Optically activated, customizable, excitable cells

Genetically encoded fluorescent biosensors are powerful tools for studying complex signaling in the nervous system, and now both Ca2+ and voltage sensors are available to study the signaling behavior of entire neural circuits. There is a pressing need for improved sensors, but improving them is chal...

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Veröffentlicht in:	PloS one 2020-12, Vol.15 (12), p.e0229051-e0229051
Hauptverfasser:	Thomas, Merrilee, Hughes, Thomas E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate cyclase Adenylyl Cyclases - metabolism Biology and Life Sciences Biosensing Techniques - methods Biosensors Calcium Calcium - metabolism Calcium channels (voltage-gated) Calcium ions Cell research Cellular signal transduction Connexin 43 Connexin 43 - metabolism Cyclic AMP Cyclic AMP - metabolism E coli Engineering and Technology Enzymes Fluorescence Genetic code HEK293 Cells Humans Ion channels Light Mutation Nervous system Neural circuitry Neural networks Neurosciences Physical Sciences Physiological aspects Potassium Potassium channels (inwardly-rectifying) Potassium channels (voltage-gated) Potassium Channels, Inwardly Rectifying - metabolism Sensors Signal Transduction - physiology Signaling Sodium channels (voltage-gated)
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