Hmx1 regulates urfh1 expression in the craniofacial region in zebrafish
H6 family homeobox 1 (HMX1) regulates multiple aspects of craniofacial development as it is widely expressed in the eye, peripheral ganglia and branchial arches. Mutations in HMX1 are linked to an ocular defect termed Oculo-auricular syndrome of Schorderet-Munier-Franceschetti (MIM #612109). We iden...
Gespeichert in:
| Veröffentlicht in: | PloS one 2021-01, Vol.16 (1), p.e0245239-e0245239 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0245239 |
|---|---|
| container_issue | 1 |
| container_start_page | e0245239 |
| container_title | PloS one |
| container_volume | 16 |
| creator | El Fersioui, Younes Pinton, Gaëtan Allaman-Pillet, Nathalie Schorderet, Daniel F |
| description | H6 family homeobox 1 (HMX1) regulates multiple aspects of craniofacial development as it is widely expressed in the eye, peripheral ganglia and branchial arches. Mutations in HMX1 are linked to an ocular defect termed Oculo-auricular syndrome of Schorderet-Munier-Franceschetti (MIM #612109). We identified UHRF1 as a target of HMX1 during development. UHRF1 and its partner proteins actively regulate chromatin modifications and cellular proliferation. Luciferase assays and in situ hybridization analyses showed that HMX1 exerts a transcriptional inhibitory effect on UHRF1 and a modification of its expression pattern. Overexpression of hmx1 in hsp70-hmx1 zebrafish increased uhrf1 expression in the cranial region, while mutations in the hmx1 dimerization domains reduced uhrf1 expression. Moreover, the expression level of uhrf1 and its partner dnmt1 was increased in the eye field in response to hmx1 overexpression. These results indicate that hmx1 regulates uhrf1 expression and, potentially through regulating the expression of factors involved in DNA methylation, contribute to the development of the craniofacial region of zebrafish. |
| doi_str_mv | 10.1371/journal.pone.0245239 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2479032539</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A649078827</galeid><doaj_id>oai_doaj_org_article_79b113966279455ea85dc416e0d25ce9</doaj_id><sourcerecordid>A649078827</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-92af5b65043170b27e4d681d393f53a9ad735de36f2ac27225da8bed6680ee113</originalsourceid><addsrcrecordid>eNqNkl1r2zAUhs3YWNts_2BshkHZLpLpw5Ktm0EpWxsoFPZ1K2TpOFZQrFSyR7ZfP2VxSzx6MXQhcc5z3iMdvVn2CqMFpiX-sPZD6JRbbH0HC0QKRqh4kp1iQcmcE0SfHp1PsrMY1wgxWnH-PDuhtOAMY3SaXV1vdjgPsBqc6iHmQ2hanMNuGyBG67vcdnnfQq6D6qxvlLbK7fEx9RvqoBob2xfZs0a5CC_HfZZ9__zp2-X1_Ob2anl5cTPXXJB-LohqWM0ZKiguUU1KKAyvsKGCNowqoUxJmQHKG6I0KQlhRlU1GM4rBIAxnWVvDrpb56McZxAlKUqBKGFJZ5YtD4Txai23wW5U-CW9svJvwIeVVKG32oEsRZ0kBeekFAVjoCpmdIE5IEOYhr3Wx7HbUG_AaOj6oNxEdJrpbCtX_qcsK5zmWyWBd6NA8HcDxF5ubNTgnOrAD4d7F4QWGCX07T_o468bqZVKD7Bd41NfvReVF7wQqKwqUiZq8QiVloGN1ckwjU3xScH7SUFietj1KzXEKJdfv_w_e_tjyp4fsS0o17fRu6FP_olTsDiAOvgYAzQPQ8ZI7v1-Pw2597sc_Z7KXh9_0EPRvcHpH1Hh-OU</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2479032539</pqid></control><display><type>article</type><title>Hmx1 regulates urfh1 expression in the craniofacial region in zebrafish</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS)</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>El Fersioui, Younes ; Pinton, Gaëtan ; Allaman-Pillet, Nathalie ; Schorderet, Daniel F</creator><contributor>Schubert, Michael</contributor><creatorcontrib>El Fersioui, Younes ; Pinton, Gaëtan ; Allaman-Pillet, Nathalie ; Schorderet, Daniel F ; Schubert, Michael</creatorcontrib><description>H6 family homeobox 1 (HMX1) regulates multiple aspects of craniofacial development as it is widely expressed in the eye, peripheral ganglia and branchial arches. Mutations in HMX1 are linked to an ocular defect termed Oculo-auricular syndrome of Schorderet-Munier-Franceschetti (MIM #612109). We identified UHRF1 as a target of HMX1 during development. UHRF1 and