Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides

Microbial natural products constitute a wide variety of chemical compounds, many which can have antibiotic, antiviral, or anticancer properties that make them interesting for clinical purposes. Natural product classes include polyketides (PKs), nonribosomal peptides (NRPs), and ribosomally synthesiz...

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Veröffentlicht in:PLoS biology 2020-12, Vol.18 (12), p.e3001026-e3001026
Hauptverfasser: Kloosterman, Alexander M, Cimermancic, Peter, Elsayed, Somayah S, Du, Chao, Hadjithomas, Michalis, Donia, Mohamed S, Fischbach, Michael A, van Wezel, Gilles P, Medema, Marnix H
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Sprache:eng
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