An osteocalcin-deficient mouse strain without endocrine abnormalities

Osteocalcin (OCN), the most abundant noncollagenous protein in the bone matrix, is reported to be a bone-derived endocrine hormone with wide-ranging effects on many aspects of physiology, including glucose metabolism and male fertility. Many of these observations were made using an OCN-deficient mou...

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Veröffentlicht in:	PLoS genetics 2020-05, Vol.16 (5), p.e1008361-e1008361
Hauptverfasser:	Diegel, Cassandra R, Hann, Steven, Ayturk, Ugur M, Hu, Jennifer C W, Lim, Kyung-Eun, Droscha, Casey J, Madaj, Zachary B, Foxa, Gabrielle E, Izaguirre, Isaac, Transgenics Core, Vai Vivarium And, Paracha, Noorulain, Pidhaynyy, Bohdan, Dowd, Terry L, Robling, Alexander G, Warman, Matthew L, Williams, Bart O
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino acids Animals Biological activity Biology and Life Sciences Biomechanics Bone and Bones - metabolism Bone Density - genetics Bone mass Cell number Cognition Composition CRISPR Endocrine system Endocrine System - metabolism Endocrine System - physiology Female Fertility Fertility - genetics Genetic aspects Glucose Glucose tolerance Health aspects Insulin Insulin resistance Insulin Resistance - genetics Intolerance Male Mechanical properties Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Knockout Osteoblasts Osteocalcin Osteocalcin - deficiency Osteocalcin - genetics Osteopontin Protein hormones Proteins Research and Analysis Methods Rodents Serum levels Signal peptidase Testosterone
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