetics 2020-12, Vol.16 (12), p.e1009266-e1009266
Hauptverfasser:	Sharma, Aabha I, Shin, Sara H, Bopp, Selina, Volkman, Sarah K, Hartl, Daniel L, Wirth, Dyann F
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials - pharmacology Artemisinin Artemisinins - pharmacology Biology and Life Sciences Cloning CRISPR Distribution Drug Resistance Drug therapy Engineering and Technology Gene mutations Genetic aspects Genetic Background Genomes Health aspects Hemoglobin Kelch Repeat Laboratories Malaria Medicine and Health Sciences Microfilament Proteins - chemistry Microfilament Proteins - genetics Mutants Mutation Parasites Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Prevention Proteins Protozoan Proteins - chemistry Protozoan Proteins - genetics Research and Analysis Methods Survival Whole genome sequencing
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