CYP450 core involvement in multiple resistance strains of Aedes aegypti from French Guiana highlighted by proteomics, molecular and biochemical studies

Insecticide resistance is a worldwide threat for vector control around the world, and Aedes aegypti, the main vector of several arboviruses, is a particular concern. To better understand the mechanisms of resistance, four isofemale strains originally from French Guiana were isolated and analysed usi...

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Veröffentlicht in:	PloS one 2021-01, Vol.16 (1), p.e0243992
Hauptverfasser:	Epelboin, Yanouk, Wang, Lanjiao, Giai Gianetto, Quentin, Choumet, Valérie, Gaborit, Pascal, Issaly, Jean, Guidez, Amandine, Douché, Thibaut, Chaze, Thibault, Matondo, Mariette, Dusfour, Isabelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Aedes - drug effects Aedes - genetics Aedes - metabolism Aedes aegypti Animals Archives & records Bioassays Biochemistry, Molecular Biology Bioinformatics Biological research Biology Biology and Life Sciences Biology, Experimental Computer applications Cytochrome Cytochrome P-450 Cytochrome P-450 Enzyme System - genetics Cytochrome P450 Cytochromes P450 Data analysis Editing Enzymes Epidemics Esterases Esterases - metabolism Female French Guiana Gene Knockdown Techniques Genetic aspects Genotype Global health Health risks Inactivation, Metabolic - genetics Insect Proteins - antagonists & inhibitors Insect Proteins - genetics Insect Proteins - metabolism Insecticide resistance Insecticide Resistance - genetics Insecticides Insecticides - pharmacology Intestinal Mucosa - metabolism Life Sciences Mass spectrometry Mass spectroscopy Medicine and Health Sciences Metabolism Methodology Mosquitoes Mutation Nitriles - pharmacology Oligonucleotides - metabolism Pesticide resistance Physical Sciences Physiological aspects Polymorphism, Single Nucleotide Population Population control Proteome - analysis Proteomics Public health Pyrethrins - pharmacology Reviews Scientific imaging Spectroscopy Visualization Voltage-Gated Sodium Channels - chemistry Voltage-Gated Sodium Channels - genetics Voltage-Gated Sodium Channels - metabolism
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