Characteristics and etiologies of hepatocellular carcinoma in patients without cirrhosis: When East meets West
A recent study from the United States reported that nearly 12% of hepatocellular carcinomas (HCCs) occurred in patients without cirrhosis. Non-alcoholic fatty liver disease (NAFLD) was the most common liver disease in these patients. We aim to evaluate the characteristics, etiologies, and outcomes o...
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| description | A recent study from the United States reported that nearly 12% of hepatocellular carcinomas (HCCs) occurred in patients without cirrhosis. Non-alcoholic fatty liver disease (NAFLD) was the most common liver disease in these patients. We aim to evaluate the characteristics, etiologies, and outcomes of cases of non-cirrhotic HCC in East Asia, where there is a higher prevalence of hepatitis B virus (HBV)-associated non-cirrhotic HCC.
This retrospective study consecutively enrolled de novo HCC patients managed at our institution from 2011 to 2017. The presence of cirrhosis was assessed by histology; if histology was not available, it was assessed by image study.
2055 patients with HCC were enrolled in this study. Among them, 529 (25.7%) were non-cirrhotic. The non-cirrhotic patients were younger (60.9 vs. 62.5 years, p = 0.006), included a greater proportion of males (78.1% vs. 71.3%, p = 0.002), and had a lower body mass index (24.3 vs. 25.3 kg/m2, p |
| doi_str_mv | 10.1371/journal.pone.0244939 |
| format | Article |
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This retrospective study consecutively enrolled de novo HCC patients managed at our institution from 2011 to 2017. The presence of cirrhosis was assessed by histology; if histology was not available, it was assessed by image study.
2055 patients with HCC were enrolled in this study. Among them, 529 (25.7%) were non-cirrhotic. The non-cirrhotic patients were younger (60.9 vs. 62.5 years, p = 0.006), included a greater proportion of males (78.1% vs. 71.3%, p = 0.002), and had a lower body mass index (24.3 vs. 25.3 kg/m2, p<0.001) than the cirrhotic patients. Among the non-cirrhotic patients, HBV was the most common liver disease (49.0%). The patients with non-cirrhotic HCC had larger tumors (5.9 vs. 4.7 cm, p<0.001), underwent liver resection at a higher rate (66.0% vs. 17.4%, p<0.001), and had better overall survival than the cirrhotic HCC patients (median 5.67 vs. 2.83 years, p<0.001).
Nearly 26% of the HCCs occurred in patients without cirrhosis. HBV was the most common liver disease in these patients, and the survival was better in the non-cirrhotic patients than the cirrhotic patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0244939</identifier><identifier>PMID: 33439893</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Ablation ; Adult ; Age ; Alcohol ; Biology and life sciences ; Carcinoma, Hepatocellular - complications ; Carcinoma, Hepatocellular - epidemiology ; Carcinoma, Hepatocellular - etiology ; Carcinoma, Hepatocellular - therapy ; Causes of ; Chemoembolization ; Cirrhosis ; Diagnosis ; Diagnostic systems ; Embolization ; Enrollments ; Etiology ; Female ; Hepatitis B ; Hepatocellular carcinoma ; Hepatoma ; Histology ; Hospitals ; Humans ; Internal medicine ; Liver ; Liver cancer ; Liver cirrhosis ; Liver Cirrhosis - complications ; Liver diseases ; Liver Neoplasms - complications ; Liver Neoplasms - epidemiology ; Liver Neoplasms - etiology ; Liver Neoplasms - therapy ; Liver transplantation ; Male ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Mortality ; Patient outcomes ; Patients ; Prevalence ; Radio frequency ; Radiology ; Retrospective Studies ; Surgery ; Surveillance ; Transplantation ; Tumors</subject><ispartof>PloS one, 2021-01, Vol.16 (1), p.e0244939-e0244939</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Yen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Yen et al 2021 Yen et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-3baed3633c216b5785bdff5ab589ab7d001ef386ffdd37f5d5e501b92aaa68ae3</citedby><cites>FETCH-LOGICAL-c692t-3baed3633c216b5785bdff5ab589ab7d001ef386ffdd37f5d5e501b92aaa68ae3</cites><orcidid>0000-0001-6251-7230</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806135/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806135/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33439893$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yen, Yi-Hao</creatorcontrib><creatorcontrib>Cheng, Yu-Fan</creatorcontrib><creatorcontrib>Wang, Jing-Houng</creatorcontrib><creatorcontrib>Lin, Chih-Che</creatorcontrib><creatorcontrib>Wang, Chih-Chi</creatorcontrib><title>Characteristics and etiologies of hepatocellular carcinoma in patients without cirrhosis: When East meets West</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>A recent study from the United States reported that nearly 12% of hepatocellular carcinomas (HCCs) occurred in patients without cirrhosis. Non-alcoholic fatty liver disease (NAFLD) was the most common liver disease in these patients. We aim to evaluate the characteristics, etiologies, and outcomes of cases of non-cirrhotic HCC in East Asia, where there is a higher prevalence of hepatitis B virus (HBV)-associated non-cirrhotic HCC.