its partner proteins actively regulate chromatin modifications and cellular proliferation. Luciferase assays and in situ hybridization analyses showed that HMX1 exerts a transcriptional inhibitory effect on UHRF1 and a modification of its expression pattern. Overexpression of hmx1 in hsp70-hmx1 zebrafish increased uhrf1 expression in the cranial region, while mutations in the hmx1 dimerization domains reduced uhrf1 expression. Moreover, the expression level of uhrf1 and its partner dnmt1 was increased in the eye field in response to hmx1 overexpression. These results indicate that hmx1 regulates uhrf1 expression and, potentially through regulating the expression of factors involved in DNA methylation, contribute to the development of the craniofacial region of zebrafish.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0245239</identifier><identifier>PMID: 33465110</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Binding sites ; Biology and Life Sciences ; Cell cycle ; Cell division ; Cell migration ; Danio rerio ; Deoxyribonucleic acid ; Developmental stages ; DNA ; DNA binding proteins ; DNA methylation ; DNMT1 protein ; Editing ; Electronic mail ; Embryogenesis ; Embryonic development ; Embryonic growth stage ; Embryos ; Epigenetics ; Experiments ; Face ; Gene expression ; Genetic aspects ; Genetic research ; Heat shock ; Hindbrain ; Homeobox genes ; Homeotic genes ; Hybridization ; Intestine ; Mammalian cells ; Medicine and Health Sciences ; Mutation ; Neural crest ; Neural tube ; Ophthalmology ; Physiological aspects ; Research and Analysis Methods ; Retina ; Reviews ; Transcription ; Transcription factors ; Transfection ; Vertebrates ; Zebra fish ; Zebrafish</subject><ispartof>PloS one, 2021-01, Vol.16 (1), p.e0245239-e0245239</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 El Fersioui et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 El Fersioui et al 2021 El Fersioui et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-92af5b65043170b27e4d681d393f53a9ad735de36f2ac27225da8bed6680ee113</citedby><cites>FETCH-LOGICAL-c692t-92af5b65043170b27e4d681d393f53a9ad735de36f2ac27225da8bed6680ee113</cites><orcidid>0000-0002-6064-927X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815118/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815118/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33465110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Schubert, Michael</contributor><creatorcontrib>El Fersioui, Younes</creatorcontrib><creatorcontrib>Pinton, Gaëtan</creatorcontrib><creatorcontrib>Allaman-Pillet, Nathalie</creatorcontrib><creatorcontrib>Schorderet, Daniel F</creatorcontrib><title>Hmx1 regulates urfh1 expression in the craniofacial region in zebrafish</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>H6 family homeobox 1 (HMX1) regulates multiple aspects of craniofacial development as it is widely expressed in the eye, peripheral ganglia and branchial arches. Mutations in HMX1 are linked to an ocular defect termed Oculo-auricular syndrome of Schorderet-Munier-Franceschetti (MIM #612109). We identified UHRF1 as a target of HMX1 during development. UHRF1 and its partner proteins actively regulate chromatin modifications and cellular proliferation. Luciferase assays and in situ hybridization analyses showed that HMX1 exerts a transcriptional inhibitory effect on UHRF1 and a modification of its expression pattern. Overexpression of hmx1 in hsp70-hmx1 zebrafish increased uhrf1 expression in the cranial region, while mutations in the hmx1 dimerization domains reduced uhrf1 expression. Moreover, the expression level of uhrf1 and its partner dnmt1 was increased in the eye field in response to hmx1 overexpression. These results indicate that hmx1 regulates uhrf1 expression and, potentially through regulating the expression of factors involved in DNA methylation, contribute to the development of the craniofacial region of zebrafish.