Poria cocos polysaccharide induced Th1-type immune responses to ovalbumin in mice

In the present study, we evaluated adjuvant potential of Poria cocos polysaccharide (PCP) on the Th1-type immune responses of C57/BL6 mice against ovalbumin (OVA). We first determined the effect of PCP on maturation of murine bone marrow derived dendritic cells (BMDCs), PCP significantly upregulated...

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Veröffentlicht in:	PloS one 2021-01, Vol.16 (1), p.e0245207-e0245207
Hauptverfasser:	Dong, Xiaoxiao, Li, Boye, Yu, Boyang, Chen, Tian, Hu, Qin, Peng, Bo, Sheng, Wang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aluminum Animals Antibodies Antibody Formation - immunology Antigens Biological response modifiers Biology and life sciences Bone marrow Bone Marrow Cells - immunology CD4 antigen CD4 lymphocytes CD40 antigen CD69 antigen CD8 antigen CD8-Positive T-Lymphocytes - immunology CD80 antigen CD86 antigen Cell proliferation Composition Cytokines Cytokines - immunology Cytotoxicity Dendritic cells Dendritic Cells - immunology Endocytosis Enzyme-linked immunosorbent assay Experiments Female Flow cytometry Fungal Polysaccharides - chemistry Fungal Polysaccharides - immunology Globular proteins Health aspects Immune response Immune response (cell-mediated) Immune system Immunity, Cellular - drug effects Immunization Immunoglobulin G Immunoglobulin G - immunology Interleukin 12 Interleukin 2 Interleukin 6 Laboratory animals Lymphocytes Lymphocytes T Medical research Medicine and health sciences Mice Molecular weight Ovalbumin Ovalbumin - immunology Penicillin Peptides Pharmacology, Experimental Pinocytosis Polysaccharides Poria cocos Research and Analysis Methods Splenocytes Th1 Cells - immunology Vaccines Wolfiporia - chemistry Wood-decaying fungi γ-Interferon
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