This retrospective study consecutively enrolled de novo HCC patients managed at our institution from 2011 to 2017. The presence of cirrhosis was assessed by histology; if histology was not available, it was assessed by image study.
2055 patients with HCC were enrolled in this study. Among them, 529 (25.7%) were non-cirrhotic. The non-cirrhotic patients were younger (60.9 vs. 62.5 years, p = 0.006), included a greater proportion of males (78.1% vs. 71.3%, p = 0.002), and had a lower body mass index (24.3 vs. 25.3 kg/m2, p<0.001) than the cirrhotic patients. Among the non-cirrhotic patients, HBV was the most common liver disease (49.0%). The patients with non-cirrhotic HCC had larger tumors (5.9 vs. 4.7 cm, p<0.001), underwent liver resection at a higher rate (66.0% vs. 17.4%, p<0.001), and had better overall survival than the cirrhotic HCC patients (median 5.67 vs. 2.83 years, p<0.001).
Nearly 26% of the HCCs occurred in patients without cirrhosis. HBV was the most common liver disease in these patients, and the survival was better in the non-cirrhotic patients than the cirrhotic patients.</description><subject>Ablation</subject><subject>Adult</subject><subject>Age</subject><subject>Alcohol</subject><subject>Biology and life sciences</subject><subject>Carcinoma, Hepatocellular - complications</subject><subject>Carcinoma, Hepatocellular - epidemiology</subject><subject>Carcinoma, Hepatocellular - etiology</subject><subject>Carcinoma, Hepatocellular - therapy</subject><subject>Causes of</subject><subject>Chemoembolization</subject><subject>Cirrhosis</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Embolization</subject><subject>Enrollments</subject><subject>Etiology</subject><subject>Female</subject><subject>Hepatitis B</subject><subject>Hepatocellular carcinoma</subject><subject>Hepatoma</subject><subject>Histology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver diseases</subject><subject>Liver Neoplasms - complications</subject><subject>Liver Neoplasms - epidemiology</subject><subject>Liver Neoplasms - etiology</subject><subject>Liver Neoplasms - therapy</subject><subject>Liver transplantation</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Prevalence</subject><subject>Radio frequency</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surveillance</subject><subject>Transplantation</subject><subject>Tumors</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11rFDEUhgdRbK3-A9EBQfRi18xkMh9eCGWpulAo-NXLcJI52UmZSbZJxo9_b7Y7LTvSC8lFQvKc9-S8yUmS5xlZZrTK3l3Z0Rnol1trcEnyomho8yA5zhqaL8qc0IcH66PkifdXhDBal-Xj5IjSgjZ1Q48Ts-rAgQzotA9a-hRMm2LQtrcbjT61Ku1wC8FK7PuxB5dKcFIbO0CqTRpPNJrg0186dHYMqdTOddZr_z697NCkZ-BDOiBG5BJ9eJo8UtB7fDbNJ8n3j2ffVp8X5xef1qvT84UsmzwsqABsaUmpzLNSsKpmolWKgWB1A6JqCclQxVqUaltaKdYyZCQTTQ4AZQ1IT5KXe91tbz2frPI8L6qKNawqaCTWe6K1cMW3Tg_g_nALmt9sWLfh4KIjPfKqxJpWjcglikI0mSDYNgVjqhBV3tYyan2Yso1iwFZGRxz0M9H5idEd39ifvKpJmVEWBd5MAs5ej9EnPmi_cxwM2vHm3jWhjBVlRF_9g95f3URtIBagjbIxr9yJ8tOyqPOYk2SRWt5DxdHioGX8V0rH_VnA21lAZAL-DhsYvefrr1_-n734MWdfH7AdQh86b_sx_kPj52CxB6Wz3jtUdyZnhO_a4tYNvmsLPrVFDHtx-EB3Qbd9QP8Cy5kKRg</recordid><startdate>20210113</startdate><enddate>20210113</enddate><creator>Yen, Yi-Hao</creator><creator>Cheng, Yu-Fan</creator><creator>Wang, Jing-Houng</creator><creator>Lin, Chih-Che</creator><creator>Wang, Chih-Chi</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6251-7230</orcidid></search><sort><creationdate>20210113</creationdate><title>Characteristics and etiologies of hepatocellular carcinoma in patients without cirrhosis: When East meets West</title><author>Yen, Yi-Hao ; Cheng, Yu-Fan ; Wang, Jing-Houng ; Lin, Chih-Che ; Wang, Chih-Chi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-3baed3633c216b5785bdff5ab589ab7d001ef386ffdd37f5d5e501b92aaa68ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Ablation</topic><topic>Adult</topic><topic>Age</topic><topic>Alcohol</topic><topic>Biology and life sciences</topic><topic>Carcinoma, Hepatocellular - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yen, Yi-Hao</au><au>Cheng, Yu-Fan</au><au>Wang, Jing-Houng</au><au>Lin, Chih-Che</au><au>Wang, Chih-Chi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics and etiologies of hepatocellular carcinoma in patients without cirrhosis: When East meets West</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-01-13</date><risdate>2021</risdate><volume>16</volume><issue>1</issue><spage>e0244939</spage><epage>e0244939</epage><pages>e0244939-e0244939</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>A recent study from the United States reported that nearly 12% of hepatocellular carcinomas (HCCs) occurred in patients without cirrhosis. Non-alcoholic fatty liver disease (NAFLD) was the most common liver disease in these patients. We aim to evaluate the characteristics, etiologies, and outcomes of cases of non-cirrhotic HCC in East Asia, where there is a higher prevalence of hepatitis B virus (HBV)-associated non-cirrhotic HCC.
This retrospective study consecutively enrolled de novo HCC patients managed at our institution from 2011 to 2017. The presence of cirrhosis was assessed by histology; if histology was not available, it was assessed by image study.
2055 patients with HCC were enrolled in this study. Among them, 529 (25.7%) were non-cirrhotic. The non-cirrhotic patients were younger (60.9 vs. 62.5 years, p = 0.006), included a greater proportion of males (78.1% vs. 71.3%, p = 0.002), and had a lower body mass index (24.3 vs. 25.3 kg/m2, p<0.001) than the cirrhotic patients. Among the non-cirrhotic patients, HBV was the most common liver disease (49.0%). The patients with non-cirrhotic HCC had larger tumors (5.9 vs. 4.7 cm, p<0.001), underwent liver resection at a higher rate (66.0% vs. 17.4%, p<0.001), and had better overall survival than the cirrhotic HCC patients (median 5.67 vs. 2.83 years, p<0.001).
Nearly 26% of the HCCs occurred in patients without cirrhosis. HBV was the most common liver disease in these patients, and the survival was better in the non-cirrhotic patients than the cirrhotic patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33439893</pmid><doi>10.1371/journal.pone.0244939</doi><tpages>e0244939</tpages><orcidid>https://orcid.org/0000-0001-6251-7230</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Ablation Adult Age Alcohol Biology and life sciences Carcinoma, Hepatocellular - complications Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - therapy Causes of Chemoembolization Cirrhosis Diagnosis Diagnostic systems Embolization Enrollments Etiology Female Hepatitis B Hepatocellular carcinoma Hepatoma Histology Hospitals Humans Internal medicine Liver Liver cancer Liver cirrhosis Liver Cirrhosis - complications Liver diseases Liver Neoplasms - complications Liver Neoplasms - epidemiology Liver Neoplasms - etiology Liver Neoplasms - therapy Liver transplantation Male Medicine Medicine and Health Sciences Middle Aged Mortality Patient outcomes Patients Prevalence Radio frequency Radiology Retrospective Studies Surgery Surveillance Transplantation Tumors |
| title | Characteristics and etiologies of hepatocellular carcinoma in patients without cirrhosis: When East meets West |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T12%3A39%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Characteristics%20and%20etiologies%20of%20hepatocellular%20carcinoma%20in%20patients%20without%20cirrhosis:%20When%20East%20meets%20West&rft.jtitle=PloS%20one&rft.au=Yen,%20Yi-Hao&rft.date=2021-01-13&rft.volume=16&rft.issue=1&rft.spage=e0244939&rft.epage=e0244939&rft.pages=e0244939-e0244939&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0244939&rft_dat=%3Cgale_plos_%3EA648235301%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2477595743&rft_id=info:pmid/33439893&rft_galeid=A648235301&rft_doaj_id=oai_doaj_org_article_76e8379b2ceb4b91b0ed9455f4b72d8c&rfr_iscdi=true |