Comparison of alemtuzumab, anti-thymocyte globulin, and post-transplant cyclophosphamide for graft-versus-host disease and graft-versus-leukemia in murine models

Graft-versus-host disease is a major complication after allogeneic hematopoietic stem cell transplantation for hematological malignancies. Immunosuppressive drugs, such as anti-thymocyte globulin, alemtuzumab, and post-transplant cyclophosphamide, have been used to prevent graft-versus-host disease...

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Veröffentlicht in:	PloS one 2021-01, Vol.16 (1), p.e0245232
Hauptverfasser:	Mashima, Kiyomi, Oh, Iekuni, Fujiwara, Ken, Izawa, Junko, Takayama, Norihito, Nakano, Hirofumi, Kawasaki, Yasufumi, Minakata, Daisuke, Yamasaki, Ryoko, Morita, Kaoru, Ashizawa, Masahiro, Yamamoto, Chihiro, Hatano, Kaoru, Sato, Kazuya, Ohmine, Ken, Fujiwara, Shin-Ichiro, Ohno, Nobuhiko, Kanda, Yoshinobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alemtuzumab - therapeutic use Anatomy Animal models Animals Antibodies Antilymphocyte Serum - therapeutic use Antithymocyte globulin Biology Biology and life sciences Comparative analysis Computed tomography Cyclophosphamide Cyclophosphamide - therapeutic use Disease Models, Animal Drug therapy Editing Experiments Female Globulins Graft versus host disease Graft versus host reaction Graft vs Host Disease - drug therapy Graft vs Host Disease - etiology Graft vs Host Disease - prevention & control Grafting Hematology Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Histology Humans Immunosuppressive agents Immunotherapy Leukemia Luciferin Lymphocytes Lymphocytes T Lymphoma Medical imaging Medical research Medicine Medicine and Health Sciences Methodology Mice Mice, Inbred NOD Mice, SCID Monoclonal antibodies Research and Analysis Methods Severity of Illness Index Sodium salts Stem cell transplantation Stem cells Substrates Targeted cancer therapy Thymocytes Transplantation Transplants & implants Tumor Burden Viruses
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