Reduction of hyperoxic acute lung injury in mice by Formononetin

The antioxidant and anti-inflammatory features of Formononetin, an isoflavone constituent extracted from traditional Chinese medicine, have been reported. The present study investigated that whether Formononetin plays a benefit on hyperoxic ALI. C57BL/6 mice were exposed to hyperoxia for 72 h to pro...

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Veröffentlicht in:	PloS one 2021-01, Vol.16 (1), p.e0245050-e0245050
Hauptverfasser:	Chen, Yin, Wei, Dong, Zhao, Jin, Xu, Xiangnan, Chen, Jingyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - drug therapy Acute Lung Injury - etiology Acute respiratory distress syndrome Animals Antioxidants Bioengineering Biology and Life Sciences Biotechnology Care and treatment Cytokines Development and progression Diagnosis Disease Models, Animal Edema Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Enzymes Feature extraction Health aspects Heme Heme oxygenase (decyclizing) Heme Oxygenase-1 - metabolism Herbal medicine Hyperoxia Hyperoxia - complications Inflammation Injury prevention Isoflavones Isoflavones - administration & dosage Isoflavones - therapeutic use Kinases Laboratory animals Lung - drug effects Lung - metabolism Lungs Macrophages Medicine and Health Sciences Medicine, Chinese Membrane Proteins - metabolism Mice Microvasculature Moisture content NF-E2-Related Factor 2 - metabolism Oxygenase Phytoestrogens - administration & dosage Phytoestrogens - therapeutic use Polymerase chain reaction Pretreatment of water Proteins Research and Analysis Methods Testing Thoracic surgery Traditional Chinese medicine Water content
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