Successful direct-acting antiviral therapy improves circulating mucosal-associated invariant T cells in patients with chronic HCV infection

Mucosal-associated invariant T (MAIT) cells have been shown to contribute in the pathogenesis of various liver diseases, including chronic hepatitis C virus (HCV) infection. This study was aimed at investigating the frequency, phenotype, and function of circulating MAIT cells, as well as their alter...

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Veröffentlicht in:	PloS one 2020-12, Vol.15 (12), p.e0244112-e0244112
Hauptverfasser:	Khlaiphuengsin, Apichaya, Chuaypen, Natthaya, Sodsai, Pimpayao, Reantragoon, Rangsima, Han, Win Min, Avihingsanon, Anchalee, Tangkijvanich, Pisit
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult AIDS Antiretroviral drugs Antiviral agents Antiviral Agents - administration & dosage Antiviral drugs Benzofurans - administration & dosage Biochemistry Biology and life sciences Chronic infection Cirrhosis Cloning Collaboration Cytokines Development and progression Drug Combinations Drug therapy Female Fibrosis Flow cytometry Health aspects Hepacivirus - immunology Hepacivirus - metabolism Hepatitis Hepatitis C Hepatitis C, Chronic - blood Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - immunology Hepatocytes HIV Human immunodeficiency virus Humans Imidazoles - administration & dosage Immunology Infections Invariants Liver Liver cancer Liver cirrhosis Liver diseases Lymphocytes Lymphocytes T Magnetic resonance Male Medicine Medicine and health sciences Middle Aged Mucosa Mucosal-Associated Invariant T Cells - immunology Mucosal-Associated Invariant T Cells - metabolism Pathogenesis Patients Phenotypes Physiological aspects Quinoxalines - administration & dosage Research and Analysis Methods Restoration Statistical analysis Stiffness T cell receptors T cells Therapy Viral infections Viruses
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