Ash1 and Tup1 dependent repression of the Saccharomyces cerevisiae HO promoter requires activator-dependent nucleosome eviction

Transcriptional regulation of the Saccharomyces cerevisiae HO gene is highly complex, requiring a balance of multiple activating and repressing factors to ensure that only a few transcripts are produced in mother cells within a narrow window of the cell cycle. Here, we show that the Ash1 repressor a...

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Veröffentlicht in:	PLoS genetics 2020-12, Vol.16 (12), p.e1009133-e1009133
Hauptverfasser:	Parnell, Emily J, Parnell, Timothy J, Yan, Chao, Bai, Lu, Stillman, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Athletic recruitment Binding sites Biology and Life Sciences Brewer's yeast Cell cycle Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Control Deoxyribonucleases, Type II Site-Specific - genetics Deoxyribonucleases, Type II Site-Specific - metabolism Deoxyribonucleic acid DNA DNA-binding protein DNA-directed RNA polymerase Evictions Gene Expression Regulation, Fungal Genetic aspects Genetic engineering Genomes Histone Deacetylases - genetics Histone Deacetylases - metabolism Histones Nuclear Proteins - genetics Nuclear Proteins - metabolism Nucleosomes Nucleosomes - metabolism Nucleotide sequence Physiological aspects Promoter Regions, Genetic Promoters (Genetics) Protein Binding Proteins Repressor proteins Repressor Proteins - genetics Repressor Proteins - metabolism Research and Analysis Methods RNA polymerase Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Transcription Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation Yeast
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