Intense light as anticoagulant therapy in humans

Blood coagulation is central to myocardial ischemia and reperfusion (IR) injury. Studies on the light elicited circadian rhythm protein Period 2 (PER2) using whole body Per2-/- mice found deficient platelet function and reduced clotting which would be expected to protect from myocardial IR-injury. I...

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Veröffentlicht in:	PloS one 2020-12, Vol.15 (12), p.e0244792-e0244792
Hauptverfasser:	Oyama, Yoshimasa, Shuff, Sydney, Davizon-Castillo, Pavel, Clendenen, Nathan, Eckle, Tobias
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesiology Animal tissues Animals Anticoagulants Anticoagulants (Medicine) Biology and Life Sciences Blood coagulation Blood Coagulation - physiology Blood plasma Blood platelets Blood Platelets - metabolism Calcium-binding protein Circadian rhythm Circadian rhythms Clotting Coagulation Evaluation Human performance Human tissues Humans Injuries Ischemia Laboratory animals Light Light therapy Male Mammals Medicine and Health Sciences Mice Myocardial ischemia Myocardial Ischemia - blood Myocardial Ischemia - metabolism Myocardial Reperfusion Injury - blood Myocardial Reperfusion Injury - metabolism Period 2 protein Period Circadian Proteins - genetics Period Circadian Proteins - metabolism Phototherapy Plasma Platelet aggregation Platelet Aggregation - physiology Platelets Proteins Proteomics Reperfusion Research and Analysis Methods Troponin
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