</description><subject>Binding sites</subject><subject>Biology and Life Sciences</subject><subject>Cell cycle</subject><subject>Cell division</subject><subject>Cell migration</subject><subject>Danio rerio</subject><subject>Deoxyribonucleic acid</subject><subject>Developmental stages</subject><subject>DNA</subject><subject>DNA binding proteins</subject><subject>DNA methylation</subject><subject>DNMT1 protein</subject><subject>Editing</subject><subject>Electronic mail</subject><subject>Embryogenesis</subject><subject>Embryonic development</subject><subject>Embryonic growth stage</subject><subject>Embryos</subject><subject>Epigenetics</subject><subject>Experiments</subject><subject>Face</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Genetic research</subject><subject>Heat shock</subject><subject>Hindbrain</subject><subject>Homeobox genes</subject><subject>Homeotic genes</subject><subject>Hybridization</subject><subject>Intestine</subject><subject>Mammalian cells</subject><subject>Medicine and Health Sciences</subject><subject>Mutation</subject><subject>Neural crest</subject><subject>Neural tube</subject><subject>Ophthalmology</subject><subject>Physiological aspects</subject><subject>Research and Analysis Methods</subject><subject>Retina</subject><subject>Reviews</subject><subject>Transcription</subject><subject>Transcription factors</subject><subject>Transfection</subject><subject>Vertebrates</subject><subject>Zebra fish</subject><subject>Zebrafish</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1r2zAUhs3YWNts_2BshkHZLpLpw5Ktm0EpWxsoFPZ1K2TpOFZQrFSyR7ZfP2VxSzx6MXQhcc5z3iMdvVn2CqMFpiX-sPZD6JRbbH0HC0QKRqh4kp1iQcmcE0SfHp1PsrMY1wgxWnH-PDuhtOAMY3SaXV1vdjgPsBqc6iHmQ2hanMNuGyBG67vcdnnfQq6D6qxvlLbK7fEx9RvqoBob2xfZs0a5CC_HfZZ9__zp2-X1_Ob2anl5cTPXXJB-LohqWM0ZKiguUU1KKAyvsKGCNowqoUxJmQHKG6I0KQlhRlU1GM4rBIAxnWVvDrpb56McZxAlKUqBKGFJZ5YtD4Txai23wW5U-CW9svJvwIeVVKG32oEsRZ0kBeekFAVjoCpmdIE5IEOYhr3Wx7HbUG_AaOj6oNxEdJrpbCtX_qcsK5zmWyWBd6NA8HcDxF5ubNTgnOrAD4d7F4QWGCX07T_o468bqZVKD7Bd41NfvReVF7wQqKwqUiZq8QiVloGN1ckwjU3xScH7SUFietj1KzXEKJdfv_w_e_tjyp4fsS0o17fRu6FP_olTsDiAOvgYAzQPQ8ZI7v1-Pw2597sc_Z7KXh9_0EPRvcHpH1Hh-OU</recordid><startdate>20210119</startdate><enddate>20210119</enddate><creator>El Fersioui, Younes</creator><creator>Pinton, Gaëtan</creator><creator>Allaman-Pillet, Nathalie</creator><creator>Schorderet, Daniel F</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6064-927X</orcidid></search><sort><creationdate>20210119</creationdate><title>Hmx1 regulates urfh1 expression in the craniofacial region in zebrafish</title><author>El Fersioui, Younes ; Pinton, Gaëtan ; Allaman-Pillet, Nathalie ; Schorderet, Daniel F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-92af5b65043170b27e4d681d393f53a9ad735de36f2ac27225da8bed6680ee113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Binding sites</topic><topic>Biology and Life Sciences</topic><topic>Cell cycle</topic><topic>Cell division</topic><topic>Cell migration</topic><topic>Danio rerio</topic><topic>Deoxyribonucleic acid</topic><topic>Developmental stages</topic><topic>DNA</topic><topic>DNA binding proteins</topic><topic>DNA methylation</topic><topic>DNMT1 protein</topic><topic>Editing</topic><topic>Electronic mail</topic><topic>Embryogenesis</topic><topic>Embryonic development</topic><topic>Embryonic growth stage</topic><topic>Embryos</topic><topic>Epigenetics</topic><topic>Experiments</topic><topic>Face</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Genetic research</topic><topic>Heat shock</topic><topic>Hindbrain</topic><topic>Homeobox genes</topic><topic>Homeotic genes</topic><topic>Hybridization</topic><topic>Intestine</topic><topic>Mammalian cells</topic><topic>Medicine and Health Sciences</topic><topic>Mutation</topic><topic>Neural crest</topic><topic>Neural tube</topic><topic>Ophthalmology</topic><topic>Physiological aspects</topic><topic>Research and Analysis