The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins

SARS Coronavirus 2 (SARS-CoV-2) emerged in late 2019, leading to the Coronavirus Disease 2019 (COVID-19) pandemic that continues to cause significant global mortality in human populations. Given its sequence similarity to SARS-CoV, as well as related coronaviruses circulating in bats, SARS-CoV-2 is...

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Veröffentlicht in:	PLoS biology 2020-12, Vol.18 (12), p.e3001016
Hauptverfasser:	Conceicao, Carina, Thakur, Nazia, Human, Stacey, Kelly, James T, Logan, Leanne, Bialy, Dagmara, Bhat, Sushant, Stevenson-Leggett, Phoebe, Zagrajek, Adrian K, Hollinghurst, Philippa, Varga, Michal, Tsirigoti, Christina, Tully, Matthew, Chiu, Chris, Moffat, Katy, Silesian, Adrian Paul, Hammond, John A, Maier, Helena J, Bickerton, Erica, Shelton, Holly, Dietrich, Isabelle, Graham, Stephen C, Bailey, Dalan
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Amino acid sequence Amino Acid Substitution Amino acids Angiotensin converting enzyme Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - metabolism Animals Binding Sites Biology and life sciences Cats Cattle Conserved sequence Coronaviruses COVID-19 Divergence Dogs Flight Genetic aspects Goats Guinea Pigs Hamsters Health aspects HEK293 Cells Horses Host-Pathogen Interactions Host-virus relationships Humans Identification and classification Livestock Mammals Medicine and health sciences Middle East respiratory syndrome Phylogeny Physiological aspects Proteins Rabbits Rats Research and Analysis Methods SARS-CoV-2 - physiology Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Sheep Species Spike Glycoprotein, Coronavirus - metabolism Spike protein Tropism Tropisms Vertebrates Viral diseases Viral Tropism Viral Zoonoses - virology Virus Attachment Zoonoses
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