The Mediator CDK8-Cyclin C complex modulates Dpp signaling in Drosophila by stimulating Mad-dependent transcription

Dysregulation of CDK8 (Cyclin-Dependent Kinase 8) and its regulatory partner CycC (Cyclin C), two subunits of the conserved Mediator (MED) complex, have been linked to diverse human diseases such as cancer. Thus, it is essential to understand the regulatory network modulating the CDK8-CycC complex i...

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Veröffentlicht in:	PLoS genetics 2020-05, Vol.16 (5), p.e1008832
Hauptverfasser:	Li, Xiao, Liu, Mengmeng, Ren, Xingjie, Loncle, Nicolas, Wang, Qun, Hemba-Waduge, Rajitha-Udakara-Sampath, Yu, Stephen H, Boube, Muriel, Bourbon, Henri-Marc G, Ni, Jian-Quan, Ji, Jun-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences Cell cycle Cell size Cellular signal transduction Cyclin C Cyclin C - genetics Cyclin C - metabolism Cyclin-dependent kinase 8 Cyclin-Dependent Kinase 8 - genetics Cyclin-Dependent Kinase 8 - metabolism Cyclin-dependent kinases DNA-Binding Proteins - metabolism Drosophila Drosophila Proteins - genetics Drosophila Proteins - metabolism Drug delivery Gene expression Gene Expression Regulation, Developmental Genetic aspects Genetic research Haploinsufficiency Health aspects Imaginal Discs - growth & development Imaginal Discs - metabolism Insects Kinases Life Sciences p53 Protein Phase transitions Physiology Protein kinases Proteins Research and Analysis Methods RNA polymerase Signal Transduction Skin cancer Smad protein Stat1 protein Sterol regulatory element-binding protein Structure Transcription (Genetics) Transcription factors Transcription Factors - metabolism Transcription, Genetic Tumorigenesis
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