Methods</topic><topic>Retina</topic><topic>Reviews</topic><topic>Transcription</topic><topic>Transcription factors</topic><topic>Transfection</topic><topic>Vertebrates</topic><topic>Zebra fish</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El Fersioui, Younes</creatorcontrib><creatorcontrib>Pinton, Gaëtan</creatorcontrib><creatorcontrib>Allaman-Pillet, Nathalie</creatorcontrib><creatorcontrib>Schorderet, Daniel F</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El Fersioui, Younes</au><au>Pinton, Gaëtan</au><au>Allaman-Pillet, Nathalie</au><au>Schorderet, Daniel F</au><au>Schubert, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hmx1 regulates urfh1 expression in the craniofacial region in zebrafish</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-01-19</date><risdate>2021</risdate><volume>16</volume><issue>1</issue><spage>e0245239</spage><epage>e0245239</epage><pages>e0245239-e0245239</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>H6 family homeobox 1 (HMX1) regulates multiple aspects of craniofacial development as it is widely expressed in the eye, peripheral ganglia and branchial arches. Mutations in HMX1 are linked to an ocular defect termed Oculo-auricular syndrome of Schorderet-Munier-Franceschetti (MIM #612109). We identified UHRF1 as a target of HMX1 during development. UHRF1 and its partner proteins actively regulate chromatin modifications and cellular proliferation. Luciferase assays and in situ hybridization analyses showed that HMX1 exerts a transcriptional inhibitory effect on UHRF1 and a modification of its expression pattern. Overexpression of hmx1 in hsp70-hmx1 zebrafish increased uhrf1 expression in the cranial region, while mutations in the hmx1 dimerization domains reduced uhrf1 expression. Moreover, the expression level of uhrf1 and its partner dnmt1 was increased in the eye field in response to hmx1 overexpression. These results indicate that hmx1 regulates uhrf1 expression and, potentially through regulating the expression of factors involved in DNA methylation, contribute to the development of the craniofacial region of zebrafish.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33465110</pmid><doi>10.1371/journal.pone.0245239</doi><tpages>e0245239</tpages><orcidid>https://orcid.org/0000-0002-6064-927X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2021-01, Vol.16 (1), p.e0245239-e0245239 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2479032539 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Binding sites Biology and Life Sciences Cell cycle Cell division Cell migration Danio rerio Deoxyribonucleic acid Developmental stages DNA DNA binding proteins DNA methylation DNMT1 protein Editing Electronic mail Embryogenesis Embryonic development Embryonic growth stage Embryos Epigenetics Experiments Face Gene expression Genetic aspects Genetic research Heat shock Hindbrain Homeobox genes Homeotic genes Hybridization Intestine Mammalian cells Medicine and Health Sciences Mutation Neural crest Neural tube Ophthalmology Physiological aspects Research and Analysis Methods Retina Reviews Transcription Transcription factors Transfection Vertebrates Zebra fish Zebrafish |
| title | Hmx1 regulates urfh1 expression in the craniofacial region in zebrafish |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T22%3A30%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hmx1%20regulates%20urfh1%20expression%20in%20the%20craniofacial%20region%20in%20zebrafish&rft.jtitle=PloS%20one&rft.au=El%20Fersioui,%20Younes&rft.date=2021-01-19&rft.volume=16&rft.issue=1&rft.spage=e0245239&rft.epage=e0245239&rft.pages=e0245239-e0245239&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0245239&rft_dat=%3Cgale_plos_%3EA649078827%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2479032539&rft_id=info:pmid/33465110&rft_galeid=A649078827&rft_doaj_id=oai_doaj_org_article_79b113966279455ea85dc416e0d25ce9&rfr_iscdi=true |