Utilization of the Naranjo scale to evaluate adverse drug reactions at a free-standing children's hospital
The relationship between the Naranjo scaling system and pediatric adverse drug reactions (ADR) is poorly understood. We performed a retrospective review of 1,676 pediatric ADRs documented at our hospital from 2014-2018. We evaluated patient demographics, implicated medication, ADR severity, calculat...
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| description | The relationship between the Naranjo scaling system and pediatric adverse drug reactions (ADR) is poorly understood. We performed a retrospective review of 1,676 pediatric ADRs documented at our hospital from 2014-2018. We evaluated patient demographics, implicated medication, ADR severity, calculated Naranjo score, associated symptoms, and location within the hospital in which the ADR was documented. ADR severity was poorly correlated with Naranjo interpretation. Out of the 10 Naranjo scale questions, 4 had a response of "unknown" greater than 85% of the time. Cardiovascular and oncological/immunologic agents were more likely to have a probable or definite Naranjo interpretation compared to antimicrobials. Further strategies are needed to enhance the causality assessment of pediatric ADRs in clinical care. |
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We performed a retrospective review of 1,676 pediatric ADRs documented at our hospital from 2014-2018. We evaluated patient demographics, implicated medication, ADR severity, calculated Naranjo score, associated symptoms, and location within the hospital in which the ADR was documented. ADR severity was poorly correlated with Naranjo interpretation. Out of the 10 Naranjo scale questions, 4 had a response of "unknown" greater than 85% of the time. Cardiovascular and oncological/immunologic agents were more likely to have a probable or definite Naranjo interpretation compared to antimicrobials. Further strategies are needed to enhance the causality assessment of pediatric ADRs in clinical care.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0245368</identifier><identifier>PMID: 33439905</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adverse and side effects ; Age ; Biology and Life Sciences ; Children's hospitals ; Computer and Information Sciences ; Demographics ; Demography ; Drugs ; Electronic health records ; Electronic medical records ; Ethnicity ; Genotype & phenotype ; Hospitalization ; Mathematical analysis ; Medical records ; Medicine and Health Sciences ; Monte Carlo simulation ; Pediatric research ; Pediatrics ; People and Places ; Pharmacovigilance ; Phenotypes ; Quality management ; Questionnaires ; Questions ; Side effects</subject><ispartof>PloS one, 2021-01, Vol.16 (1), p.e0245368-e0245368</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Murali et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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We performed a retrospective review of 1,676 pediatric ADRs documented at our hospital from 2014-2018. We evaluated patient demographics, implicated medication, ADR severity, calculated Naranjo score, associated symptoms, and location within the hospital in which the ADR was documented. ADR severity was poorly correlated with Naranjo interpretation. Out of the 10 Naranjo scale questions, 4 had a response of "unknown" greater than 85% of the time. Cardiovascular and oncological/immunologic agents were more likely to have a probable or definite Naranjo interpretation compared to antimicrobials. 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Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murali, Madhavi</au><au>Suppes, Sarah L</au><au>Feldman, Keith</au><au>Goldman, Jennifer L</au><au>Schaiquevich, Paula</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Utilization of the Naranjo scale to evaluate adverse drug reactions at a free-standing children's hospital</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-01-13</date><risdate>2021</risdate><volume>16</volume><issue>1</issue><spage>e0245368</spage><epage>e0245368</epage><pages>e0245368-e0245368</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The relationship between the Naranjo scaling system and pediatric adverse drug reactions (ADR) is poorly understood. We performed a retrospective review of 1,676 pediatric ADRs documented at our hospital from 2014-2018. We evaluated patient demographics, implicated medication, ADR severity, calculated Naranjo score, associated symptoms, and location within the hospital in which the ADR was documented. ADR severity was poorly correlated with Naranjo interpretation. Out of the 10 Naranjo scale questions, 4 had a response of "unknown" greater than 85% of the time. Cardiovascular and oncological/immunologic agents were more likely to have a probable or definite Naranjo interpretation compared to antimicrobials. Further strategies are needed to enhance the causality assessment of pediatric ADRs in clinical care.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33439905</pmid><doi>10.1371/journal.pone.0245368</doi><tpages>e0245368</tpages><orcidid>https://orcid.org/0000-0001-6628-8949</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adverse and side effects Age Biology and Life Sciences Children's hospitals Computer and Information Sciences Demographics Demography Drugs Electronic health records Electronic medical records Ethnicity Genotype & phenotype Hospitalization Mathematical analysis Medical records Medicine and Health Sciences Monte Carlo simulation Pediatric research Pediatrics People and Places Pharmacovigilance Phenotypes Quality management Questionnaires Questions Side effects |
| title | Utilization of the Naranjo scale to evaluate adverse drug reactions at a free-standing children's hospital |
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