CEP290 is essential for the initiation of ciliary transition zone assembly

Cilia play critical roles during embryonic development and adult homeostasis. Dysfunction of cilia leads to various human genetic diseases, including many caused by defects in transition zones (TZs), the "gates" of cilia. The evolutionarily conserved TZ component centrosomal protein 290 (C...

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Veröffentlicht in:	PLoS biology 2020-12, Vol.18 (12), p.e3001034-e3001034
Hauptverfasser:	Wu, Zhimao, Pang, Nan, Zhang, Yingying, Chen, Huicheng, Peng, Ying, Fu, Jingyan, Wei, Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Animals Assembly Binding Biology and Life Sciences Carrier Proteins - metabolism Cation Transport Proteins - metabolism Cell Cycle Proteins - metabolism Centrosomes Cilia - genetics Cilia - metabolism Cilia - physiology Cilia and ciliary motion Construction Cytoskeletal Proteins - metabolism Domains Drosophila Drosophila - metabolism Drosophila Proteins - metabolism Drosophila Proteins - physiology Elongation Fluorescence Fruit flies Gametocytes Gating Genetic aspects Genotype & phenotype Green fluorescent protein Growth GTP Phosphohydrolases - metabolism Health aspects Insects Localization Membrane proteins Microscopy Microtubule-Associated Proteins - metabolism Microtubule-Associated Proteins - physiology Motility Mutation Nuclear Proteins - metabolism Olfactory cilia Physiological aspects Proteins Research and Analysis Methods
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